Radiation leukoencephalopathy

Case contributed by Dr Francis Fortin


Whole-brain prophylactic radiation therapy 5 years prior. Presents with gradual-onset impaired cognition.

Patient Data

Age: 50 years
Gender: Male

5 years prior, pre-treatment

Mild non-specific predominantly patchy white matter hyperintensities.


5 years after whole-brain radiation

5 years later, marked confluent subcortical T2/FLAIR hyperintensities have appeared. Note also hyperintensities surrounding the dentate nuclei. Cerebral and cerebellar atrophy has also significantly progressed. There are no significant microhemorrhages on gradient echo sequences. Note the typical sparing of U-fibers in radiation-induced leukoencephalopathy.

Case Discussion

Typical appearance with U-fiber sparing of radiation leukoencephalopathy.

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Case information

rID: 63074
Published: 12th Sep 2018
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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