Testicular mixed germ cell tumor

Case contributed by Ammar Ashraf
Diagnosis certain

Presentation

Right testicular pain for a few weeks, getting worse over the last three days. No urinary symptoms.

Patient Data

Age: 25 years
Gender: Male
ultrasound
Longitudinal
and transverse
Longitudinal
Longitudinal
Transverse
Transverse
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Info

Large heterogeneous mass measuring approximately 6 x 6 x 10 cm, almost completely replacing the right testis. Color and pulsed Doppler ultrasound examinations show increased vascularity within the mass.

This study is a stack
Axial
non-contrast
This study is a stack
Axial C+
arterial phase
This study is a stack
Axial C+ portal
venous phase
This study is a stack
Coronal
non-contrast
This study is a stack
Coronal C+
arterial phase
This study is a stack
Coronal C+ portal
venous phase
This study is a stack
Sagittal
non-contrast
This study is a stack
Sagittal C+
arterial phase
This study is a stack
Sagittal C+ portal
venous phase
Reformatted
Oblique MIP image
Reformatted
Oblique MIP image
This study is a stack
Reformatted
VR images
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Info

Large right testicular mass being supplied by an artery arising from the anterior aorta at L3 level between the renal and inferior mesenteric arteries (right testicular artery). It shows heterogeneous enhancement along with multiple non-enhancing cystic/necrotic areas. No abdominopelvic lymphadenopathy or distant metastasis are seen.

Photograph
Histopathology
report
Histopathology
report
Immunohist
ochemistry
Gross
pathology
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Info

Histopathology showed mixed germ cell tumor (teratoma 50%, seminoma 45% and embryonal cell carcinoma 5%). 

Case Discussion

A large heterogeneous right testicular mass was thought to likely represent a non-seminomatous germ cell tumor based on imaging findings, which was later proven to be a mixed germ cell tumor.

Laboratory investigations showed elevated tumor markers {AFP= 107 ng/ml (normal: ~8),  quantitative beta-HCG =29.4 IU/L (normal in males: <5) and LDH=334 U/L (normal: 125-220)}. 

The staging workup showed no evidence of distant metastasis. The patient underwent an uneventful radical right inguinal orchiectomy.

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