Tumefactive demyelination

Case contributed by Dr Ayaz Hidayatov


A young female came with a history of blurred vision, recurrent muscle weakness episodes on a right hand and foot and focal seizures since 2 weeks. No past medical history.

Patient Data

Age: 20 years
Gender: Female

MRI demonstrates two “tumor-like” oval lesions in the left frontoparietal region with extension to centrum semiovale. The lesions are peripherally hypointense and centrally hyperintense on T2WI, show suppression with mild hypointensity on FLAIR and hypointense on T1WI. The margins of lesions show peripherally restricted diffusion on DW images and after contrast administration shows incomplete or open ring enhancement. There is perilesional edema with mass effect and mild shift midline structures.


1 month post-treatment MRI

The post-treatment with high dose IV corticosteroids MRI performed after a month.

Post-treatment MRI shows decreasing lesions size, without enhancement of lesions and decrease in the volume of perilesional edema.

There was marked clinical improvement after high dose IV corticosteroids.

Findings suggestive with tumefactive demyelination.

Case Discussion

Tumefactive demyelinating lesions are an aggressive form of demyelination. There are focal zones of demyelination in the central nervous system and they often mimic a neoplasm.

Most patients with tumefactive demyelinating lesions do respond to steroid therapy.

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Case information

rID: 53951
Published: 15th Jun 2017
Last edited: 5th Feb 2020
Inclusion in quiz mode: Included

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