Sjögren syndrome

Case contributed by Assoc Prof Frank Gaillard

Case Discussion

Sjögren syndrome : presenting with bilateral lacrimal gland masses

Final diagnosis

Biopsy, left lacrimal gland.  Reactive lymphoid hyperplasia, consistent with Sjögren syndrome.

Microscopic description

The left lacrimal gland biopsy shows a heavy lymphoid infiltrate with destruction of the acini and preservation of ducts. The infiltrate is composed of large lymphoid follicles with prominent and irregularly shaped germinal centers surrounded by a small lymphocytic infiltrate. Immunoperoxidase stains show prominent B cell staining of the follicles with T cells in the interfollicular space. Staining for light chains shows equal numbers of kappa and lambda light chains. The histologic changes are most consistent with the inflammatory infiltrate seen in Sjögren syndrome.

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Case information

rID: 9153
Published: 20th Mar 2010
Last edited: 14th Feb 2021
System: Head & Neck
Inclusion in quiz mode: Included

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