Tumefactive demyelination

Case contributed by Frank Gaillard


Left sided weakness

Patient Data

Age: 55 years
Gender: Male

MRI from another institution demonstrates a large rounded area of edema with incomplete rim enhancement in the right frontal lobe has appearances most in keeping with tumefactive demyelination. A few other white matter lesions are also present. 

Because the intial scan was reported as likely representing a glioma, the mass was biopsied. Histological examination confirmed the diagnosis of tumefactive demyelination

MRI 13 years later


MRI 13 years later shows typical changes of multiple sclerosis with multiple white matter plaques. The area of the previous biopsy and tumefactive demyelination is a gliotic cavity. 

Case Discussion

The patient remains well, although they have ongoing multiple sclerosis

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