Well-differentiated liposarcoma: thigh

Case contributed by Dr Domenico Nicoletti


Swelling of the posterior distal left thigh for six months

Patient Data

Age: 70 years
Gender: Male

MRI left thigh including post-contrast images. 

In the posterior compartment of the left thigh, there is a well circumscribed mass with a main adipose component with a central irregularly solid component. It displays contrast enhancement.

The neurovascular bundle and the bone are not infiltrated.

Surgical excision was performed.



MRI following resection of the mass

MRI performed after removal of the lesion:

No definite evidence of enhancing mass can be seen in the surgical bed. 



Case Discussion

The well-differentiated liposarcoma (WDLS) is the most common type of liposarcoma. WDLS present as a painless, slowly growing tumour, usually in the retroperitoneum or limbs. It consists of proliferation of mature adipocytes.

WDLS usually present between 50 and 60 years of age, with a male predilection. It manifests as a slow growing, painless mass, often in the retroperitoneum or the limbs and rarely in the spermatic cord and in the mediastinum.

The mass is usually solid. They may cause symptoms of urinary or bowel obstruction, if the lesion compresses adjacent organs.

The prognosis of WDLS depends on tumour location. WDLS arising from extremities usually has a good prognosis after removal of the tumour, with a low risk of recurrence and low mortality.

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Case information

rID: 45044
Published: 12th May 2016
Last edited: 18th Apr 2017
Inclusion in quiz mode: Included

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