Prostate metastases - widespread

Case contributed by Frank Gaillard
Diagnosis almost certain

Presentation

Very delirious and very watery constant bowel movements.

Patient Data

Age: 80 years
Gender: Male

Chest and abdominal x-rays

x-ray

Chest x-ray demonstrates very widespread pulmonary nodules. 

Abdominal x-ray reveals mixed destructive lytic and sclerotic pelvic changes on the left. 

CT abdomen and pelvis

ct

Multiple abnormalities are present.

There is a diffuse abnormality of the distal colon, sigmoid colon and rectum, characterized by bowel wall thickening and peri-colonic fat stranding.  This occurs in the region of presumed radiotherapy treatment and would be consistent, in this setting, with radiation colitis.  The more proximal large and small bowel loops are prominent suggesting a degree of functional obstruction.

Multiple liver lesions with low attenuation and ill-defined margins.  Similarly, multiple pulmonary lesions consistent with multiple metastases.  

Large retroperitoneal lipoma measuring approximately 11cm in diameter, with vessels seen to coarse through this region.  

The right adrenal gland is bulky with either an adenoma or a further metastasis. The pancreas and kidneys are normal with small cortical cysts seen within the kidneys but no evidence of hydronephrosis.  Bilateral fat-containing inguinal hernias, with multiple prominent lymph nodes demonstrated within the left inguinal region, the largest of which has a short-axis diameter of 1.5cm.  

Review of the bones demonstrates mixed sclerotic and lucent lesion involving most of the left hemipelvis consistent with malignant disease.  A further soft tissue deposit is demonstrated within the coccyx/distal sacrum measuring approximately 4.2 x 2.8cm. Subtle sclerosis in the L4 vertebral body extending into the posterior elements are suspicious for further metastatic disease.  An IDC is demonstrated within a contracted bladder which has some mild thickening and some hyperdensity in the dependent portions which may represent radiation cystitis and clinical correlation is recommended.

Case Discussion

This 80-year-old man with known metastatic prostate carcinoma was receiving radiotherapy to left hemipelvis.  

Diffuse bowel wall thickening involving the rectum, sigmoid colon and distal colon consistent with radiation colitis in the setting of radiation to the region.  There is prominence of the large bowel and small bowel loops which may reflect a degree of functional obstruction.  Skeletal lesions, liver lesions and multiple lung lesions are noted.  This is somewhat unusual for prostate cancer but can occur.  

An additional unusual finding is that of several small well-defined low-density nodules seen within the valvulae conniventes of small bowel loops that may represent metastases from the primary is considered, although this is very unusual and other non-malignant lesions such as small polyps can be considered. 

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