Solitary fibrous tumor of the spinal cord

Case contributed by Assoc Prof Frank Gaillard


Presented with lower limb weakness. Had a non-diagnostic biopsy (sample too small) months earlier. Now progressive symptoms.

Patient Data

Age: 70 years
Gender: Female

Previous T1 to T4 laminectomy. A mass lesion measuring approximately 2 2 x 0.7 x 0.5 centimeters lies at the posterior and right side of the cord at the T2/T3 level. It is associated with expansion of the cord and extensive edema that extends from the C7 level down to the inferior limits of the scan.

The sagittal images suggests an intra-medullary location. The axial images suggest an exophytic component posteriorly. The mass is iso-intense to hypointense to cord on T1 and markedly hypointense on T2 weighted images. The hypointense component is associated with a marked contrast enhancement.  No other areas of abnormal contrast enhancement are seen. 

Annotated image

The tumor (blue arrows) is of low signal on T2 and T1 sequences and demonstrates vivid contrast enhancement. It is associated with rostral and caudal edema (yellow arrows). Previous laminectomy (red arrows) is visible. 


MACROSCOPIC DESCRIPTION: Spinal cord tumour: A piece of rubbery pink to fawn tissue  20x5x6mm. 

MICROSCOPIC DESCRIPTION: The sections show a well-demarcated tumour with hyper and  hypocellular areas.  In the cellular areas, the tumour forms short  fascicles. The tumour cells have elongated nuclei, hyperchromasia and  scanty ill-defined cytoplasm. 1 mitosis per 10 high power fields is  seen. Some staghorn type blood vessels are present in the background, which is focally fibrosed, containing keloidal-type collagen bundles.   No necrosis is identified. The tumour cells are CD34 and CD99  positive. Factor XIIIa is focally and weakly positive. They are EMA,  AE1/3, S-100 and Melan-A negative. The Ki-67 index is about 4%. The  features are in keeping with a solitary fibrous tumour.   

FINAL DIAGNOSIS:  Spinal cord tumour: Solitary fibrous tumour of the spinal cord.

Case Discussion

Though most solitary fibrous tumors are benign, some may  behave aggressively and long term follow-up is mandatory. There are no  features of malignancy in this biopsy (namely moderate to marked  cytological atypia, tumor necrosis, more than 4 mitoses per 10HPFs,  infiltrative margins).  

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Case information

rID: 19563
Published: 24th Sep 2012
Last edited: 14th Aug 2019
Tag: spine
Inclusion in quiz mode: Included

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