Wallerian degeneration in multiple sclerosis

Case contributed by Dr Heba Abdelmonem


A known case of neglected multiple sclerosis with deteriorating motor symptoms.

Patient Data

Age: 35 years
Gender: Female

MRI of the brain demonstrates typical appearance of Multiple sclerosis including Dawson fingers and multiple abnormal foci of altered signal involving the corpus callosum. Abnormally small size of the left cerebral peduncle with no signal changes. Preserved volume of the right cerebral peduncle with abnormal high T2 signal changes.

Case Discussion

A case with multiple sclerosis complicated with Wallerian degeneration of both cerebral peduncles (stage 4 on the left and stage 3 on the right). White matter demyelination alone may not be the only cause of progressive disability tin patient with MS, Wallerain degeneration of the ipsilateral corticospinal tract may be a major contributor in this disability as illustrated in our case.

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Case information

rID: 63190
Published: 18th Sep 2018
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included
Institution: Zagazig University Hospital

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