Protoplasmic astrocytoma

Case contributed by Dr Bruno Di Muzio

Presentation

Seizure.

Patient Data

Age: 49

CT Brain

Modality: CT

There is a bad-defined expansile lesion in the left frontal lobe with signs of cortical involvement and local vasogenic oedema. Further investigation with MRI is mandatory for a better characterisation of this finding. 

Ventricular system and cisternal spaces appear normal.

There is no shift of the midline structures.

MRI Brain

Modality: MRI

There is a left frontal lobe tumour characterised by focal cortical involvement in the inferior frontal gyrus associated with an extensive area of high T2 signal in the adjacent white matter which slightly and partially suppress on FLAIR , extending partially to the adjacent insula and middle frontal gyrus. No contrast enhancement is observed. Mild areas of restricted diffusion are observed within the tumour. 

Ventricular system and cisternal spaces appear normal. There is no shift of the midline structures. The visualized orbits, paranasal sinuses and calvarium appear unremarkable.

Case Discussion

This case represents a left frontal solid tumour involving the cortex and with features suggesting a low grade glioma. The tumour was resected and confirmed as a protoplasmic astrocytoma

Until recently, protoplasmic astrocytomas were classified as a subtype low-grade astrocytoma, however, in the latest (2016) update to WHO classification of CNS tumours, protoplasmic astrocytomas no longer exists as a distinct entity. 

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Case Information

rID: 38789
Case created: 4th Aug 2015
Last edited: 21st Jul 2016
Tag: rmh
Inclusion in quiz mode: Included

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