VACTERL is an acronym that describes a non-random constellation of congenital anomalies. It is not a true syndrome as such and is equivalent to the VATER anomaly.
The estimated incidence is 1 in 10,000-40,000 births 3.
The acronym VACTERL derives from:
V: vertebral an...
The VACTERL-H association is a rare non-random association which bears the features of the standard VACTERL association with added fetal hydrocephalus.
Unlike the standard VACTERL association which is sporadic, the VACTERL-H is hereditary with both X-linked 3 and autosomal recessive 2 inheritan...
The vagina is a midline fibromuscular tubular organ positioned in the female perineum extending superiorly from the vulva, to the cervix and uterus in the pelvis.
The vagina is 8-10 cm in length, extending posterosuperior from the vestibule through the urogenital diaphragm to th...
There can be several variations with cord insertion into the placenta:
central insertion (~90%): normal situation
eccentric cord insertion: lateral insertion of the umbilical cord >2 cm from the placental margin
term sometimes used synonymously with marginal cord insertion
marginal cord inse...
There can be many variations in the fetal presentation which is determined by which part of the fetus is projecting towards the internal cervical os. This includes:
cephalic presentation: fetal head presenting towards the internal cervical os, considered normal and occurs in the vast majority o...
There can be several variations in placental morphology. These include:
single lobed discoid placenta (single disc): most common scenario
bilobed placenta: two near equal size lobes
succenturiate lobe(s): one of more smaller accessory lobes
circumvallate placenta: rolled placental edges with...
Vasa previa refers to a situation where there are aberrant fetal vessels crossing over or in close proximity to the internal cervical os, ahead of the fetal presenting part. These vessels are within the amniotic membranes, without the support of the placenta. Vasa previa is a rare but potentiall...
Vein of Galen aneurysmal malformations (VGAMs), probably better termed as median prosencephalic arteriovenous fistulas, are uncommon intracranial anomalies that tend to present dramatically during early childhood with features of a left-to-right shunt and high-output cardiac failure.
Velamentous cord insertion is a type of abnormal umbilical cord insertion into the placenta.
The estimated incidence is ~1% in singleton and 9-15% in twin pregnancies, respectively 11. It is also more common in placenta previa than in normally located placentas. The prevalence may...
The term venous lakes may refer to:
cutaneous venous lakes, often occurring on the lower lip 1
osseous venous lakes occurring in the skull 2
placental (venous) lakes 3
Ventricular septal defects (VSD) represent defects in the interventricular septum that allow a hemodynamic communication between the right and left ventricles. It typically results in a left-to-right shunt.
They represent one of the most common congenital cardiac anomalies and may...
Evaluation of vermian lobulation is essential in assessment of the vermian maturity. MRI is a useful tool in assessment of the fetal posterior fossa.
Normal vermian lobulation by weeks 1:
by 21 weeks: the prepyramidal fissure can be seen between the tuber and pyramis
Radiological evaluation of the posterior fossa is an essential part of the routine fetal assessment, including vermian maturity assessment.
Ultrasonography is a readily available diagnostic tool in the assessment of the fetal posterior fossa but is sometimes limited due t...
Vitamin B9 (folate or folic acid) is a water-soluble vitamin, part of the vitamin B complex, vital for the synthesis of several amino acids, the purines adenosine and guanine and the pyrimidine thymine (three of the four nucleotide bases and hence critical for the synthesis of nucleic acids).
Walker-Warburg syndrome (WWS), sometimes known as HARDE syndrome, is an extremely rare lethal form of congenital muscular dystrophy. It is primarily characterized by:
fetal hydrocephalus: almost always present
neuronal migrational anomalies: agyria (cobblestone lissencephaly / lissencephaly ty...
Wharton jelly refers to the gelatinous substance within the umbilical cord.
Wharton jelly is derived from extra-embryonic mesoderm and is largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulphate) while containing smaller amounts of fibroblasts and macropha...
Wolf-Hirschhorn syndrome (WHS) is an extremely rare chromosomal anomaly characterized by partial deletion of the p arm of chromosome 4 (4p16.3).
There is a large clinical spectrum:
agenesis of the corpus callosum
Yolk sac is the first anatomical structure identified within the gestational sac. It plays a critical role in embryonal development by providing nutrients, serving as the site of initial hematopoiesis, providing endocrine, metabolic and immunological functions and contributing to the development...
Zika virus infection is a zoonosis which is associated with congenital birth defects, with microcephaly the most widely known.
Zika was once isolated to Africa and Asia, however, it spread to the Americas in the last decade 1. There were thousands of cases confirmed in the America...