Endometrial stromal tumours (EST) are an uncommon group of tumours arising from endometrial stromal cells. It accounts for <2% of all uterine malignancies and 10% of all uterine sarcomas.
Half occur in premenopausal women, with most patients presenting in the 5th decade.
Endometrial thickness is a commonly measured parameter on routine gynaecological ultrasound and MR imaging. The appearance, as well as the thickness of the endometrium, will depend on whether the patient is of reproductive age or post-menopausal and, if of reproductive age, at what point in the ...
Endometrioid carcinoma of the endometrium is the most common histological subtype of endometrial carcinoma accounts for 85-90% of cases. It is considered a type I carcinoma of the uterus with slow progression and relatively good prognosis. Patients are usually 55 to 65 years old.
Endometrioid carcinoma of the cervix is a rare histological sub type of cervical cancer. It falls under the sub group of adenocarcinoma of the cervix.
This sub type is thought to account for approximately 7% of cervical adenocarcinomas 2-3. The incidence of this sub type is thoug...
Endometrioid carcinomas of the ovary are a sub-type of epithelial ovarian tumours. The vast majority are malignant and invasive. On imaging, they are usually characterised as complex nonspecific solid-cystic masses and found associated with endometriosis.
Endometrioid carcinomas ...
Endometriomas, also known as chocolate cysts or endometriotic cysts, are a localised form of endometriosis and are usually within the ovary. They are readily diagnosed on ultrasound, with most demonstrating classical radiographic features.
These occur women of reproductive age.
Endometriosis is a common and clinically important problem in women of childbearing age. It is classically defined as the presence of functional endometrial glands and stroma outside the uterine cavity and its musculature 1. This is distinct from adenomyosis, in which endometrial tissue is confi...
Endometriosis affecting the canal of Nuck is an extremely rare site for endometriosis. It is proposed that retrograde implantation of endometrial tissue into patent canal of Nuck could give rise to the condition.
The condition is presented as a painful inguinal swelling. ...
Endometritis refers to inflammation or infection involving the endometrium. Endometritis can be acute or chronic and may arise in an obstetric setting, such as following delivery or miscarriage, or in a nonobstetric setting due to pelvic inflammatory disease (PID) or endometrial instrumentation....
Ovarian epithelial tumours account for the majority of all ovarian tumours (60-70%) and their malignant forms represent >90% of ovarian cancers 1. They can range from being benign to highly malignant.
There is a difference in frequency of ovarian tumour subtypes depending on menop...
An epithelioid trophoblastic tumour (ETT) is an extremely rare form of trophoblastic neoplasm. It is considered as a rare sub type of gestational trophoblastic disease 2,4.
It typically presents in women of reproductive age (peak age in late 30's) and can occur between 1 and 18 y...
Extra-uterine pelvic leiomyomas are much rarer than the typical uterine leiomyomas.
Entities that are described in this group include
cervical leiomyoma: sometimes classified as part of uterine leiomyomas
vaginal leiomyoma: extremely rare
benign metastasising leiomyoma in the pelvis
Fallopian tube rupture is most often a complication of a tubal ectopic pregnancy where the pregnancy breaks open due to progressive growth. It can potentially lead to shock.
Factors that raise the risk for a tubal rupture in a given tubal ectopic pregnancy include 2-4:
A Fallopian tube polyp refers to a small focal lesion of ectopic endometrial tissue located at the intramural portion of the fallopian tube.
The reported incidence is 1- 2.5% on hysterosalpingograms performed for assessment of infertility 3
Most patients w...
Fallopian tube spasm is a transient functional anomaly that can mimic a true mechanical tubal occlusion. At radiography, tubal spasm cannot be distinguished from a tubal occlusion. Administration of spasmolytic agents such as Glucagon can occasionally result in uterine muscle relaxation and cons...
Fallopian tube torsion is a type of adnexal torsion and usually occurs in association with an ovarian torsion (when it is then termed a tubo-ovarian torsion). An isolated fallopian tube torsion is rare but can occur.
An isolated tubal torsion can occur as a late complication of tuba...
Fanconi anaemia (FA) is a rare disorder characterised by progressive bone marrow failure, various congenital abnormalities, and predisposition to malignancies (often acute myeloid leukaemia). It is considered the commonest type of inherited marrow failure syndrome 7.
Female infertility is common, and can be due to a number of factors. Radiology often plays a key part of the work-up.
Often more than one factor (including male infertility) is the cause of infertility, some of the common causes are listed below 1-3:
age > 35 years
Female pseudohermaphroditism (FPH) is a form of disorder of gender development.
Patients with female pseudohermaphroditism have female internal genitalia and female karyotype (XX) with various degree of external genitalia virilization.
congenital adrenal hyperplasia (CAH) ...
The female reproductive system (or tract) comprises of the vagina, uterus, uterine tubes and ovaries.
It can be imaged using almost the entire range of modalities but ultrasound and MRI are most useful.
The FIGO staging systems are determined by the International Federation of Gynecology and Obstetrics (Fédération Internationale de Gynécologie et d’Obstétrique).
In general, there are five stages:
stage 0: carcinoma in situ (common in cervical, vaginal, and vulval cancer)
stage I: confined to...
A fimbrial ectopic pregnancy is a sub type of tubal ectopic pregnancy. This sub type accounts for ~ 5 -11% 1,3 of all tubal ectopic pregnancies. In a fimbrial ectopic, the implantation is at the fimbria of the fallopian tube which is closest to the ovary. The chance of a tubal rupture is compara...
Fitz-Hugh-Curtis syndrome (FHCS) refers to the development of a perihepatitis in association with pelvic inflammatory disease (PID).
The prevalence in adults with mild to moderate PID (gonorrhoic) may approximate 4% 10. The prevalence may be higher in genital tuberculosis 12. It ...
Focal adenomyosis is a morphological sub type of uterine adenomyosis. Some authors regard this term synonymous with an adenomyoma.
It is considered less common than diffuse uterine adenomyosis 4.
May be seen as a focal area of myometrical...
Follicular monitoring or follicular study is a vital component of in-vitro fertilization (IVF) assessment and timing. It basically employs a simple technique for assessing ovarian follicles at regular intervals and documenting the pathway to ovulation.
Journey to ovulation begins d...
Fowler syndrome is a rare condition characterised by
brain stem and basal ganglion calcification
glomeruloid (proliferative) vasculopathy of cerebral vessels
fetal akinesia deformation sequence with muscular hypoplasia
Sometimes a separate condition resulting in urinary re...
Frontal bossing is a calvarial radiographic feature where the front of the skull appears protruding anteriorly. It is best appreciated on a sagittal or lateral image.
This feature can be seen in many conditions (in alphabetical order):
Frontonasal dysplasia is a rare disorder involving the face and often the central nervous system:
median cleft lip
absence of the nasal tip
central nervous system
cranium bifidum occultum
agenesis of the corpus callosum
Fryns syndrome (FS) is a rare congenital disorder which can have significant phenotypic variability but is primarily characterised by cranio-facial anomalies, diarphagmatic defects and distal limb anomalies.
Incidence is estimated at 1:15,000 live births.
A functional ovarian cyst is a term given to a group of non neoplastic type of ovarian cysts. A large proportion of ovarian cysts detected on imaging are functional ovarian cysts. Entities that fall under this group include
ovarian follicular cysts
corpus luteum cysts
theca lutein cysts
Cervical funneling is a sign of cervical incompetence and represents the dilatation of the internal part of the cervical canal and reduction of the cervical length.
Greater than 50% funneling before 25 weeks is associated with approximately 80% risk of preterm delivery.
Gartner duct cysts develop from embryologic remnants of the Wolffian (mesonephric) duct. They are often noticed incidentally on ultrasound or MRI.
They may cause mass effect on adjacent structures.
Gartner duct cysts are located in the anterolateral ...
Germ cell tumours are found widely throughout the body, and encompass a wide range of individual tumours.
This article does not deal with any specific body locations. For detailed discussion please refer the articles listed at the end of this page.
Germ cell tumours arise from ecto...
A mnemonic for differential diagnosis for germ cell tumours is:
E: embryonal cell carcinoma
E: endodermal sinus tumour (yolk sac tumour)
Germ cells tumours of the ovary account for approximately 15-20% of all ovarian tumours. In children and adolescents, up to 60% of ovarian tumours can be of germ cell origin.
ovarian teratoma(s): commonest primary benign tumour of ovary and commonest germ cell tumour:
The term germinoma usually refers to a tumour of the brain (WHO Classification of CNS tumours), but can also refer to similar tumours of the ovary and testis.
dysgerminoma of the ovary
seminoma of the testis
All three tumours share similar histology.
Gestational choriocarcinoma (GC) is a type of choriocarcinoma that follows a gestational event. Similar to choriocarcinomas in general, it lies at the malignant end of the spectrum of gestational trophoblastic disease.
Approximately 50% of gestational choriocarcinomas arise from a pr...
Gestational trophoblastic disease (GTD) results from the abnormal proliferation of trophoblastic tissue and encompasses a wide spectrum of diseases, including:
invasive mole ~10%
choriocarcinoma (gestational choriocarcinoma) ~1%
placental site t...
The gonadal arteries are the paired primary vascular supply to the ovaries in the female and the testes in the male. As the anatomy of the gonadal arteries differs substantially between the sexes, they are covered separately:
Gonadal dysgenesis refers to a spectrum of anomalies with abnormal development of the gonads. It falls under the even broader group of disorders of gender development.
In many cases the gonads are replaced by fibrous tissue.
complete gonadal dysgenesis (CGD) / Swyer syndro...
Goodman syndrome is a type of acrocephalopolysyndactyly (often considered type IV). It is an extremely rare genetic disorder characterized by marked malformations of the head and face, abnormalities of the hands and feet, and congenital heart disease. The syndrome is inherited as an autosomal re...
Granulosa cell tumours of the ovary are a type of sex cord / stromal ovarian tumour.
Sex cord-stromal tumours represent approximately 8% of all ovarian tumours and are believed to arise from and/or to contain combinations of the sex cord and stromal components of the developing go...
The Greig cephalopolysyndactyly syndrome (GCPS) is a rare a pleiotropic, multiple congenital anomaly syndrome.
It is primarily characterized by:
pre-axial polydactyly (most common 2) or
mixed pre- and post-axial polydactyly
true ocular hypertelorism
The clinical history will nearly always lead to a short differential or the answer. Show off to the examiner that you have a structured approach to reporting and managing the patient.
uterus: size, version and shape (normal or variant which you should elaborate on and say w...
The gynaecology curriculum is one of our curriculum articles and aims to be a collection of articles that represent the core gynaecological knowledge.
Topics pertaining to the ovaries, uterus, vagina and associated stuctures, but excluding those specific to obstetrics and urinary sy...
A habitual miscarriage is the term given when a woman has had more than 3 miscarriages and it affects approximately 1-2% of women.
Many causes are identified.
mullerian duct anomalies
acquired uterine causes
uterine adhesion bands
Haematocolpos is a term given to a blood-filled dilated vagina due to menstrual blood in the setting of an anatomical obstruction, usually an imperforate hymen. In this condition, there is no distention of the uterine cavity, c.f. haematometrocolpos.
Patients may present...
A haematometrium refers to a uterus filled with blood.
pyometrium: uterus filled with pus
haematometrocolpos: uterus and vagina filled with blood
hydrometrium: uterus filled with fluid
Haematometrocolpos refers to a blood-filled distended uterus and vagina usually due to an anatomical mechanical obstruction precluding the evacuation of the menstrual blood.
The estimated incidence in teenagers is at ~1 in 1000-2000 5.
imperforate hymen: in ~2...
A haematosalpinx refers to intraluminal blood within the Fallopian tube (often dilated).
tubal ectopic pregnancy: common cause 1
endometriosis: common cause 5
pelvic inflammatory disease
fallopian tube torsion
Haemorrhagic corpus luteal cysts result from bleeding into corpus luteal cysts.
Commonly described findings include
complex adnexal mass
adnexal thick walled cystic lesion with lace like strands
adnexal thick walled cystic lesion with low-level echoes withi...
Haemorrhagic ovarian cysts (HOCs) usually result from haemorrhage into a corpus luteum or other functional cyst. Radiographic features are variable depending on the age of the haemorrhage. They typically resolve within eight weeks.
Patients may present with sudden-onset ...
HELLP syndrome is a pregnancy-related condition and is an abbreviation for:
elevated liver enzymes and
It is considered a severe and life threatening form of pre-eclampsia although it can occur without co-existing pre-eclampsia.
The estimated inciden...
Hemimegalencephaly is a rare congenital disorder of cortical formation with hamartomatous overgrowth all or a part of a cerebral hemisphere. This results from either increased proliferation or decreased apoptosis (or both) of developing neurons 2.
Hemimegalencephaly is a cryptogen...
Hereditary breast and ovarian cancer (HBOC) syndrome is caused by mutation to either BRCA1 or BRCA2 genes. These patients have an increased risk of breast cancer, ovarian cancer, pancreatic cancer and prostate cancer. However, these gene mutations are not the only cause of hereditary breast canc...
Herlyn-Werner-Wunderlich (HWW) syndrome, is a rare anomaly characterised by Müllerian duct anomalies (MDA) associated with mesonephric duct anomalies 3. This entity is also known as obstructed hemivagina and ipsilateral renal anomaly (OHVIRA). It is not to be confused with the Wunderlich syndro...
A heterogeneous myometrial echotexture on ultrasound can be non specific finding although it has been described with uterine adenomyosis.
Human epididymis protein 4 (HE4) is an emerging serum biomarker in the assessment of epithelial ovarian tumours. HE4 is a member of the whey associated protein (WAP) gene cluster and has uncertain biological function 1.
Early results indicate that HE4 has higher sensitivity and sensitivity than...
Hyaline degeneration is the most common form of degeneration that can occur in a uterine leiomyoma.
It is thought to occur in up to 60% of uterine leiomyomas 3.
As with many other types of degeneration, it happens when fibroids outgrow their blood supply 4. Hyaline de...
Hydatidiform moles are one of the most common but benign forms of gestational trophoblastic disease.
It is a common complication of gestation, estimated to occur in one of every 1,000-2,000 pregnancies 3. These moles can occur in a pregnant woman of any age, but the rate of occur...
Hydrocolpos is characterised by an expanded fluid filled vaginal cavity. When it is associated with distention of the uterine cavity, the term hydrometrocolpos should then be used. It may present in infancy with a lower abdominal mass, or be delayed till menarche.
Hydrolethalus syndrome is a rare lethal genetic syndrome characterised by multiple developmental defects of fetus which include
cleft lip + / - palate
agenesis of the corpus callosum
absent midline stru...
Hydrometra is a descriptive term that refers to a distended uterus filled with clear, non-infected fluid.
Hydrometrocolpos is characterised by an expanded fluid filled vaginal cavity with associated distention of the uterine cavity. It may present in infancy with a lower abdominal mass, or be delayed till menarche.
imperforate hymen (most common) also involves the upper portio...
Hydropic degeneration of the placenta is a phenomenon where numerous cystic spaces are formed within the placenta which is often accompanied by placental enlargement. It can occur in a number of situations which include
simple hydropic degeneration in 1st trimester pregnancy loss - fetal demise...
Hydrosalpinx is a descriptive term and refers to a fluid filled dilatation of the fallopian tube.
Patients may be asymptomatic or may present with pelvic pain or infertility.
One or both fallopian tubes may be affected. A hydrosalpinx results from an accumula...
Hyperechoic myometrial foci are sonographic observation where the myometrium contains numerous bright echogenic foci.
They can be observed in very different situations and the clinical context is vital in their interpretation.
Recognised causes include
There are several hypertensive states that can manifest in pregnancy. They include:
gestational hypertension - pregnancy induced hypertension (PIH)
They may be commoner in young primigravid as well as older multiparous women.
A hypocoiled umbilical cord to an umbilical cord with less than normal coiling. This is normally estimated by a low umbilical cord coiling index (usually less than 0.2 2).
single umbilical artery
abnormal cord insertion(s)
non coiled umbilical cord
Hypophosphatasia refers to a rare metabolic disorder characterised by deficient serum alkaline phosphatase activity. The effects of hypophosphatasia are primarily seen in the skeletal system. The condition has marked variation in clinical expression (see subtypes).
The true incide...
Hysterosalpingogram (HSG) is a fluoroscopic examination of the uterus and the Fallopian tubes, most commonly used in the investigation of infertility or recurrent spontaneous abortions.
Infertility to assess uterine morphology and tubal patency.
Ileal atresia is a congenital abnormality where there is significant stenosis or complete absence of a portion of the ileum. There is an increased incidence in those with chromosomal abnormalities.
This article will focus on ileal atresia alone but bear in mind that some cases correspond to jej...
Immature ovarian teratomas are uncommon ovarian germ cell tumours. They differ from mature ovarian teratomas (dermoid cysts) both histologically by the presence of immature tissue, and clinically by their more malignant behaviour.
They are considerably less common than mature ovar...
An incarcerated uterus or trapped uterus describes an extremely rare situation where a retroverted or retroflexed gravid uterus fails to ascend into the abdominal cavity.
This is an uncommon presentation and is said to occur in 1 in 3000 pregnancies. Uncomplicated retroversion may...
Indium-111 OncoScint is a radiopharmaceutical used in SPECT imaging. It is a labelled monoclonal antibody that is directed against TAG-72, which is a tumour-associated antigen associated with ~95% of colorectal carcinomas and 100% of ovarian carcinomas 1,2. Background hepatic uptake limits sensi...
Infertility is common, affecting 15-20% of couples, and is defined as the inability to conceive after one year of unprotected intercourse in the fertile phase of the menstrual cycle 3. It can be due to a variety of both female and male factors, and these are discussed in separate articles:
It is important to have a systematic way of approaching a case with subfertility in the exam.
Ultrasound is the initial examination of choice. Always say that you would further assess the uterus with 3D ultrasound. You may also say that in my department we would perform a sonohysterogram or HS...
Inguinal endometriosis is an unusual extrapelvic site for endometriosis.
The estimated incidence is as around 0.07% among those having endometriosis 4. There is an increased right sided predilection (around 80-90 %of reported cases) 9.
As with endometriosis in general ...
Interstitial ectopic pregnancy (also known as an intramural) is an important type of ectopic pregnancy with higher risks of rupture and haemorrhage compared to usual tubal ectopic pregnancies.
The term interstitial pregnancy is sometimes interchangeably used with cornual pregnancy...
Intramural uterine leiomyoma is the most common type of uterine leiomyoma in terms of location. They are centred primarily within the myometrium. A large intramural uterine leiomyoma can, however, have a submucosal or subserosal component.
They are usually asymptomatic; h...
The presence of intrauterine air can sometimes be inferred by tiny internal echoes on ultrasound or foci of very low attenuation at computed tomography (CT). The term encompasses air within the uterine cavity as well as intramyometrial air.
It can arise from a number of situations
Intrauterine blood clot can result from a number of situations in gravid, non-gravid and postpartum states. It can mimic many other pathologies.
Any condition that predisposes to an intrauterine haemorrhage can potentially result in an intrauterine blood clot.
Intra-uterine contraceptive devices (IUCD) are one of the most frequently used methods of contraception throughout the world. It prevents pregnancy by:
thinnning the endometrial lining
preventing sperm motility
There are two main types of IUCDs:
Intravenous leiomyomatosis (IVLM) is characterised by the extension into venous channels of histologically benign smooth muscle tumour arising from either the wall of a vessel or from a uterine leiomyoma.
Intravenous leiomyomatosis should not be confused with benign metastasising leiomyoma, in ...
In utero bowel perforation results in a chemical peritonitis (meconium peritonitis) from peritoneal leakage of sterile meconium.
It can result from many causes which include:
in utero intestinal ischaemia
Invasive mole is a tumorous growth associated with gestation and falls under the spectrum of gestational trophoblastic disease. Due to their aggressive growth characteristics, invasive moles are considered locally invasive non-metastasising neoplasms.
An invasive mole develops in ...
The International Ovarian Tumour Analysis (IOTA) group ultrasound rules for ovarian masses are a simple set of ultrasound findings that classify ovarian masses into benign, malignant or inconclusive masses. These rules apply to masses that are not a classical ovarian mass (e.g. corpus luteum, en...
An irregular yolk sac or an abnormally shaped yolk sac is an imaging feature that can be observed in early pregnancy scanning. It may be seen in up to 17% of early pregnancy scans 1. In contrast to an irregular gestational sac, the observation of an irregular yolk sac in not thought to correlate...
An isolated cleft palate is a type of facial cleft. This is a much rarer occurrence than a cleft lip +/- palate and is thought to represent a different pathological entity.
The estimated incidence is at ~1 per 2000-2500 pregnancies 4-5. There may be a slight female predilection 4....
An isthmic ectopic pregnancy is a sub type of tubal ectopic pregnancy an accounts for ~ 12% of such cases. According to one study the rate of tubal wall disruption was higher than with an ampullary ectopic pregnancy, suggesting that in an isthmic ectopic pregnancy, the trophoblast penetrates the...
IUCD related uterine perforations are one of the causes of uterine perforation. It is rare, but a serious complication of an IUCD insertion, and is often clinically silent.
The incidence rate is reported at ~2 in 1000 2.
Perforation at the time of insertio...
Juberg-Hayward syndrome (JHS), also known as the oro-cranio-digital syndrome, is a rare autosomal recessive syndrome characterised by the association of the following:
cleft lip and palate
minor vertebral and rib anomalies 4
horseshoe kidneys 4
Junctional zone is a region representing the inner myometrium and is a very important imaging feature in pelvic MR imaging for interpretation of various pathologies. In its intact state, it is usually visualised as a low T2 signal layer beneath the endometrium.
This low signal intensity is thou...