Cystic bronchiectasis is one of the less common morphological forms of bronchiectasis. It may be present on its own or may be occur in combination with other forms of bronchiectasis.
For a general discussion, please refer to the article on bronchiectasis.
It is character...
Cystic fibrosis (CF) is an autosomal recessive genetic disease that affects the exocrine function of the lungs, liver, pancreas, and small bowel resulting in progressive disability and multi-system failure. This article is a general discussion of the disease. Each organ system will be discussed ...
Pulmonary manifestations of cystic fibrosis are some of the best known in cystic fibrosis (CF). This is partly because the lungs are often severely affected and the cause of significant morbidity and mortality.
For general discussion of cystic fibrosis, and a discussion of its other manifestat...
Cystic hygroma, also known as cystic or nuchal lymphangioma, refers to the cystic variety of congenital lymphangioma which, most commonly, occur in the cervicofacial regions, particularly at the posterior cervical triangle.
They usually occur in the fetal/infantile and pediatric...
Cystic lung disease is an umbrella term used to group the conditions coursing with multiple lung cysts.
A lung cyst is a gas-filled structure with perceptible wall typically 1 mm in thickness but can be up to 4 mm. The diameter of a lung cyst is usually <1 cm. By conventional defini...
Cystic lesions in pediatric patients are usually congenital lesions and, as such, can be seen antenatally and following delivery.
These congenital lesions are predominantly covered by the overarching diagnosis of bronchopulmonary foregut malformation. This is a ...
The differential diagnosis for cystic masses of the mediastinum include:
esophageal duplication cyst
cystic teratoma of mediastinum
cystic degeneration of an intrathoracic tumor
Cystic or necrotic appearing lymph nodes can be caused by a number of infectious, inflammatory or malignant conditions:
squamous cell carcinoma metastases
plasmacytoid T-cell leukemia
acute myeloid leukemia
herpes simplex lymphadenit...
Cystic pulmonary metastases are atypical morphological form on pulmonary metastases where lesions manifest as distinct cystic lesions. It is slightly different form the term cavitating pulmonary metastases in that the lesions are extremely thin walled.
It has been reported with many ...
A cystic retroperitoneal lesion can carry a relatively broad differenital which includes:
retroperitoneal cystic lymphangioma
retroperitoneal mucinous cystadenoma
retroperitoneal cystic teratoma
retroperitoenal cystic mesothelioma
pseudomyxoma retroperitonei with cystic change
Cytomegalovirus (CMV) pneumonia is a type of viral pneumonitis and occurs due infection with cytomegalovirus (CMV), which is a member of the Herpetoviridae family.
CMV infection is particularly important in those who are immunocompromised (e.g. those with AIDS / allogenic bone mar...
The dark bronchus sign is the appearance of a relatively darker bronchus as compared to adjacent ground glass opacity. If the ground glass opacity progresses to consolidation, air bronchograms will be visualized.
This sign is useful to identify diffuse ground glass opacity on HRCT chest in cas...
The DeBakey classification, along with the Stanford classification, is used to separate aortic dissections into those that need surgical repair, and those that usually require only medical management.
The DeBakey classification divides dissections into 1-5:
type I: involves asc...
A mnemonic used to remember the DeBakey classification 1 is:
B: both ascending and descending aorta (type I)
A: ascending aorta (type II)
D: descending aorta (type III)
The deep sulcus sign on a supine chest radiograph raises suspicion of a pneumothorax.
On a supine plain chest film (common in intensive care units or as part of a trauma radiograph series), it may be the only suggestion of a pneumothorax because air collects anteriorly and basally, within the n...
Dehiscence is a general term referring to 'splitting open' and is used in a variety of contexts in medicine generally and radiology more specifically.
The two most common usages are:
splitting open of a wound (e.g. sternal dehiscence)
loss of bone separating one structure from another (e.g. ...
Dendriform (or dendritic) pulmonary ossification is a rare morphological subtype of pulmonary ossification where the thin branching calcified lines on CT resemble a dendrite. They principally have a peripheral and basal distribution and is thought to be metaplastic in etiology.
The dense hilum sign suggests a pathological process at the hilum or in the lung anterior or posterior to the hilum. Malignancy, especially lung cancer, should be suspected.
On a well-centred chest posteroanterior (PA) radiograph the density of the hilum is comparable on ...
The dependent viscera sign is one of the signs of diaphragmatic rupture on axial CT or MR images, where herniated viscera lie against the posterior thoracic wall in a dependent position, as they are no longer supported by the diaphragm.
collar sign (or hourglass sign)
Descending necrotizing mediastinitis is a severe form of mediastinitis and refers to an acute, polymicrobial infection of the mediastinum that usually spreads downwards from oropharyngeal, cervical, and odontogenic infection.
diabetes: more than one-third of patients...
Desquamative interstitial pneumonia (DIP) is an interstitial pneumonia closely related to and thought to represent the end stage of respiratory bronchiolitis interstitial lung disease (RB-ILD). It is associated with heavy smoking.
It is considered one of the rarest of idiopathic i...
Dextrocardia is a congenital cardiac malrotation in which the heart is situated on the right side of the body (dextroversion) with the apex pointing to the right.
Dextrocardia is believed to occur in approximately 1 in 12,000 people 2.
There are two main types of dextr...
As a part of international evidence-based guidelines adopted by a collaborative effort of the American Thoracic Society (ATS), the European Respiratory Society (ERS), the Japanese Respiratory Society (JRS), and the Latin American Thoracic Association (ALAT), specific diagnostic HRCT criteria for...
In 2018, the Fleischner Society provided updated diagnostic HRCT criteria for usual interstitial pneumonia (UIP) pattern based on literature review and the expert opinion of members. As a part of this white paper, diagnostic HRCT criteria for usual interstitial pneumonia (UIP) pattern were updat...
The diaphragm is the dome-shaped muscle that separates the thoracic cavity from the abdominal cavity, enclosing the inferior thoracic aperture.
The muscular fibers of the diaphragm originate around the circumference of the inferior thorax and converge to a common insertion point ...
The diaphragmatic apertures are a series of apertures that permit the passage of structures between the thoracic and abdominal cavities. There are three main apertures:
aortic hiatus (T12) (not a true aperture)
esophageal hiatus (T10)
vena caval foramen (T8)
The vertebral levels of these ape...
A useful mnemonic to remember the thoracic spinal levels at which the three major structures pass through the diaphragmatic apertures is:
I 8 10 eggs at 12 - where 8 is a homophone for 'ate' and the 'e' in eggs is for the US spelling of esophagus
I 8: inferior vena cava at T8
Diaphragmatic eventration refers to an abnormal contour of the diaphragmatic dome. It typically affects only a segment of the hemidiaphragm, compared to paralysis/weakness where the entire hemidiaphragm is typically affected.
Diaphragmatic eventration is congenital in nature and due...
Diaphragmatic hernias are defined as either congenital or acquired defects in the diaphragm.
Demographics and etiology
There are two main types of congenital diaphragmatic hernia (CDH)s which are uncommon yet distinct entities that usually occur on the left side (80%) of the diaphr...
Diaphragmatic paralysis can be unilateral or bilateral.
Clinical features are highly variable according to underlying aetiological factor:
unilateral paralysis: asymptomatic in most of the patients as the other lung compensates
may have dyspnea, headaches, fatigue, inso...
Diaphragmatic rupture often results from blunt abdominal trauma. The mechanism of injury is typically a motor-vehicle collision.
Given that the most common mechanism is motor vehicle collisions, it is perhaps unsurprising that young men are most frequently affected. The estimated ...
A small cardiothoracic ratio (CTR) as defined as <42%/0.42 when assessed on a PA chest radiograph, and can be due to number of entities:
adrenal insufficiency, e.g. Addison disease
asthmatic paroxysm ...
An anterosuperior mediastinal mass can be caused by neoplastic and non-neoplastic pathology. As their name suggests, they are confined to the anterior mediastinum, that portion of the mediastinum anterior to the pericardium and below the level of the clavicles.
The differential diagnosis for a...
Diffuse alveolar damage (DAD) is a common manifestation of drug-induced lung injury that results from necrosis of type II pneumocytes and alveolar endothelial cells.
Affected patients present with dyspnea, cough, and occasionally fever. Diffusion capacity of the lung for ...
Diffuse alveolar hemorrhage (DAH) is a subset of diffuse pulmonary hemorrhage when bleeding is diffuse and directly into the alveolar spaces. It can occur in a vast number of clinical situations and can be life-threatening.
Blood tends to fill alveolar spaces at multiple sites.
Diffuse ground-glass nodules can arise from many causes. These include:
atypical infections (especially in immunosuppressed patients) 1,3
pneumocystis jirovecii pneumonia
pulmonary herpes simplex infection
pulmonary respiratory syncytial viral infection
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is an extremely rare pulmonary disorder at the benign end of the neuroendocrine cells proliferation spectrum. It is mainly seen in non-smoker middle age females with a history of chronic cough or asthma.
On imaging, it is c...
Diffuse panbronchiolitis (DPB) or Asian panbronchiolitis is an idiopathic progressive inflammatory small airway obstructive lung disease.
There is a striking predilection in patient from East Asia (e.g. Japan, Korea, China). It tends to present around the 3rd to 6th decade and oft...
Diffuse pleural thickening refers to a morphological type of pleural thickening. It can occur from malignant as well as nonmalignant causes, which include:
diffuse pleural fibrosis / fibrothorax 6
asbestos related pleural disease: typically seen a continuous sheet of pleural thickening often i...
Diffuse pulmonary hemorrhage (DPH) is a subtype of pulmonary hemorrhage where bleeding into the lung is diffuse. If the bleeding is into the alveolar spaces this can be further subclassified as diffuse alveolar hemorrhage (DAH).
While the exact presentation can vary is ha...
Diffuse pulmonary lymphangiomatosis (DPL) is a rare condition characterized by diffuse proliferation of anastomosing lymphatic channels (lymphangiomas).
There is no recognised gender predilection. It typically manifests in children and young adults.
Diffuse pulmonary meningotheliomatosis a rare condition manifested by minute pulmonary meningothelial nodules (MPMNs) scattered throughout the lungs.
There may be an increased female predilection and they tend to peak around the 5th to 7th decades of life at time of detection.
Diffuse pulmonary nodules are usually seen as multiple pulmonary nodular opacifications on a HRCT chest scan. They can signify disease processes affecting either the interstitium or the airspace. They can range from a few millimetres to up to 1 cm and when very small and numerous there can be so...
A number of differentials must be kept in mind while approaching diffuse pulmonary nodules. Interpretation is easier if nodules are the only abnormality.
These differentials can be narrowed down based on the several criteria:
Based on appearance
Diffuse pulmonary parenchymal amyloidosis is considered the least common form of pulmonary amyloidosis 6.
Unlike the nodular form, patients tend to be more symptomatic and often have symptoms of cough and shortness of breath. The most common presentation in this form ten...
Conditions associated with diffuse tracheal narrowing or collapse include (in alphabetical order):
chronic obstructive pulmonary disease (COPD): saber sheath trachea
granulomatosis with polyangiitis
tracheobronchial tuberculosis 3
tracheomalacia/tracheobronchomalacia (due to col...
Diffusing capacity of the lungs for carbon monoxide (often abbreviated as DLCO) is a measure that determines how much oxygen travels from the alveoli of the lungs to the bloodstream. It is an index of the surface area available for gas exchange.
It becomes decreased in situations such as
A ditzel is an informal term widely used by radiologists to refer to indeterminate small pulmonary nodules 1.
History and etymology
The etymology of the term ditzel is disputed. It might be derived from the American term 'ditzy' meaning silly or inane, but there is a lack of good evidence for...
Diverticula are outpouchings of a hollow viscus and can be either true or false.
Occasionally a diverticulum is used in a more general sense to mean the outpouching of other anatomical structures, e.g. frontal intersinus septal cells are hypothesised to form as diverticula from the frontal sinu...
Doege-Potter syndrome is a non-islet cell tumor hypoglycemia, secondary to a solitary fibrous tumor (SFT). It is rare, and more associated with malignant SFTs.
Domestically acquired particulate lung disease (DAPLD) or hut lung is a pneumoconiosis due to exposure from smoke from biomass fuel used in cooking in an enclosed space.
Typically women who present with symptoms of a pneumoconiosis without the history of occupational exposure 2,3...
A "dot in box" appearance is a pattern that has been described with pulmonary lymphangitis carcinomatosis. The interlobular septal thickening from lympangitis forms polygonal arcades accounting for the box while the prominence of the centrilobular bronchovascular bundle is thought to represent ...
Double aortic arch is the most common symptomatic type of the aortic arch variant. It may account for up to 50-60% of vascular rings.
Double aortic arch is mostly diagnosed in childhood due to symptoms related to esophageal and/or tracheal obstruction. Respiratory symptom...
The double artery sign refers to the appearance of a non-dilated mucus-filled bronchus adjacent to a pulmonary artery producing the appearance of a "double artery" on CT chest. This sign is considered a feature of a central endobronchial lesion such as a mucus plug or neoplasm.
The double diaphragm sign is one of several radiological signs seen with a pneumothorax in a supine patient.
Supine films are commonly performed in unwell patients, particularly in the ICU. In a supine patient with a pneumothorax, air may outline the anterior portions of the hemidiaphragm and c...
The double lumen cannula enables veno-venous extracorporeal membrane oxygenation (VV ECMO) to patients with severe respiratory failure. It is often used as a bridge to lung transplant.
The cannulation is usually performed via the right jugular vein. This position allows the patients to stay aw...
A double lumen endotracheal tube is a type of intubation device where there are two lumens.
It is designed to isolate the lungs from one another anatomically and/or physiologically:
anatomical lung separation: isolation of diseased lung from contaminating the non-diseased lung
The double lung point sign refers to a sharp boundary found between relatively aerated superior lung fields and coalescent "B‐lines" (representing interstitial edema) in the basal lung fields, with a reported sensitivity of 45.6%-76.7% and a specificity of 94.8%-100% 1,3 in diagnosing transient ...
Drowning is one of the most prevalent causes of non-natural death. According to the World Health Organization (WHO), an estimated 360,000 annual deaths occur due to drowning.
This article concerns itself with postmortem appearances in fatalities from drowning. For non-fatal pulmonary changes pl...
Drug and toxin induced pulmonary hypertension is one of the causes of pulmonary arterial hypertension. It falls under group 1.3 under the Dana point classification system of pulmonary hypertension.
A wide range of difference drugs have been associated with developing pulmonary hyper...
Drug-induced lung disease can result from a number of agents and can have a myriad of presentations, ranging from adult respiratory distress syndrome type picture to established pulmonary fibrosis.
Due to this, it can be extremely difficult to pinpoint the offending agent on imaging appearances...
Drug rash with eosinophilia and systemic symptoms (DRESS) is a syndrome reflecting a marked hypersensitivity reaction to drugs or medications.
Clinical presentation can be variable and symptoms may arise from 2 to 8 weeks after initiating the offending drug. Typical cli...
The ductus arteriosum (or arteriosus) is the thick short conduit for blood to bypass the non-ventilated lungs in the fetus. It is located between and connects the proximal left pulmonary artery and the undersurface of the aortic arch distal to the origin of the last branch of the arch, at the ao...
Aortic ductus diverticulum is a developmental outpouching of the thoracic aorta which may be mistaken for an acute aortic injury.
It is usually seen at the anteromedial aspect of the aorta at site of the aortic isthmus, where the ligamentum arteriosum attaches. It is also the sit...
Dynamic tracheal collapse refers to collapse of the trachea during expiration. It is perhaps best assessed on CT in the end expiratory phase. An inspiratory series is also useful for comparative purposes. The term excessive dynamic airway collapse (EDAC) refers to abnormal and exaggerated bulgin...
Dysphagia refers to subjective awareness of difficulty or obstruction during swallowing. It is a relatively common and increasingly prevalent clinical problem. Odynophagia is the medial term for painful swallowing.
Fluoroscopy is the mainstay of imaging assessment but manometry can help evaluat...
Dysphagia lusoria is an impairment of swallowing due to compression from an aberrant right subclavian artery (arteria lusoria).
Most patients with aberrant right subclavian arteries do not have symptoms. Some present with mild dysphagia, while a small minority have a seve...
Echogenic fetal lung lesions on antenatal ultrasound can be detected in a number of situations. They include:
Airway obstructions: lung are often enlarged and echogenic bilaterally
congenital high airways obstruction syndrome (CHAOS)
congenital tracheal stenosis
Helpful mnemonics to remember the major causes of eggshell calcification of the nodes in the thorax and mediastinum are:
A Silly Cool Sergeant Likes His Tubercular Blast
Sara Samy Likes Her Smart ABC Mnemonic
A Silly Cool Sergeant Likes His Tubercular Blast
Eggshell calcification refers to fine calcification seen at the periphery of a mass and usually relates to lymph node calcification. For similar appearance in the breast see eggshell calcification (breast).
In 1967 Jacobsen and Felson published criteria to help "avoid over-reading of the incide...
Ehlers-Danlos syndrome comprises a heterogeneous group of collagen disorders (hereditary connective tissue disease).
There is a recognized male predominance.
Clinically manifests by skin hyperelasticity and fragility, joint hypermobility and blood vessel fr...
Eisenmenger syndrome is a complication of an uncorrected high-flow, high-pressure congenital heart anomaly leading to chronic pulmonary arterial hypertension and shunt reversal.
In general, the shunts that lead to Eisenmenger syndrome share are high pressure and high flow 3. As su...
Elastofibroma dorsi is a benign soft-tissue tumor with a characteristic location and imaging appearance.
It is more frequently seen in older women, with a reported female predilection of 5-13:1. The estimated mean age at diagnosis is around 65-70 years.
An elephant trunk repair is a type of open repair procedure devised to address combined aneurysms, it is often a two staged procedure wherein the arch repair is facilitated by sternotomy and a second staged procedure is performed via left thoracotomy for the descending or thoracoabdominal aorta...
Elevated diaphragm refers to the symmetrical elevation of both domes of the diaphragm.
There is some overlap with causes of an elevated hemidiaphragm.
poor inspiratory effort
Elevated hemidiaphragms can result from many causes:
above the diaphragm 1
decreased lung volume
phrenic nerve palsy
contralateral stroke: usually middle cerebral artery distribut...
The atypical 11th rib is one of two floating ribs.
The 11th rib has a single facet on its head for articulation with the T11 vertebra. It has a short neck and no tubercle. The angle is slight. Its costal groove is shallow. The internal surface of this rib faces slightl...
Eloesser flap is a single stage procedure for the treatment of severe pleural empyema, and involves a U-shaped incision and the resection of a number of subjacent posterolateral ribs. The U-shaped flap is then folded into the pleural space creating a permanent communication.
Unlike the Clagett...
Empyemas are purulent inflammatory collections within a body cavity. They are similar to abscesses, which arise within parenchymal tissue rather than occupying a pre-existing anatomical space.
Colloquially, the term empyema is used to refer to thoracic empyemas but there are variou...
Empyema necessitans (also sometimes spelled as empyema necessitasis) refers to extension of a pleural infection out of the thorax and into the neighboring chest wall and surrounding soft tissues, e.g. extension of an empyema outwith the pleural cavity.
It may either occur due the vir...
An empyema can resemble a pleural effusion and can mimic a peripheral pulmonary abscess, although a number of features usually enable distinction between the two (see empyema vs. lung abscess). Features that help distinguish a pleural effusion from an empyema include:
Shape and location
Distinguishing between an empyema and a peripherally located pulmonary abscess is essential.
Lung abscesses are usually managed with prolonged antibiotics and physiotherapy with postural drainage whereas an empyema usually requires percutaneous or surgical drainage.
An endobronchial hemangioma is a rare benign lesion which can occur in the tracheobronchial tree.
Patients may present with hemoptysis and cough.
Maybe be occult on chest radiographs. On CT usually seen as circumscribed lesions protruding into the l...
Endobronchial intubation is the not infrequent finding of the endotracheal tube located in a bronchus and is a trivial diagnosis to make in most instances provided an adequately penetrated chest radiograph is obtained. The incidence of endobronchial intubation is greatest following emergency int...
Endobronchial lipomas are rare benign lesions arising from the adipose tissue in the submucosal layer of the bronchial wall.
Rare benign tumor with a possible male predilection.
Presenting symptoms include a cough, sputum, hemoptysis and dyspnea; however, ...
Endobronchial metastases are an uncommon form of intrathoracic metastases. They are much less common than intrapulmonary metastases.
The clinical presentation varies and includes:
post-obstructive pneumonitis from distal obstruction
Primary neoplasms which may result in endobronchial metastases may be memorized by utilizing the following mnemonic:
Kiss My RBC 1
K: Kaposi sarcoma
R: renal cell carcinoma
B: breast cancer
C: colorectal carcinoma, cervical carcinoma, carcinoid
Endobronchial valves are one-way valves that restrict airflow to a particular lung segment. The devices are inserted via bronchoscopy. They permit the drainage of airway secretions during the expiratory phase but restrict incoming airflow during inspiration 1.
They were originally designed as a...
Endogenous lipoid pneumonia, also known as idiopathic lipoid pneumonia, is of the of the two types of lipoid pneumonias. It is also sometimes known as “cholesterol pneumonia” or “golden pneumonia”
Please refer to the main article for a broad discussion, including clinical presentation, radiogra...
Enlargement of the cardiac silhouette on a frontal (or PA) chest x-ray can be due to a number of causes 1:
cardiomegaly (most common cause by far)
anterior mediastinal mass
prominent epicardial fat pad
AP projection (from supine radiographs taken ...
Eosinophilic granulomatosis with polyangiitis (EGPA), previously known as the Churg-Strauss syndrome (CSS), refers to a small to medium vessel necrotizing pulmonary vasculitis. It is also classified under the spectrum of eosinophilic lung disease and as a type of pulmonary angiitis and granuloma...
Eosinophilic lung diseases are a heterogenous group of disorders that are characterized by excess infiltration of eosinophils within the lung interstitium and alveoli and are broadly divided into three main groups 1:
idiopathic: unknown causes
secondary: known causes
eosinophilic vasculitis: ...
The eparterial bronchus is a synonymous term for the right superior lobar bronchus. Its name is derived from the bronchus being the only one originating superior to the level of the pulmonary artery. Conversely, all other bronchi can be referred to by their anatomical relationship to the pulmona...