Renal cell carcinoma - papillary type

Case contributed by Jose Rodriguez Vazquez
Diagnosis certain

Presentation

Past medical history of end stage renal disease secondary to hypertension and status - post left lower quadrant kidney transplant presents for routine follow-up.

Patient Data

Age: 60 years
Gender: Male
ultrasound

Grey-scale and color doppler images of the native right kidney demonstrates a new 1.8 cm solid appearing exophytic mass arising from the posterior interpolar region. This did not demonstrate significant color doppler flow.

Subsequent MRI demonstrates a 1.8 cm exophytic mass arising from the posterior interpolar region of the right kid. The mass demonstrates decreased signal on T2WI and isointense signal on T1WI. On post contrast substraction images, the mass demonstrates minimal arterial phase hyperenhancemnt with progressive increased enhancement on delayed images. No fat or restricted diffusion was seen associated with the mass.

There are multiple bilateral simple and hemorrhagic renal cysts.

Case Discussion

Patient underwent right nephrectomy. Pathology revealed a papillary renal cell carcinoma.

Key points:

  • papillary RCC typically shows an expansile pattern of growth

  • papillary RCC tend to be hypoechoic on ultrasound

  • they typically show iso- to hypointense signal on T1-WI and hypointense signal T2-WI on MRI

  • on post contrast images, papillary RCC tend to enhance less than clear cell RCC, particularly on corticomedullary or renal cortical phase

  • second most common subtype of RCC

  • less aggressive than Clear Cell RCC

  • associated with hereditary papillary renal carcinoma, an autosomal dominant syndrome

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