Primary CNS lymphoma

Case contributed by A.Prof Frank Gaillard



Patient Data

Age: 60 years
Gender: Male

A large left frontal mass with low T2 signal, vivid contrast enhancement and profound diffusion restriction (ADC ~500 x 10-6 cm2/s) is surrounded by vasogenic edema which extends across the corpus callosum, with small nodules of enhancement scattered within it. 

Features are characteristic of CNS lymphoma


Case Discussion

Patient went on to have surgery.


MICROSCOPIC DESCRIPTION: Paraffin sections show fragments of a densely hypercellular tumor. This is composed of atypical large lymphoid cells with round, oval and angulated nuclei with an open chromatin arrangement, conspicuous nucleoli and a narrow rim of pale cytoplasm.

These show strong membrane immunostaining for CD20, strong perinuclear staining for bcl-2 and strong nuclear staining for MUM-1 and PAX5. These are arranged in diffuse sheets and are admixed with small T lymphocytes (CD4+>CD8+). Frequent mitotic figures are identified.

Similar atypical cells are seen in perivascular spaces in adjacent white matter, extending through vessel walls. The features are of non Hodgkin's diffuse large B cell lymphoma.

FINAL DIAGNOSIS: non-Hodgkin's diffuse large B cell CNS lymphoma 


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Case information

rID: 44693
Published: 4th May 2016
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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