Zebra sign: pamidronate therapy
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The distance between the lines at the distal end of the leg is less than that at the proximal end. This is a reflection of the greater growth occurring around the knee; as the doses of pamidronate are given regularly, more growth has occurred between doses at the knee than at the ankle.
- Al Muderis, M., Azzopardi, T., Cundy, P. "Zebra Lines of Pamidronate Therapy in Children" J Bone Joint Surg Am 2007 89: 1511-1516