Progressive multifocal leukoencephalopathy
30 years old male with no clear history. LAB test show positive HIV.
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Multiple confluent areas of T2/Flair bright signal noted mainly involving bilateral frontoparietal and right temporal subcortical white matter with asymmetrical distribution, these areas show restriction. No enhancement was noted.
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system characterized by widespread lesions due to infection with JC virus. This type of demyelinating disease has strong association with immunosuppressed patient.
- FACR AGOMD. Osborns Brain. Lippincott Williams & Wilkins. ISBN:1931884218. Read it at Google Books - Find it at Amazon
- Küker W, Mader I, Nägele T et-al. Progressive multifocal leukoencephalopathy: value of diffusion-weighted and contrast-enhanced magnetic resonance imaging for diagnosis and treatment control. Eur. J. Neurol. 2006;13 (8): 819-26. doi:10.1111/j.1468-1331.2006.01362.x - Pubmed citation