Pulmonary Langerhans cell histiocytosis
Smoker with initial symptoms characterised by back pain. MRI has demonstrated the presence of an osteolytic area of a vertebral body.
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HRCT shows the presence of a couple of small cystic lesion in the anterior segment of the right upper lobe and the presence, above all in the right lobe, of small nodules.
Bone window shows the osteolytic lesion of the body of L1
Langerhans cell histiocytosis is a rare, multi-systemic pathology that can affect many organs, including bones and lungs and largely affecting females, with a higher prevalence in smokers.
In the present case, the symptomatology began at a skeletal level, but showing some pulmonary findings compatible with an early stage of pulmonary involvement.
The diagnosis was made with the biopsy of a spinal lesion, with histology confirming Langerhans cell histiocytosis
- 1, Stull MA, Kransdorf MJ, Devaney KO. Langerhans cell histiocytosis of bone. (1992) Radiographics : a review publication of the Radiological Society of North America, Inc. 12 (4): 801-23. doi:10.1148/radiographics.12.4.1636041 - Pubmed
- 2, Zaveri J, La Q, Yarmish G, Neuman J. More than just Langerhans cell histiocytosis: a radiologic review of histiocytic disorders. (2014) Radiographics : a review publication of the Radiological Society of North America, Inc. 34 (7): 2008-24. doi:10.1148/rg.347130132 - Pubmed