Pseudomembranous colitis - toxic megacolon

Case contributed by Chris O'Donnell
Diagnosis almost certain

Presentation

On oral antibiotics. Unwell with abominal pain, diarrhea and bleeding. Not getting better.

Patient Data

Age: 40 years
Gender: Female

Gross edema of the left hemicolonic wall with marked proximal colonic distension.  Note surrounding inflammation with signs of low serum albumin including marked subcutaneous edema on CT. There are multiple enlarged mesenteric lymph nodes. Patient is unwell with poor nutrition and colonic dilatation = toxic megacolon. Clostridium difficile cultured in feces.

1 wk prior

ct

One week prior had less marked edema of left hemicolonic wall, no proximal colonic dilatation, and no signs of poor nutrition including subcutaneous edema.

Case Discussion

Pseudomembranous colitis

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