Tuberose sclerosis complex

Case contributed by Liz Silverstone



Patient Data

Age: 20 years
Gender: Male
  • scattered random micronodules

  • two myocardial fatty foci

  • numerous renal angiomyolipomas

  • no lung cysts

Coronal MIPs demonstrate micronodules well.

MinIPs are sensitive for cystic lung disease.

Case Discussion

Multifocal multinodular pneumocyte hyperplasia, myocardial fatty foci and numerous renal angiomyolipomas (AML) are typical features of tuberous sclerosis complex (TSC). Myocardial fatty foci occur in about 2/3 of tuberous sclerosis patients and are rare in the general population.

Subependymal giant cell astrocytoma (SEGA) is a life-threatening manifestation of tuberous sclerosis complex and brain MRI or CT is advised.

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