Tuberose sclerosis complex
Citation, DOI, disclosures and case data
At the time the case was submitted for publication Liz Silverstone had no financial relationships to ineligible companies to disclose.View Liz Silverstone's current disclosures
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scattered random micronodules
two myocardial fatty foci
numerous renal angiomyolipomas
no lung cysts
Coronal MIPs demonstrate micronodules well.
MinIPs are sensitive for cystic lung disease.
Multifocal multinodular pneumocyte hyperplasia, myocardial fatty foci and numerous renal angiomyolipomas (AML) are typical features of tuberous sclerosis complex (TSC). Myocardial fatty foci occur in about 2/3 of tuberous sclerosis patients and are rare in the general population.
Subependymal giant cell astrocytoma (SEGA) is a life-threatening manifestation of tuberous sclerosis complex and brain MRI or CT is advised.
- 1. Tresoldi S, Munari A, Di Leo G et al. Myocardial Fatty Foci in Adult Patients with Tuberous Sclerosis Complex: Association with Gene Mutation and Multiorgan Involvement. Radiology. 2015;277(2):398-405. doi:10.1148/radiol.2015141890 - Pubmed