Articles

Articles are a collaborative effort to provide a single canonical page on all topics relevant to the practice of radiology. As such, articles are written and edited by countless contributing members over a period of time. A global group of dedicated editors oversee accuracy, consulting with expert advisers, and constantly reviewing additions.

2,302 results found
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Venous vascular malformation of the facial nerve

Venous vascular malformations of the facial nerve, previously known as facial nerve hemangiomas, are rare benign vascular malformations of the facial nerve usually presenting as a facial nerve palsy, which can be rapid onset mimicking a Bell palsy.  Terminology As they do not appear to have cl...
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Ventral cord herniation

Ventral cord herniation, also known by a variety of other terms such as spontaneous thoracic cord herniation or idiopathic spinal cord herniation, is a rare cause of focal myelopathy due to herniation of the thoracic cord through a dural defect.  Post surgical cord herniation can occur at any l...
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Ventral cord syndrome

Ventral cord syndrome (also known as anterior cord syndrome) is one of the incomplete cord syndromes and affects the anterior parts of the cord resulting in a pattern of neurological dysfunction dominated by motor paralysis and loss of pain, temperature and autonomic function. Anterior spinal ar...
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Ventral horn

The ventral horn of the spinal cord is one of the grey longitudinal columns found within the spinal cord. It contains the cell bodies of the lower motor neurones which have axons leaving via the ventral spinal roots on their way to innervate muscle fibers. Gross anatomy On transverse section o...
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Ventricular system

The ventricular system in the brain is composed of CSF-filled ventricles and their connecting foraminae. CSF is produced by ependymal cells which line the ventricles. They are continuous with the central canal. Ventricles contain around 1/5 of normal adult CSF volume, which is around 20-25 ml. ...
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Ventriculitis

Ventriculitis refers to inflammation, usually due to infection, of the ependymal lining of the cerebral ventricles. It is most often due to intraventricular rupture of brain abscess. Epidemiology Its epidemiology is varied and depends on the underlying cause.  meningitis (both pyogenic and vi...
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Ventriculoatrial shunt

Ventriculoatrial shunting is an alternative option for the diversion of CSF and relief of hydrocephalus. In this technique, the distal catheter is placed in the right atrium or even in the superior vena cava 1,2.  It is not the only alternative for the traditional ventriculoperitoneal shunt, an...
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Ventriculogallbladder shunt

Ventriculogallbladder shunts are a rare form of cerebrospinal fluid diversion, used when a ventriculoperitoneal shunt is not possible (e.g. intra-abdominal adhesions, peritonitis). Differential diagnosis a ventriculoperitoneal shunt in a right upper quadrant CSFoma See also ventriculoperiton...
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Ventriculomegaly

Ventriculomegaly is defined as enlargement of the ventricles. Simply, there are two causes: hydrocephalus communicating non-communicating parenchymal atrophy Refer to the article on hydrocephalus vs atrophy for more details on how to differentiate both entities. 
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Ventriculoperitoneal shunt

Ventriculoperitoneal (VP) shunts are a device used to shunt cerebrospinal fluid in the treatment of hydrocephalus. As the name suggests, a catheter is placed with its tip in the ventricle. The external portion of the catheter is connected to a valve that regulates the flow of CSF based on a pre...
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Ventriculopleural shunt

Ventriculopleural shunting is an alternative option for the diversion of CSF and relief of hydrocephalus. In this technique, the distal catheter is placed in the pleural space. It is an alternative to a ventriculoperitoneal shunt (often considered a next most used alternative). Complications s...
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Ventriculus terminalis

The ventriculus terminalis or terminal ventricle of Krause, also known as the 5th ventricle, is an ependymal-lined fusiform dilatation of the terminal central canal of the spinal cord, positioned at the transition from the tip of the conus medullaris to the origin of the filum terminale.  It re...
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Venus necklace

A Venus necklace is a term almost never used, but for the sake of completeness is included here. It is used by some authors 1 to describe a series of T2 hyperintense lesions on the inferior surface of the corpus callosum in the midline (callososeptal interface), most frequently seen in multiple ...
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Vermian lobulation

Evaluation of vermian lobulation is essential in assessment of the vermian maturity. MRI is a useful tool in assessment of the fetal posterior fossa. Normal Vermian lobulation by weeks 1: By 21 weeks - Prepyramidal fissure can be seen between the tuber and pyramis. 21 to 22 weeks - Preculmina...
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Vermian maturity assessment (approach)

Radiological evaluation of the posterior fossa is an essential part of the routine fetal assessment, including vermian maturity assessment. Radiographic features Ultrasonography is a readily available diagnostic tool in the assessment of the fetal posterior fossa but is sometimes limited due t...
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Vermis

Gross anatomy The vermis (pl: vermes) of the cerebellum is an unpaired medial structure which separates the cerebellar hemispheres. The neocerebellar posterior lobes join in the midline behind the primary fissure to separate the vermis into superior and inferior portions. The vermis can be furt...
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Verocay bodies

Verocay bodies are a histological feature of schwannomas and represent a particular growth pattern of Antoni type A pattern in which tumor cells form alternating parallel rows of nuclear palisades separated by regions of acellularity 1. 
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Vertebral artery dissection

Vertebral artery dissection, like arterial dissection elsewhere, is a result of blood entering the media through a tear in the intima. It is potentially lethal and can be difficult to diagnose clinically and radiologically. Epidemiology Vertebral artery dissections have an incidence of 1-5 per...
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Vertebral artery thrombosis

Vertebral artery thrombosis results in complete or partial occlusion of the vertebral artery and alteration of blood flow to the posterior cerebral circulation. Ischemia or infarction to structures supplied by these arteries may result in a range of symptoms. brainstem cerebellum occipital lo...
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Vertebral scalloping

Vertebral scalloping is a concavity to the posterior (or less commonly anterior) aspect of the vertebral body when viewed in a lateral projection. A small amount of concavity is normal, as is concavity of the anterior vertebral body (see vertebral body squaring). Posterior scalloping Causes of...
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Vestibulocochlear nerve

The vestibulocochlear nerve is the eighth cranial nerve and has two roles: innervation to the cochlea for hearing innervation to the vestibule for acceleration and balance senses Gross anatomy It emerges between the pons and the medulla, lateral to the facial nerve and nervus intermedius, pa...
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Vidian nerve

Vidian nerve, also known as the nerve of the pterygoid canal or nerve of the Vidian canal, is so named because of the canal in which is travels: the Vidian canal. It is formed by the confluence of two nerves: greater superfical petrosal nerve (from the geniculate ganglion of the facial nerve) ...
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Viking helmet appearance

The viking helmet appearance refers to the lateral ventricles in coronal projection in patients with dysgenesis of the corpus callosum. The cingulate gyrus is everted into narrowed and elongated frontal horns.  An alternative name is moose head appearance. 
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Viral encephalitides

Viral encephalitides are the result of brain parenchymal infection by a number of different viruses, many of which have similar presentations and imaging features. Specific diagnosis often requires PCR.  For viral infection of the meninges, please refer to the general article on viral meningiti...
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Viral meningitis

Viral meningitides correspond to a relatively common and self-limited type of CNS infection clinically diagnosed based on the cerebrospinal fluid analysis and proportionally more frequent in young children than adults. Enteroviruses represent nowadays the most common cause of viral meningitis fo...
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Visual agnosia

Visual agnosia is a special type of agnosia where patients are unable to recognize objects despite having knowledge about them and being able to visually perceive them. It typically occurs when there is damage to the ventral occipito-temporal pathway, such as in posterior cerebral atrophy (Bens...
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Visual hallucinations

Visual hallucinations are relatively uncommon, and can be due to a variety of 'organic' brain diseases, affecting a variety of regions of the brain.  The use of the term organic here is by convention, and should not be taken to imply absence of brain dysfunction in psychiatric illness Clinic...
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Visual pathway deficits

Visual pathway deficits are determined by the location of the lesion or pathology. Understanding of the visual system is paramount and provided the globe is normal, the field defects can be defined from anterior to posterior as: unilateral central scotoma optic nerve bitemporal hemianopsia o...
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Visual system

The visual system transmits visual information from the retina within the eyes to the primary visual cortex of the occipital lobe as well as the pretectal nuclei and superior colliculi of the midbrain. Gross anatomy Below the visual pathway is described from distal to proximal in a single hemi...
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Vitamin B1

Vitamin B1 (thiamine) is a water-soluble vitamin that is an important coenzyme for two reactions in the citric acid cycle (Kreb cycle). It therefore is vital for cellular ATP production, particularly in the central nervous system. Terminology Thiamine is the preferred official spelling, howeve...
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Vitamin B12 deficiency

Vitamin B12 deficiency, also known as hypovitaminosis B12 or hypocobalaminaemia, is not uncommon, with potentially serious sequelae if not adequately treated. Clinical presentation Vitamin B12 deficiency presents with a wide spectrum of dysfunction, from no symptoms at all (i.e. subclinical di...
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Vitamin B3

Vitamin B3 (niacin or nicotinic acid) is a water-soluble vitamin that is an important part of the coenzyme nicotinamide adenine dinucleotide (NAD+) which is involved in many reactions of cellular metabolism. Related pathology pellagra is the clinical syndrome of niacin deficiency, and may affe...
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Vitamin B6 excess

Vitamin B6 excess (hypervitaminosis B6) is caused by excessive consumption of supplemental pyridoxine, which is used as a therapeutic agent for several conditions.  Epidemiology This hypervitaminosis is almost exclusively seen in those taking pyridoxine as prescription medication, it remains i...
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Vitamin B9

Vitamin B9 (folate or folic acid) is a water-soluble vitamin that is vital for the synthesis of several amino acids, the purines adenosine and guanine and the pyrimidine thymine (three of the four nucleotide bases and hence critical for the synthesis of nucleic acids). The antimicrobial drug cl...
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Volcano sign (meningioma)

Volcano sign refers to the appearance of classical meningioma that resembels the appearance of volcano (viewed in cross-section MRI, parallel to dural attachment) in which there is triangular hyperostosis at the base of the meningioma (mountain) with the tumor being the cloud around it. The intr...
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Voltage gated potassium channel (VGKC) antibody encephalitis

Voltage gated potassium channel (VGKC) antibody encephalitis is an autoimmune encephalitis with antibodies against the voltage gated potassium channel. It is one of the most common forms of autoimmune limbic encephalitis in the absence of primary extra-CNS tumors. Autoimmune VGKC encephalitis ca...
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Von Hippel-Lindau disease

Von Hippel-Lindau (vHL) disease is characterized by the development of numerous benign and malignant tumors in different organs (at least 40 types 1) due to mutations in the VHL tumor suppressor gene on chromosome 3. Epidemiology The disease is rare with an estimated prevalence of 1:35,000-50,...
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Walker-Warburg syndrome

Walker-Warburg syndrome (WWS), sometimes known as HARDE syndrome, is an extremely rare lethal form of congenital muscular dystrophy. It is primarily characterized by: fetal hydrocephalus: almost always present neuronal migrational anomalies: agyria (cobblestone lissencephaly / lissencephaly ty...
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Wallerian degeneration

Wallerian degeneration is the process of antegrade degeneration of the axons and their accompanying myelin sheaths following proximal axonal or neuronal cell body lesions. It may result following neuronal loss due to cerebral infarction, trauma, necrosis, focal demyelination, or hemorrhage.  In...
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Wasp-waist sign (spine)

The wasp-waist sign is a radiographic appearance seen in patients with Klippel Feil syndrome. It results from fusion of the vertebral bodies such that the anteroposterior diameter at the level of the affected discovertebral joint is smaller than the diameter at the superior and inferior limits o...
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Watershed cerebral infarction

Watershed cerebral infarctions, also known as border zone infarcts, occur at the border between cerebral vascular territories where the tissue is furthest from arterial supply and thus most vulnerable to reductions in perfusion.  Epidemiology Watershed cerebral infarction account for 5-10% of ...
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Weber syndrome

Weber syndrome is a midbrain stroke syndrome that involves the cerebral peduncle and the ipsilateral fascicles of the oculomotor nerve 1-3. Clinical presentation ipsilateral CN III palsy contralateral hemiplegia or hemiparesis Pathology It is usually caused by an ischemic stroke, typically ...
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Wernicke aphasia

Wernicke aphasia, also known as receptive aphasia or fluent aphasia, is the inability to grasp the meaning of spoken or written words and sentences while producing connected speech is not greatly affected. Receptive aphasia is usually caused by injury to the dominant posterior temporal lobe (We...
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Wernicke encephalopathy

Wernicke encephalopathy, also referred as Wernicke-Korsakoff syndrome, is due to thiamine (vitamin B1) deficiency, and is typically seen in alcoholics. On imaging, it is commonly seen on MRI as areas of symmetrical increased T2/FLAIR signal involving the mammillary bodies, dorsomedial thalami, ...
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Wernicke's area

Wernicke's area (Brodmann area 22) is an area of the posterior temporal lobe in the dominant hemisphere concerned with the receptive components of speech. Gross anatomy Wernicke's area is located in the superior temporal gyrus, posterior to the posterior commissure line. Relations It is boun...
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WFNS grading system

The WFNS (World Federation of Neurosurgical Societies) grading system uses the Glasgow Coma Scale and presence of focal neurological deficits to grade the severity of subarachnoid hemorrhage. This grading system was proposed in 1988, and this is one of the accepted systems (although not consider...
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Whipple disease (neurological manifestations)

Neurological manifestations of Whipple disease are rare. Whipple disease may appear as a primary neurological disorder in rare cases. It is rarely found as a cause of progressive neurological deterioration in patients. It has been suggested that neurological involvement will eventually occur in...
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White cerebellum sign

White cerebellum sign, also called reversal sign or dense cerebellum sign, is encountered when there is a diffuse decrease in density of the supratentorial brain parenchyma, with relatively increased attenuation of the thalami, brainstem and cerebellum. This sign indicates irreversible brain dam...
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White epidermoid cyst

White epidermoids are a rare type of epidermoid cyst that do not follow the usual near-CSF density and signal intensity on CT and MR respectively. To make matters worse the literature uses the term inconsistently, although generally the 'white' refers to the T1 weighted imaging appearance.  Rad...
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White matter

The white matter is the substance of the brain and spinal cord that contains the fiber tracts of neuronal axons in the central nervous system. The term is due to the paler color of the lipid-rich myelin that encase the axons in the tracts compared to the grey matter, which contains predominantly...
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White matter buckling sign

The white matter buckling sign is helpful in distinguishing an extra-axial intracranial mass from an intra-axial one and represents the white matter projecting into gyri being compressed and displaced by the mass, even in the presence of edema (which would usually expand gyri, if the mass were i...
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White matter changes in HIV

White matter changes in HIV have overlapping appearances and varied in etiology. These can be divided into: primary effects of HIV opportunistic infection neoplasms vascular disease metabolic and nutritional disorders Primary effects of HIV HIV encephalitis Opportunistic infection cytom...
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White matter disorders

White matter diseases are a group of conditions that predominantly or significantly affect the white matter of the brain. They comprise a vast heterogeneous group and have a variety of appearances and presentations. They cause disease by altering the process of normal myelination.  Useful group...
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White matter tracts

White matter tracts in the brain, also known as white matter fibers, are classified into three categories: Projection tracts tracts connecting the cortex with other area in the CNS, e.g. deep nuclei, brainstem, cerebellum or spine may be efferent (motor) or afferent tracts (sensory) white ma...
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White matter tracts of the spinal cord

The spinal cord has numerous tracts of white matter that ascend and descend in the peripheral substance of the cord. They can be divided by their location and function: anterolateral columns anterior corticospinal tract medial longitudinal fasiculus spinothalamic tracts lateral spinothalami...
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WHO classification of CNS tumors

The WHO classification of CNS tumors is the most widely accepted system for classifying CNS tumors and was based on the histological characteristics of the tumor. Although the most recent version of the 'blue book' is the 4th edition from 2007, an update has been released in 2016 3, which should...
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WHO grading of CNS tumors

WHO (World Health Organization) grading of CNS tumors is based on histological characteristics such as cellularity, mitotic activity, pleomorphism, necrosis, and endothelial proliferation (neoangiogenesis). It is used in the WHO classification of CNS tumors.  It should be noted that at the time...
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WHO grading system for diffuse astrocytomas

 The WHO grading system is the most widely used system for grading diffuse astrocytomas (at the time of writing i.e. mid-2016) and is an adaptation of the now superseded St Anne-Mayo grading system (also known as the Daumas-Duport grading system).  Grade I is reserved for localised astrocytomas...
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Wildervanck syndrome

Wildervanck syndrome, also known as cervico-ocular-acoustic dysplasia, consists of the triad of: Klippel-Feil syndrome congenital ossicular anomalies: usually diffuse ossicular ankylosis and sensorineural deafness. Duane syndrome: an ocular motility disturbance due to fibrosis of the extraocu...
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Wilson disease

Wilson disease, also known as hepatolenticular degeneration, is a rare autosomal recessive disorder of copper metabolism affecting multiple systems.  Epidemiology Wilson disease is commonly found in Japan. It affects 1 in 30,000-40,000 individuals 12. Clinical presentation Clinical presentat...
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Wilson disease (CNS manifestations)

Wilson disease, also known as hepatolenticular degeneration, is a multisystem disease due to abnormal accumulation of copper. It is characterized by early onset liver cirrhosis with CNS findings most frequently affecting the basal ganglia and midbrain. This article aims to discuss the central n...
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Xanthomatous meningioma

Xanthomatous meningiomas are rare histological variants of meningiomas grouped into the subtype of metaplastic meningiomas, being WHO grade I tumors. They are characterized by cells with a lipid-filled vacuolated cytoplasm. Although reported numbers are too small to confirm that this is definit...
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Xenon-133

Xenon-133 is a radiopharmaceutical principally used when a performing VQ scan. Inhalation of this gas can also be used to assess cerebral blood flow. photon energy: 81 KeV physical half-life: 5.27 days biological half-life: 30 seconds normal distribution: lungs <15% of inhaled gas is absorb...
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Yasargil classification of vein of Galen aneurysmal malformations

The Yasargil classification is one of the two common systems for classifying vein of Galen malformations that is currently in use at the time of writing (mid 2016).  Classification type I: small pure cisternal fistula between the vein of Galen (voG) and either the pericallosal arteries (anteri...
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Yin-yang sign (solitary fibrous tumor)

The yin-yang sign is a radiologic appearance described in solitary fibrous tumor of the dura on MR. On T2-weighted images, these tumors have two separate solid components, one that is hyperintense and one that is iso- to hypointense relative to brain parenchyma. Histologically, the former repre...
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Y sign (epidural lipomatosis)

The Y sign refers to a common appearance in lumbar epidural lipomatosis where excess fat in the extradural space compresses the dural sac into the shape of the letter "Y". 
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Zabramski classification of cerebral cavernous malformations

The Zabramski classification of cerebral cavernomas has been proposed as a way of classifying cerebral cavernous malformations, and although not used in clinical practice it is useful in scientific publications that seek to study cavernous malformations. The classification was proposed in 1994 ...
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Zebra sign (cerebellum)

The zebra sign has been termed to describe the finding of layering of blood in amongst the folia of the cerebellum, particularly in the setting of remote cerebellar hemorrhage.1 This type of hemorrhage is characterized by a streaky pattern, like a zebra's stripes, due to blood spreading in the ...
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Zellweger syndrome

Zellweger syndrome (ZS), also known as the cerebrohepatorenal syndrome, is a multisystem metabolic abnormality. As the name implies it primarily affects the central nervous system (CNS), liver and kidneys.  Epidemiology The condition typically presents in neonates with poor feeding and/or seiz...
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Zimmerman-Laband syndrome

Zimmerman-Laband syndrome is a rare congenital syndrome, characterized primarily by gingival hypertrophy and skeletal abnormalities.  Pathology The molecular basis of the syndrome is currently unknown. An autosomal dominant mutation with high mutation rate and rare instances of germinal mosaic...

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