Takayasu's arteritis (pulseless disease)
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CTA of a patient with Takayasu arteritis
Granulomatous inflammatory vasculitis affects walls of medium and large vessels. Marked intimal proliferation and fibrosis lead to occlusion and narrowing of aorta and involved arteries; aneurysms may also be found.
Age: 90% < 30 years (in contradistinction to all other arteritis).
More common in females. M:F 1:8
- type 1: aortic arch
- type 2: abdominal aorta
- type 3: entire aorta
- type 4: pulmonary arteries
- stenoses of arch vessels (most common)
- stenosis and occlusion of aorta (may mimic coarctation)
- thickening of aortic wall
- pulmonary artery involvement, 50%
- abdominal aorta coarctation and renal artery stenoses
- Eva Castañer, MD. When to Suspect Pulmonary Vasculitis: Radiologic and Clinical Clues. RadioGraphics 2010; 30:33–53.