Posterior mediastinal paraganglioma

Case contributed by Dr Charlie Chia-Tsong Hsu

Patient Data

Age: 35 years
Gender: Female

Incidental finding of a well marginated mediastinal lesion beneath the left main bronchus. 

Further characterization with CT examination demonstratse a circumscribed mass lesion interposed between the left superior and inferior pulmonary veins. Posterosuperiorly abuts the left main bronchus.

Case Discussion

Surgical excision of the mediastinal tumor was performed. Gross pathological specimen show an encapsulated tan brown tissue. Microscopic analysis show an encapsulated lesion comprising of tumor cells in tight nests surrounded by fibrovasular stroma. The nuclei are mildly pleomorphic with granular chromatin. The cytoplasm is relatively abundant, granular and eosinophilic. No mitosis or area of necrosis. Immunohistochemistry show the tumor cells are reactive with chromogranin but not cytokeratin. S100 highlights sustentacular cells around the balls of cells. Overall features are consistent with paraganglioma.

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Case information

rID: 20295
Published: 10th Nov 2012
Last edited: 8th Feb 2016
System: Chest
Inclusion in quiz mode: Excluded

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