Sarcoidosis - osseous involvement

Case contributed by Matt Skalski
Diagnosis almost certain


Hand pain.

Patient Data

Age: 40 years
Gender: Female

There is well-defined lytic destruction of the first proximal phalanx and 2nd metacarpal, with a preserved honeycomb trabecular pattern in these areas. These lesions extend throughout the entire length and diameter of the involved bones. The 2nd metacarpal is mildly expanded overall, with irregular areas of calcification along the ventral and radial aspect of the diaphysis likely representing callus formation from a healing pathological fracture. 

The exostotic area along the ulnar aspect of the 5th metacarpal is likely from previous fracture, given the anterior angulation at this site. Multiple traction enthesophytes are noted along the medial and lateral aspects of the phalanges (e.g. 4th proximal). 

Case Discussion

Path proven sarcoidosis

Osseous involvement with sarcoidosis is rare (~1-13%), however when it occurs it is common in the hands, and classically presents with a honeycomb/latticework trabecular pattern, as is seen in this case. Acroosteolysis with or without sclerosis may also be seen. 

Spina ventosa of tuberculosis and other granulomatous infections would be reasonable differential considerations in this case, however the findings seen here are quite characteristic for sarcoidosis. Other differential thoughts include the cyst-like foci seen in tuberous sclerosis, enchondromatosisfibrous dysplasia, musculoskeletal hemangiomatosis and hyperparathyroidism


Case images courtesy of Jamie Bedle, DC, DACBR. 

How to use cases

You can use Radiopaedia cases in a variety of ways to help you learn and teach.

Creating your own cases is easy.

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.