Sinonasal undifferentiated carcinoma

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: Adult

Heterogeneously enhancing mass centered in ethmoidal region, eroding the surrounding bones, extending intracranially and into bilateral orbits.

Case Discussion

Histology comment:

I think it fits best with sinonasal undifferentiated carcinoma. The major alternative diagnosis would be small cell carcinoma, and I thought that the nuclear morphology, with many cells having prominent nucleoli and some have at least moderate amounts of cytoplasm, was very much against that diagnosis. The morphology and immunohistochemical staining pattern are entirely consistent with sinonasal undifferentiated carcinoma. I did not think the morphology was correct for lymphoepithelial carcinoma.

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Case information

rID: 4724
Published: 2nd Oct 2008
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

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