Wallerian degeneration

Case contributed by Dr Dalia Ibrahim

Presentation

History of old stroke

Patient Data

Age: 60 year old
Gender: Male
MRI

Large infarct in a left middle cerebral artery distribution,

A contiguous tract of gliosis (high signal at FLAIR WI)  leading from the region of cortical & subcortical neuronal injury towards the deep cerebral structures, along the expected topographical course of the involved white matter tract.

MRA revealed occluded left middle cerebral artery.

Annotated image

A contiguous tract of gliosis leading from an region of cortical or subcortical of neuronal injury towards the deep cerebral structures, along the expected topographical course of the involved white matter tract. (Arrows)

Case Discussion

Wallerian degeneration (WaD) is the process of antegrade degeneration of the axons and their accompanying myelin sheaths following proximal axonal or neuronal cell body lesions. It may result following neuronal loss due to cerebral infarction, trauma, necrosis, focal demyelination or haemorrhage.

It is seen as a contiguous tract of gliosis leading from an region of cortical or subcortical of neuronal injury towards the deep cerebral structures, along the expected topographical course of the involved white matter tract.

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Case information

rID: 29124
Case created: 5th May 2014
Last edited: 14th Mar 2016
Inclusion in quiz mode: Included

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