Ultrasound-enhanced thrombolysis: EKOS endowave infusion catheter system

Case contributed by Jayanth Keshavamurthy , 10 Jun 2016
Diagnosis not applicable
Changed by Henry Knipe, 14 Jun 2016

Updates to Case Attributes

Diagnostic Certainty was set to .
Presentation was changed:
History of cervical cancer and chest pain. Evidence of acute DVT on ultrasound of legs. Echocardiogram showed pulmonary embolusembolism in PA. No CTA chest, Patient went for direct catheter directed thrombolysis.
Body was changed:
  • The EKOS catheters have ultrasound transducers within the wire of the catheter which uses ultrasound waves to accelerate the fibrinolytic process and therefore decrease treatment time and decrease the total dose of thrombolytic agent needed which should translate into decreased morbidity and mortality1.(1)

  • A prospective multicenter study with 150 patients with acute massive or submassive pulmonary emboliembolism who underwent ultrasound-facilitated, catheter directed, low-dose fibrinolysis showed decreased right ventricular dilatation, decreased pulmonary hypertension, reduced clot burden, and decreased intracranial hemorrhages in these patients. Efficacy outcomes were measured within 48 hours of initiation of fibrinolytic therapy 4.(4) In In the case presented, there was also improved cardiac function after administration of tPA via EKOS catheters within 48 hours. Therefore, this case supports the benefits of using EKOS catheters for the administration of fibrinolytics in pulmonary embolism. 
  • -<ul>
  • -<li>The EKOS catheters have ultrasound transducers within the wire of the catheter which uses ultrasound waves to accelerate the fibrinolytic process and therefore decrease treatment time and decrease the total dose of thrombolytic agent needed which should translate into decreased morbidity and mortality.(1)</li>
  • -<li>A prospective multicenter study with 150 patients with acute massive or submassive pulmonary emboli who underwent ultrasound-facilitated, catheter directed, low-dose fibrinolysis showed decreased right ventricular dilatation, decreased pulmonary hypertension, reduced clot burden, and decreased intracranial hemorrhages in these patients. Efficacy outcomes were measured within 48 hours of initiation of fibrinolytic therapy .(4) In the case presented, there was also improved cardiac function after administration of tPA via EKOS catheters within 48 hours. Therefore, this case supports the benefits of using EKOS catheters for the administration of fibrinolytics in pulmonary embolism. </li>
  • -</ul>
  • +<p>The EKOS catheters have ultrasound transducers within the wire of the catheter which uses ultrasound waves to accelerate the fibrinolytic process and therefore decrease treatment time and decrease the total dose of thrombolytic agent needed which should translate into decreased morbidity and mortality <sup>1</sup>.</p><p>A prospective multicenter study with 150 patients with acute massive or submassive pulmonary embolism who underwent ultrasound-facilitated, catheter directed, low-dose fibrinolysis showed decreased right ventricular dilatation, decreased pulmonary hypertension, reduced clot burden, and decreased intracranial hemorrhages in these patients. Efficacy outcomes were measured within 48 hours of initiation of fibrinolytic therapy <sup>4</sup>. In the case presented, there was also improved cardiac function after administration of tPA via EKOS catheters within 48 hours. Therefore, this case supports the benefits of using EKOS catheters for the administration of fibrinolytics in pulmonary embolism. </p>

Updates to Study Attributes

Caption was removed:
Name the catheters.
Findings was changed:
  1. Right IJ porta catheter.
  2. Left PICC line catheter.
  3. Right PICC approach EKOS catheter.

Patient had a Pulmonary Emboluspulmonary embolus and underwent catheter directed thrombolysis.

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