Sickle cell disease related osteosclerosis

Case contributed by Dr Aneta Kecler-Pietrzyk


30 years old referred by GP with ongoing cough.

Patient Data

Age: 30
Gender: Male

Diffusely sclerotic bones (osteosclerosis) incidentally seen on PA chest radiograph performed for suspected lower respiratory tract infection. Also, multilevel H-shaped vertebrae are seen. 

Case Discussion

Osteosclerosis or diffuse increased bones density is caused by many underlying diseases including:

  • congenital, e.g. osteopetrosis (usually associated with extensive nephrocalcinosis)
  • hematological, e.g. myelofibrosis, mastocytosis (dermatographia is very characteristic for this entity) and sickle cell anemia
  • metabolic, e.g. secondary hyperparathyroidism (renal osteodystrophy)
  • malignant, e.g. metastatic disease, most commonly from prostate or breast primary neoplasm
  • toxic, e.g. fluorosis, vitamin D hypervitaminemia

In this case, sickle cell anemia turned out to be a cause (H-shaped vertebrae helped to narrow the differential).

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Case information

rID: 52445
Published: 8th Apr 2017
Last edited: 12th Apr 2017
Inclusion in quiz mode: Included

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