Ring enhancing cerebral metastasis

Case contributed by A.Prof Frank Gaillard

Ring-enhancing mass in the left posterior frontal lobe with a small amount of surrounding vasogenic oedema. Some peripheral (but not central) diffusion restriction. 

Histopathology

Final Diagnosis: Left frontal brain tumour, resection: Metastatic carcinoma.

Microscopic Description:

Sections show brain parenchymal fragments heavily involved by metastatic tumour. The tumour cells form cohesive clusters and sheets of highly malignant cells with frequent mitoses and areas of necrosis. The tumour border is relatively well circumscribed. In the adjacent gliotic brain parenchyma, capillary-sized blood vessels appear markedly thickened with hyalinized walls and sometimes a perivascular lymphocytic infiltrate. Tumor cells are strongly immunoreactive for CK7. Immunohistochemistry for CK20, GCDFP, progesterone and estrogen receptors, CDX2 and TTF-1 is negative. This immunoprofile may still represent a primary from lungs and upper gastrointestinal tract.

Interestingly, the above mentioned thick capillaries are surrounded and infiltrated by many CD4+ cells and some CD8+ reactive T-cells. Also, HLA-DR expression is increased especially in microglia and endothelial cells. These changes are consistent with the patient's history of scleroderma.

Case Discussion

'Perfect' ring enhancing lesion which is not a cerebral abscess (lack of central diffusion restriction on DWI and relative paucity of oedema). MAGIC DR is a useful mnemonic for this appearance. 

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Case information

rID: 5563
Case created: 5th Feb 2009
Last edited: 21st Sep 2015
Inclusion in quiz mode: Included

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