Articles

Articles are a collaborative effort to provide a single canonical page on all topics relevant to the practice of radiology. As such, articles are written and edited by countless contributing members over a period of time. A global group of dedicated editors oversee accuracy, consulting with expert advisers, and constantly reviewing additions.

1,981 results found
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Chronic inflammatory demyelinating polyneuropathy

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired demyelinating disease involving peripheral nerves, and is generally considered the chronic counterpart to Guillain-Barré syndrome (GBS).  Clinical presentation Patients typically present with a gradual and protracted (> 2 ...
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Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an uncommon and only recently described disorder characterised by infiltration of the brain by inflammatory cells. It has a predilection for the pons, with fairly characteristic curvilinea...
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Chronic otomastoiditis

Chronic otomastoiditis (COM) should be considered a separate entity from acute otomastoiditis, and is defined as persistent or recurrent inflammation of the middle ear and mastoid, lasting usually for a minimum of 12 weeks, and resulting in permanent perforation of the tympanic membrane. Pathol...
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Chronic traumatic encephalopathy

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is thought to result from mild repetitive head trauma.  Epidemiology The exact incidence and prevalence is unknown. It is most commonly seen in amateur and professional sports players where head contact is common (e.g...
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Cingulate gyrus

The cingulate gyrus lies on the medial aspect of the cerebral hemisphere. It forms a major part of the limbic system which has functions in emotion and behaviour. The frontal portion is termed the anterior cingulate gyrus (or cortex) 1-2.  Gross anatomy The cingulate gyrus extends from the sub...
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Cingulate sulcus

The cingulate sulcus is situated directly superior to the cingulate gyrus, which is formed by the medial surface of the cerebral hemisphere that is directly above the corpus callosum.
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Cingulate sulcus sign

The cingulate sulcus sign as been proposed as being useful as an MRI feature of idiopathic normal pressure hydrocephalus (NPH). It denotes the posterior part of cingulate sulcus being narrower than the anterior part. The divider between the anterior and posterior parts of the sulcus being a line...
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Circle of Willis

The Circle of Willis is an arterial polygon formed as the internal carotid and vertebral systems anastomose around the optic chiasm and infundibulum of the pituitary stalk in the suprasellar cistern. This communicating pathway allows equalization of blood-flow between the two sides of the brain,...
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Classification of cerebral vascular malformations

Cerebral vascular malformations encompass a large variety vascular lesions which differ in haemodynamics, structure and prognosis. Some can be life threatening (e.g. vein of Galen aneurysmal malformations, arteriovenous malformations) whilst others are almost always incidental and asymptomatic (...
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Classification of spinal meningeal cysts

Spinal meningeal cysts can be classified according to a system published by Nabor et. al 2: type I: extradural meningeal cyst without neural tissue type Ia: extradural spinal arachnoid cyst type Ib: sacral meningocele type II: extradural meningeal cyst containing neural tissue, e.g. Tarlov c...
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Classification system for malformations of cortical development

Classification system for malformations of cortical development organises a myriad of conditions according to one of three major underlying  mechanisms: abnormal cell proliferation abnormal neuronal migration abnormal cortical organisation As is to be expected a number of conditions fall out...
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Classification system for malformations of the cerebellum

Classification systems for malformations of the cerebellum are varied and are constantly being revised as greater understanding of the underlying genetics and embryology of the disorders is uncovered. A classification proposed by Barkovich et al in 2009 1 divides cerebellar malformations in two ...
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Classification system for midline abnormalities of the brain and skull

Classification systems for midline abnormalities of the brain and skull are varied and constantly changing as the underlying embryology and genetics are uncovered. A relatively simple and robust classification system is based on the location of abnormalities, always remembering that midline abno...
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Claude syndrome

Claude syndrome is one of the brainstem stroke syndromes in which there is infarction of the dorsomedial aspect of the midbrain secondary to occlusion of the small perforating branches of the posterior cerebral artery supplying this area 1-4. The infarction involves the medial aspect of red nucl...
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Claustrum

The claustrum is a vertical curved sheet of subcortical grey matter oriented sagittally between the white matter tracts of the external capsule and extreme capsule. It is lateral to the putamen and medial to the insular cortex. It is not part of the basal ganglia. There are lateral and medial t...
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Claw sign (mass)

The claw sign is useful in determining whether a mass arises from a solid structure or is located adjacent to it and distorts the outline. It refers to the sharp angles on either side of the mass, which the surrounding normal parenchyma forms when the mass has arisen from the parenchyma. As suc...
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Clear cell ependymoma

Clear cell ependymomas are a histological variant of ependymoma characterised by prominent perinuclear cytoplasmic clearing, reminiscent of oligodendrogliomas 1.  They are typically encountered in younger patients and usually in the supratentorial compartment 1.  They have a tendency to be qui...
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Clear cell meningioma

Clear cell meningiomas are a histological variant of meningioma with poorer prognosis and a higher rate of recurrence. They are therefore considered WHO grade 2 tumours, regardless of mitotic index, cellular atypia/anaplasia, or presence of brain invasion.  Epidemiology Clear cell meningiomas ...
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Clinically isolated syndrome

Clinically isolated syndrome (CIS) is the first episode suggestive of demyelination. It can either be monofocal (single lesion) or multifocal. Not all patients with CIS will go on to develop multiple sclerosis (MS) however if at presentation there are changes on MRI suggestive of MS, then the ch...
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Clinically unclassifiable parkinsonism

Clinically unclassifiable parkinsonism (CUP) is a term applied to patients who have some parkinsonism features, but who do not fulfil clinical criteria for a particular disorder such as:  Parkinson disease  progressive supranuclear palsy (PSP)  multiple system atrophy (MSA-P)   corticobasal ...
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Clival masses

The differential of a mass involving or arising from the clivus is a relatively narrow one and can be divided into whether the lesion arises from the skull base itself, from the intracranial compartment or from below the base of skull.   When evaluating the clivus it is important to compare the...
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CNS aspergillosis

CNS aspergillosis results from angioinvasive infection of the central nervous system by the fungus Aspergillus spp. Along with CNS cryptococcosis, it is one of the most common fungal opportunistic infections of the central nervous system. Epidemiology The disease predominates in immunocompromi...
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CNS capillary telangiectasia

CNS capillary telangiectasiae(s) are small, asymptomatic low flow vascular lesions of the brain.  Epidemiology As these lesions are asymptomatic, diagnosis usually matches the age of first imaging with MRI, and as such are most frequently found in middle-aged and elderly adults. Their incidenc...
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CNS cryptococcosis

CNS cryptococcosis results from infection of the central nervous system with the yeast-like fungus Cryptococcus neoformans. It is the most common fungal infection and second most common opportunistic infection of the central nervous system. For a general discussion of infection with this organi...
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CNS infectious diseases

This article aims to be a collection of articles that represent the central nervous system infectious diseases. There will be some overlap between articles as they are listed and discussed in a mixture of anatomical and aetiological classification.   Terminology It is important to remember tha...
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CNS lymphoma

CNS lymphoma refers to the involvement of the central nervous system with lymphoma. It can be broadly divided into primary and secondary, with a number of special types of also recognised.  primary CNS lymphoma (PCNSL) intravascular lymphoma MALT lymphoma of the dura 5 secondary CNS lymphoma...
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CoA synthase protein associated neurodegeneration

CoA synthase protein associated neurodegeneration (CoPAN) is a type of neurodegeneration with brain iron accumulation (NBIA). Clinical presentation Patients typically present with a variety of symptoms including spastic-dystonic paraparesis, Parkinsonism, cognitive impairment, obsessive-compul...
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COACH syndrome

The acronym COACH describes a syndrome associated with: C - cerebellar vermis defect (Joubert syndrome) O - oligophrenia A - ataxia C - coloboma H - hepatic fibrosis Epidemiology There only as little as 11 cases having been reported in the English medical literature....
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Coalescent mastoiditis

Coalescent mastoiditis is simply the term given to acute otomastoiditis when mucoperiosteal disease extends to involve the bone. The septae which normally separate one mastoid air cell from another are resorbed. This change is only easily appreciated on thin section bone-algorithm through the te...
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Coccidioidal meningitis

Coccidioidal meningitis refers to central nervous system involvement of the dimorphic fungus Coccidioides spp, mainly Coccidioides immitis and Coccidioides posadasi. Epidemiology Coccidioidomycosis is endemic to many parts of North, Central, and South America 1. It usually only manifests as co...
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Coccidioidomycosis

Coccidioidomycosis refers to an infection caused by the dimorphic fungus Coccidioides spp, usually localised to the lungs. This disease is not to be confused with the similarly named paracoccidioidomycosis. Epidemiology The most common forms of Coccidioides spp are Coccidioides immitis and Coc...
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Cochlear implant

Cochlear implants (CI) are a surgically implanted electronic device that provides a sense of sound to a person who is profoundly deaf or severely hard of hearing. Unlike conventional hearing aids, the cochlear implant does not amplify sound, but works by directly stimulating any functioning audi...
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Cochlear incomplete partition

Cochlear incomplete partition is a group of cochlear malformations associated with variable degree of inner ear architecture defects. It is classified in three groups: cochlear incomplete partition type I (IP-I) a severe form of IP-I is known as cystic cochleovestibular malformation cochlear...
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Cochlear incomplete partition type I

Cochlear incomplete partition type I  (IP-I) is a type of cochlear anomaly associated with sensorineural hearing loss. Radiographic features CT The main findings on CT are: absent modiolus absent interscalar septum wide (most common) or normal cochlear nerve canal Absence of these structu...
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Cochlear incomplete partition type II

Cochlear incomplete partition type II  (IP-II) is a type of cochlear anomaly associated with sensorineural hearing loss. It should not be confused with Mondini anomaly, which his an historic term for a combination of IP-II and large vestibular aqueduct. Radiographic features CT On CT, the co...
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Cockayne syndrome

Cockayne syndrome is a rare autosomal recessive dysmyelinating disease. Cockayne syndrome is classified among the childhood leukodystrophies, and brain imaging findings are cardinal features suggesting the diagnosis of Cockayne syndrome. Previously published Cockayne syndrome imaging studies hav...
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Coffin-Siris syndrome

Coffin-Siris syndrome, first described in 1970, is a rare genetic abnormality.  Epidemiology It occurs more frequently in females (with a M:F of ~4:1). Pathology Genetics It is thought most likely to relate to a gene on chromosome 7, however its exact location has yet to be determined. Cli...
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Cognard classification of dural arteriovenous fistulas

The Cognard classification of dural arteriovenous fistulas correlates venous drainage patterns with increasingly aggressive neurological clinical course. It was first described in 1995 1 and at the time of writing (July 2016) is probably the most widely used classification system for dural arter...
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COL4A1 brain small-vessel disease

COL4A1 brain small-vessel disease is an autosomal dominant monogenic COL4A1-related disorder that primarily causes cerebral small vessel disease. Epidemiology The exact prevalence is unknown, but the condition is likely under-diagnosed. Clinical presentation The clinical presentation is vari...
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COL4A1-related disorders

COL4A1-related disorders are a group of autosomal dominant disorders caused by a mutation in the COL4A1 gene. Epidemiology The exact prevalence is unknown, but the group of disorders is considered to be under-recognised, especially asymptomatic variants 1. Clinical presentation The clinical ...
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COLD syndrome

COLD syndrome is the acronym for the concurrent diagnosis of Cowden syndrome and Lhermitte-Duclos disease. It has been suggested that COLD syndrome should be considered a phakomatosis 1. 
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Collateral sulcus

The collateral sulcus, also known as the medial occipitotemporal sulcus, runs anteroposteriorly on the inferior surface of the temporal lobe and occipital lobe. Anteriorly it is sometimes continuous with the rhinal sulcus 1-3.  Anteriorly, it separates the fusiform gyrus laterally, from the par...
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Coloboma

Coloboma is collective term encompassing any focal discontinuity in the structure of the eye, and should not be confused with staphylomas, which are due to choroidal thinning.  Pathology Most commonly colobomas are due to failure of closure of the choroidal fissure posteriorly. Typically colob...
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Colpocephaly

Colpocephaly is a descriptive term to a disproportionate prominence of the occipital horns of the lateral ventricles. It can result from a wide range of congenital insults. Clinical presentation Patient may present with motor abnormalities, cognitive deficit, visual abnormalities, and seizures...
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Column of Burdach

The column of Burdach, also known as the cuneate fasciculus or fasciculus cuneate, represents the lateral portion of the dorsal columns and carries input from between and including C1 and T6 1.  Function The cuneate fasciculus is responsible for transmitting vibration, conscious proprioception...
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Column of Goll

The column of Goll, also known as the gracile fasciculus or fasciculus gracilis, represents the medial portion of the dorsal columns and carries input from below and including T7 1. Function The gracile fasciculus is responsible for transmitting vibration, conscious proprioception, and fine (d...
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Combined cerebral oedema

Combined cerebral oedema is a type of cerebral oedema in which there is a mixed pattern of both cytotoxic and vasogenic cerebral oedema. It is usually associated with severe systemic damage, such as with: hypertensive crises severe sepsis / severe inflammatory condition hypoxic-ischemic ...
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Commissures of the brain

There are a number of white matter tracts that cross the midline, connecting the two cerebral hemispheres. These are known as commissures and include: corpus callosum anterior commissure hippocampal commissure (psalterium) habenular commissure posterior commissure supraoptic commissures G...
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Communicating hydrocephalus

Communicating hydrocephalus is a type of hydrocephalus where CSF is able to leave the ventricular system.  Terminology Communicating hydrocephalus is commonly used as the opposite of obstructive hydrocephalus which leads to much unnecessary confusion, as most causes of communicating hydrocepha...
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Complications of cranial radiotherapy

Complications of cranial radiation therapy are fairly common, particularly in long term survivors, and especially in paediatric patients. Cranial radiotherapy is used for a variety for a brain tumours, either in isolation or in combination with concurrent chemotherapy. Complications from irradi...
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Concurrent suprasellar and pineal region lesions (differential)

Concurrent suprasellar and pineal region lesions have a relatively short differential to be considered, including:  germinoma other germ cell tumours choriocarcinoma embryonal cell carcinoma yolk sac tumour (endodermal sinus tumour) primary CNS lymphoma cerebral metastasis quadrilateral ...
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Condylar canal

The condylar canal, or canalis condylaris, is a skull base canal in the posterior cranial fossa, located in the condylar fossa. Summary location: in the condylar fossa of the posterior cranial fossa, posterior to the occipital condyles contents emissary veins, connecting the sigmoid sinus to...
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Confluence of sinuses

The confluence of sinuses, also known as the torcula or torcular Herophili is the site of the confluence of: superior sagittal sinus straight sinus occipital sinus transverse sinuses The anatomy is highly variable and three types can be distinguished: type 1: superior sagittal sinus drains...
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Congenital absence of the internal carotid artery

Congenital absence of the internal carotid artery (ICA) is a rare anomaly that occurs in less than 0.01% of the population. It encompasses agenesis, aplasia, and hypoplasia 1. The most common type of collateral flow is through the circle of Willis, through the anterior communicating artery (ACO...
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Congenital anomalies of the posterior atlas arch

Congenital anomalies of the posterior arch of the atlas (C1) are relatively common anomalies. They may range from partial defects presenting as clefts to complete absence of the posterior arch (aplasia). These anomalies are classified according to Currarino (see below). It should not be confuse...
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Congenital calvarial defects

Congenital calvarial defects are a group of disorders characterised by congenital calvarial bone defects that vary in severity. Radiographic features CT with 3D shaded surface reformats is the best imaging tool as it demonstrates calvarial defects and bone margins: parietal foramina parietal...
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Congenital cerebral toxoplasmosis

Congenital cerebral toxoplasmosis is a manifestation of congenital toxoplasmosis and refers to development of cerebral toxoplasmosis in the fetus through maternal transmission. Please refer on congenital toxoplasmosis to a broad discussion on epidemiology and pathology.  Radiographic features ...
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Congenital cholesteatoma

Congenital cholesteatomas are identical to epidermoid cysts, differing only in name and location.  Pathology They are intraosseous inclusions of ectoderm, and are therefore comprised of keratin debris and cholesterol. Characteristically, they are located at the petrous apex. In contrast middle...
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Congenital cytomegalovirus infection

Congenital cytomegalovirus infection results from intra-uterine fetal infection by cytomegalovirus (CMV).  Epidemiology CMV is the most common cause of intra-uterine infection and most common cause of congenital infective and brain damage, occurring in 0.2-2.4% of live births.  Antibodies to ...
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Congenital facial palsy

A congenital facial palsy (CFP) is an uncommon cause of neonatal asymmetric crying facies, which are more frequently due to absence or hypoplasia of the depressor anguli oris muscle, often associated with other congenital anomalies.  Epidemiology CFP are reported with an incidence of ~0.2% of ...
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Congenital muscular dystrophies (central nervous system manifestations)

Congenital muscular dystrophies (CMD) are a heterogeneous group of autosomal recessive myopathies presenting at birth with hypotonia, delayed motor development, and early onset of progressive muscle weakness, confirmed with a dystrophic pattern on muscle biopsy.  Clinical presentation There is...
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Congenital ossicular anomalies

Congenital anomalies of the ossicles are most frequently associated with external ear abnormalities also, although they can occur in isolation.  They cause conductive hearing loss (CHL). When bilateral they are most frequently genetic, with autosomal dominant inheritance, whereas unilateral a...
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Congenital spinal meningocoele

Congenital spinal meningocoeles are developmental anomalies of meningothelial elements displaced into the skin and subcutaneous tissues. Please refer on menigocoele article for a broad overview of all types of this condition.  Pathology It is defect of the neural tube, an embryonic structure ...
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Congenital syndromes associated with enlarged ventricles

Congenital ventriculomegaly can have large number of syndromic associations  Common acrocephalosyndactylies Apert syndrome Pfeiffer syndrome acrocephalopolysyndactylies Crouzon syndrome  achondroplasia fetal alcohol syndrome lissencephaly osteopetrosis Sotos syndrome  X-linked hydro...
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Conjoined nerve root

A conjoined root is a type of developmental anomaly involving a nerve root. It is the most common nerve root developmental anomaly of the cauda equina being twice as common as two roots in the same foramen, the next most common anomaly 1. Epidemiology The incidence in cadaveric studies is abo...
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Connatal cyst

Connatal cysts, also known as coarctation of the lateral ventricles or frontal horn cysts, are cystic areas adjacent to the superolateral margins of the body and frontal horns of the lateral ventricles and are believed to represent a normal variant. Epidemiology Incidence of 0.7% in low birth ...
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Conus medullaris

The conus medullaris is the terminal end of the spinal cord. Gross anatomy After the cord terminates, the nerve roots descend within the spinal canal as individual rootlets, collectively termed the cauda equina. The conus medullaris most commonly terminates at the L1/2 intervertebral disc leve...
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Conus medullaris syndrome

Conus medullaris syndrome is caused by an injury or insult to the conus medullaris and lumbar nerve roots. It is a clinical subset of spinal cord injury syndromes. Injuries at the level of T12 to L2 vertebrae are most likely to result in conus medullaris syndrome. Pathology The conus medullari...
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Convexal subarachnoid haemorrhage

Convexal subarachnoid haemorrhages (cSAH) are nontraumatic intracranial haemorrhages that occur within the surface sulci of the brain (c.f. basal cisternal distribution of aneurysmal SAH). There are various causes of convexal SAH, some of which include: dural venous sinus thromboses cortical ...
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Convolutional markings

Convolutional markings are normal impressions of the gyri on the inner table of the skull, seen predominantly posteriorly. If they are pronounced and over the more anterior parts of the skull, then this is referred to as a copper beaten skull and raises the possibility of raised intracranial pre...
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Copper beaten skull

Copper beaten skull, also known as beaten brass skull, refers to the prominence of convolutional markings (gyral impressions on the inner table of the skull) seen throughout the skull vault. Clinical presentation The appearance of copper beaten skull is associated with raised intracranial pres...
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Copper deficiency myeloneuropathy

Copper deficiency myeloneuropathy is rare but increasingly recognised as a cause of neurological impairment, presenting similarly to subacute combined degeneration of the cord secondary to B12 deficiency.  Clinical presentation Patients typically present with a proprioceptive loss, due to dors...
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Cord sign (dural sinus thrombosis)

The cord sign refers to cordlike hyperattenuation within a dural venous sinus on non-contrast enhanced CT of the brain due to dural venous sinus thrombosis. The sign is most commonly seen in the transverse sinus because along the origin of the tentorium it runs approximately in the axial plane s...
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Corona radiata

The corona radiata refer to a pair of white matter tracts seen at the level of the lateral ventricles. Superiorly they are continuous with the centrum semiovale. Inferiorly these tracts converge as the internal capsule.
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Corpora quadregemina

The corpora quadrigemina (Latin for "quadruplet bodies") are the four colliculi, two inferior and two superior, that sit on the quadrigeminal plate on the posterior surface of the midbrain. The corpora quadrigemina are reflex centres involving vision and hearing: superior colliculi: involved i...
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Corpus callosum

The corpus callosum (CC) is the largest of the commissural fibres, linking the cerebral cortex of the left and right cerebral hemisphere. It is the largest fibre pathway in the brain. Gross anatomy The corpus callosum is approximately 10 cm in length and is C-shaped, like most of the supratent...
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Corpus callosum hyperintensity (mnemonic)

A useful mnemonic to remember the causes of corpus callosum hyperintensity is: I MADE A PHD Mnemonic I: infections (e.g. tuberculosis, varicella, rotavirus, HSV)  M: Marchiafava-Bignami syndrome A: AIDS encephalopathy D: diffuse axonal injury and diffuse vascular injury E: epilepsy  A: a...
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Corpus callosum impingement syndrome

Corpus callosum impingement syndrome (CCIS) is caused by impingement of the corpus callosal fibers against inferior free margin of the falx cerebri due to longstanding and severe hydrocephalus and stretching of the lateral ventricles. this results in ischaemia and eventually atrophy of the neura...
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Corpus callosum parts (mnemonic)

A useful mnemonic to help remember the parts of the corpus callosum, from anterior to posterior, is: Remember Genu Before Splenium Remember G Before S (as G comes before S alphabetically) Mnemonics R: rostrum G: genu B: body (trunk) S: splenium
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Corpus striatum

The corpus striatum is a collective name given to the caudate nucleus and lentiform nucleus. History and etymology The term originates from the Latin "striatus", meaning "striped", referring to the caudatolenticar bridges of grey matter crossing the internal capsule from the putamen to the cau...
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Cortical blindness syndrome

Cortical blindness is a condition resulting from lesions in the primary visual cortex (V1) characterised by visual impairment but with an intact anterior visual pathway (normal pupillary reflexes and fundal appearance). Clinical features The degree of visual impairment is related to the extent...
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Cortical laminar necrosis

Cortical laminar necrosis, also known as pseudolaminar necrosis, is necrosis of neurons in the cortex of the brain in situations when supply of oxygen and glucose is inadequate to meet regional demands. This is often encountered in cardiac arrest, global hypoxia and hypoglycaemia.  Terminology ...
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Cortical tubers

Cortical tubers or subcortical tubers (with involvement of the underlying white matter) are a common finding in tuberous sclerosis, present in 95-100% of cases 1. These benign hamartomatous lesions can be epileptogenic foci, and are important to diagnose on imaging (typically MRI) as they can a...
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Cortical vein sign

The cortical vein sign refers to the presence of superficial cortical veins seen on MRI and CT (particularly with contrast injection) traversing an enlarged subarachnoid space, differentiating it from the similar radiological appearance of a subdural hygroma. Although initially proposed as a me...
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Cortical vein thrombosis

Cortical vein thrombosis, also known as superficial cerebral vein thrombosis, is a subset of cerebral venous thrombosis involving the superficial cerebral veins besides the dural sinus, often coexisting with deep cerebral vein thrombosis or dural venous sinus thrombosis. It has different clinica...
Article

Cortically-based brain tumours (mnemonic)

A handy mnemonic to recall cortically-based brain tumours is: PDOG Mnemonic P: pleomorphic xanthoastrocytoma D: dysembryoplastic neuroepithelial tumour (DNET); desmoplastic infantile astrocytoma and ganglioglioma O: oligodendroglioma G: ganglioglioma
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Corticobasal degeneration

Corticobasal degeneration (CBD) is an uncommon neurodegenerative disease and is one of the subset of taupathies. Epidemiology The vast majority of cases are sporadic, although a number of familial cases have been described 2. Patients are usually in the fifth to seventh decades of life5, with ...
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Corticorubral tract

The corticorubral tract contains neurons that connect the primary motor and sensory areas to the red nucleus. The rubrospinal tract then descends through the spinal cord.  The tract is thought to excite flexor muscles and inhibit extensor muscles. Gross anatomy Central connections The corti...
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Corticospinal tract

The corticospinal tract is a descending neural pathway primarily concerned with motor function extending from the motor cortex down to synapse with motor neurones of the spinal cord.  Gross anatomy Central connections Corticospinal fibres arise from neurones in the cerebral cortex. Most of th...
Article

Cotton wool appearance (bone)

The cotton wool appearance is a plain film sign of Paget disease and results from thickened, disorganized trabeculae which lead to areas of sclerosis in a previously lucent area of bone, typically the skull. These sclerotic patches are poorly defined and fluffy. See also Other Paget disease re...
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Coup de poignard of Michon

Coup de poignard of Michon refers to spinal subarachnoid haemorrhage, usually as a result of a spinal AVM. Presentation is with sudden excruciating back pain, akin to being stabbed with a dagger (poignard = french for dagger). It is the corollary of the thunderclap headache.
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Coup-contrecoup injury (brain)

A coup-contrecoup injury is a term applied to head injuries and most often cerebral contusions and traumatic subarachnoid haemorrhage. It refers to the common pattern of injury whereby damage is located both at the site of impact (often less marked) and on the opposite side of the head to the po...
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Cowdry bodies

Cowdry bodies are neuronal intranuclear inclusions seen in Herpes simplex virus infections.

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