Renal angiomyolipoma: gross pathology and histology

Case contributed by Dr Andrew Ryan


Presents with 15 mm lower pole renal mass. Partial nephrectomy converted to total nephrectomy

Patient Data

Age: 63
Gender: Female

Macroscopic appearance of angiomyolipoma with predominantly pale grey to white tumour - there is a vague area of 'yellowish' tumour in the left upper quadrant corresponding to an area of rich in adipose tissue.

See individual images for findings. 

Case Discussion

The textbook 'tri-phasic' appearance is not always present which can pose a diagnostic dilemma. As a pathologists, we are seeing more core biopsies taken to try and identify the tumour type. On histology the typical three components (vessels, smooth muscle and fat) are seen in variable proportions, but ‘monophasic’ (only one component) and ‘biphasic’ (two components) can be seen, especially if the tumour is only minimally sampled (eg core biopsy). Tumour cells are usually positive on immunohistochemistry for HMB45, CD117, CD63, and negative for cytokeratin and other epithelial markers.

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Case information

rID: 16061
Case created: 13th Dec 2011
Last edited: 10th Sep 2016
System: Urogenital
Inclusion in quiz mode: Excluded

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