Solitary fibrous tumour of brain

Case contributed by Dr Andrew Lawson

Presentation

Headache.

Patient Data

Age: 50
Gender: Female

Hyperdense lesion on non contrast scan. See MR report.

T2 hypointense T1 isointense vividly enhancing mass applied to the floor of the anterior cranial fossa left of midline has dimensions of 3.4 x 3.6 x 4.6 cm. There is extensive vasogenic oedema through the left frontal lobe and into the genu of the corpus callosum. The anterior aspect of the falx is deviated toward the right, with 12 mm subfalcine herniation. No uncal herniation. No evidence of extension of tumour into orbit, ethmoid or nasal cavity. No further intracranial mass or site of pathological contrast enhancement. A few tiny T2 hyperintense white matter foci are compatible with patient age. No hydrocephalus.

See pathology report below.

Case Discussion

The sections show a moderately cellular tumour. The tumour forms fascicles and bundles, intermixed with collagenous tissue in the background. No whorls are seen. The tumour cells have ovoid nuclei with no nuclear pleomorphism. Occasional mitoses are noted (less than 4 per 10 high power fields). Scattered staghorn type blood vessels are present. There is one area of brain invasion, with tumour infiltrating into the neuropil. 

DIAGNOSIS: Brain tumour: Solitary fibrous tumour.

Comment: No grading has been given in the WHO classification. Most behave in a benign fashion. However, there is brain invasion in this biopsy and its significance is unclear. No other adverse histological features are otherwise seen.

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Case information

rID: 26982
Case created: 17th Jan 2014
Last edited: 9th Mar 2016
Inclusion in quiz mode: Included

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