Tuberous sclerosis

Case contributed by Dr Mohammad A. ElBeialy

Presentation

10 months old male baby with skin lesions and mild seizures.

Patient Data

Age: 10 months
Gender: Male
Modality: MRI
  • multiple bilateral periventricular and subependymal nodular lesions with predominantly high T1 and low to intermediate T2 / FLAIR signal intensity.
  • bilateral subcortical patchy areas of variable T1 and high T2 / FLAIR signal intensity with no restricted diffusion. Some subcortical lesions are possibly calcified with low T2 signal.
  • streaky linear T2 / Flair hyperintensities (radial bands) along the radial migrations from ventricle to cortex. These bands are oriented perpendicular to the ventricular wall.
  • focal deep white matter cyst–like T2 hyperintense lesions (cystoid degenerations) are seen; most evident at the right high posterior frontal lobe. 

 

Case Discussion

This case shows typical MRI findings of tuberous sclerosis of the brain with sucortical tubers and subependymal nodules (SEN). Tuberous sclerosis is one of the phakomatoses which are a group of neuroectodermal disorders characterized by coexisting skin lesons and CNS tumors. The typical classic triad of TS is mental retardation, adenoma sebaceoum and seizures, yet it is found in a minority of patients.   

PlayAdd to Share

Case Information

rID: 26372
Case created: 17th Dec 2013
Last edited: 16th Dec 2015
Inclusion in quiz mode: Included

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.