The well-differentiated liposarcoma (WDLS) is the most common type of liposarcoma. WDLS present as a painless, slowly growing tumour, usually in the retroperitoneum or limbs. It consists of proliferation of mature adipocytes.
WDLS usually present between 50 and 60 years of age, with a male predilection. It manifests as a slow growing, painless mass, often in the retroperitoneum or the limbs and rarely in the spermatic cord and in the mediastinum.
The mass is usually solid. They may cause symptoms of urinary or bowel obstruction, if the lesion compresses adjacent organs.
The prognosis of WDLS depends on tumour location. WDLS arising from extremities usually has a good prognosis after removal of the tumour, with a low risk of recurrence and low mortality.