Renal angiomyolipoma

Case contributed by Dr Andrew Ryan


Presents with 15 mm lower pole renal mass. Partial nephrectomy converted to total nephrectomy.

Patient Data

Age: 65 years
Gender: Female

Macroscopic appearance of angiomyolipoma with predominantly pale grey to white tumour - there is a vague area of 'yellowish' tumour in the left upper quadrant corresponding to an area of rich in adipose tissue.


Low power histology of angiomyolipoma showing sharp circumscription. This is a muscle rich variant (solid eosinophilic areas dominate) with only scattered adipose tissue (interspersed cleared areas).

Medium power histology of angiomyolipoma with mixed smooth muscle and adipose tissue. There is a cuff of normal renal parenchyma in the lower aspect of the picture.

High power of angiomyolipoma with scattered thick walled vessels (central) set within stroma composed of smooth muscle (eosinophilic cells) and adipose tissue (clear rounded spaces). 

Case Discussion

The textbook 'tri-phasic' appearance is not always present which can pose a diagnostic dilemma. As pathologists, we are seeing more core biopsies taken to try and identify the tumour type. On histology, the typical three components (vessels, smooth muscle and fat) are seen in variable proportions, but ‘monophasic’ (only one component) and ‘biphasic’ (two components) can be seen, especially if the tumour is only minimally sampled (e.g. core biopsy). Tumour cells are usually positive on immunohistochemistry for HMB45, CD117, CD63, and negative for cytokeratin and other epithelial markers.

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Case information

rID: 16061
Published: 13th Dec 2011
Last edited: 11th Apr 2018
System: Urogenital
Inclusion in quiz mode: Excluded

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