Sjögren syndrome

Case contributed by A.Prof Frank Gaillard
Modality: CT

Case Discussion

Sjögren syndrome : presenting with bilateral lacrimal gland masses

Final diagnosis

Biopsy, left lacrimal gland.  Reactive lymphoid hyperplasia, consistent with Sjögren syndrome.

Microscopic description

The left lacrimal gland biopsy shows a heavy lymphoid infiltrate with destruction of the acini and preservation of ducts. The infiltrate is composed of large lymphoid follicles with prominent and irregularly shaped germinal centers surrounded by a small lymphocytic infiltrate. Immunoperoxidase stains show prominent B cell staining of the follicles with T cells in the interfollicular space. Staining for light chains shows equal numbers of kappa and lambda light chains. The histologic changes are most consistent with the inflammatory infiltrate seen in Sjögren syndrome.

PlayAdd to Share

Case Information

rID: 9153
Case created: 20th Mar 2010
Last edited: 24th Nov 2015
System: Head & Neck
Inclusion in quiz mode: Included

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.