Xanthogranulomatous cholecystitis

Case contributed by Nikolaos Gkouliaveras
Diagnosis almost certain

Presentation

One month of right upper quadrant abdominal pain.

Patient Data

Age: 40 years
Gender: Male

PA erect

x-ray
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Erect abdominal x-ray shows two large peripheral calcified structures projected onto the L1 vertebra, that probably represent gallstones.

ultrasound
Transverse
Transverse
Transverse
Transverse
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The gallbladder is non-distended, contains at least two large gallstones, and shows severe wall thickening. Impression of blurred boundaries of the gallbladder.

No dilation of the intrahepatic or common bile duct.

This study is a stack
Axial
non-contrast
This study is a stack
Axial C+ portal
venous phase
This study is a stack
Coronal C+ portal
venous phase
This study is a stack
Sagittal C+ portal
venous phase
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Thickening of the wall of the gallbladder and multiple large gallstones within it.

Intramural hypo-attenuating regions of varying sizes communicate with the gallbladder lumen.

Pericholecystic fluid collection.

Case Discussion

Xanthogranulomatous cholecystitis is a rare inflammatory disease that makes it difficult to distinguish between benign and malignant conditions

A focal, diffuse chronic inflammatory process is caused by the dilation of hypo-enhancing spaces in the wall of the gallbladder due to the rise of the intraluminal pressure caused by an impacted stone in the neck, leading to rupture of the Rokitansky-Aschoff sinuses into the wall. 

The patient went on to open surgical cholecystectomy, where macroscopically characteristic xanthogranulomatous cholecystitis emerged.

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