Presentation
Previous Thorotrast contrast administration.
Abdominal radiograph shows multiple micronodular hyperdense lesions speckled in the left hypochondrium.
Select illustrative CT non-contrast axial slice
Select illustrative axial slice demonstrates multiple micronodular hyperdense lesions in the spleen.
Case Discussion
In this patient with previous known administration of Thorotrast contrast, findings are in-keeping with splenic accumulation (or thorotrastosis).
Thorotrast is a suspension of radioactive thorium dioxide that was used as a contrast agent until the 1950s. Following administration, it typically accumulates within the body - particularly the liver, spleen, and peripancreatic lymph nodes. Radiographically, it is seen as metallic densities which may have a multinodular, miliary or diffuse pattern of distribution. Due to Thorotrast being an alpha emitter with a very long half-life, it is highly carcinogenic, and thus is no longer in use.
Case uploaded on behalf of and courtesy of Dr Paul McCoubrie.