Primary CNS lymphoma

Case contributed by Assoc Prof Frank Gaillard

Single image from a non-contrast CT demonstrates a vague bilateral hyperdensity crossing the midline. 


Vividly enhancing mass extends across the corpus callosum. It demonstrates diffusion restriction and is centrally relatively low in T2 signal. 


Paraffin sections of the specimen show accumulation of large atypical mononuclear cells around small caliber vascular channels with invasion of the walls of some vessels noted. The atypical cells have large round, oval and angulated hyperchromatic and vesicular nuclei and a narrow rim of pale cytoplasm. An occasional mitotic figure is noted.

These atypical cells show strong surface immunostaining for the B lymphocyte markers, CD20 and CD79a. A moderate number of small mature CD3+ T lymphocytes are also present.


Non-Hodgkin large B cell CNS lymphoma.

Case Discussion

This case is fairly typical of CNS lymphoma which has a predilection from crossing the midline. 

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Case information

rID: 3975
Published: 6th Jul 2008
Last edited: 31st Dec 2019
Inclusion in quiz mode: Included

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