Tuberous sclerosis

Case contributed by Dr Hani Salam



Patient Data

Age: <10 years old
Gender: Female

CT brain

Multiple calcified subependymal nodules are noted along the margins of the lateral ventricles. 


MRI Brain

MRI demonstrates extensive T2 / FLAIR cortical and subcortical white matter regions of hyperintensity along with nodularity of the ventricular margins, which demonstrate signal drop out (best seen on gradient echo images) in keeping with calcification seen on CT. 


Ultrasound kidneys

Ultrasound of the left kidney demonstrates an 8 mm region of hyperechogenicity within the renal parenchyma, consistent with an angiomyolipoma. 

Case Discussion

This case demonstrates typical features of tuberous sclerosis, and the diagnosis can be made with a high degree of certainty merely on imaging features. An understanding of associated lesions (e.g. angiomyolipomas) allows for patients to be screened, once the diagnosis is made. 

PlayAdd to Share

Case information

rID: 10286
Published: 31st Jul 2010
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.