IMPORTANT: We currently have a number of bugs related to image cropping and are actively trying to resolve them. In the meantime, we have disabled cropping. Apologies for any inconvenience. Stay informed: radiopaedia.org/chat

Sporadic Creutzfeldt-Jakob disease

Case contributed by Prashant Gupta
Diagnosis certain

Presentation

Acute onset confusion, no infective symptoms, no weakness.

Patient Data

Age: 60 years
Gender: Female

Axial T2 and DWI show restricted diffusion in the left caudate nucleus and left cerebral cortex.

Case Discussion

The lack of white matter involvement goes against ischemic stroke, which was not the clinical presentation either. Encephalitis is another differential but clinically the patient had only confusion of acute onset.

The patient had positive CSF RT-QUIC test, which is 100% specific for Creutzfeldt-Jakob disease, and the patient had also had a high 14-3-3 protein result.

How to use cases

You can use Radiopaedia cases in a variety of ways to help you learn and teach.

Creating your own cases is easy.

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.