Thoracic manifestations of systemic lupus erythematosus can be variable.
For a general discussion, and for links to other system specific manifestations, please refer to the article on systemic lupus erythematosus.
pleuritis: considered one of the c...
There are many types of talar dislocation given its multiple articulations:
total talar dislocation
Talar fractures are an uncommon injury, accounting for <5% of all foot fractures. Recognition of the unique talar anatomy is important for correct diagnosis.
talar head fractures
talar neck fractures
talar body fractures
talar dome osteochondral fracture
Tauopathies are a heterogeneous group of neurodegenerative diseases characterised by abnormal metabolism of tau proteins leading to intracellular accumulation and formation of neurofibrillary tangles (NFT). These neurofibrillary tangles are deposited in the cytosol of neurons and glial cells.
Telecanthus represents increased intercanthal distance. It is often used interchangeably with hypertelorism, referring to increased distance between the eyes.
Causes and associations
trauma: naso-orbito-ethmoidal (NOE) fractures
sinus and orbital tumours
Destructive lesions of the temporal bone (petrous pyramid, middle ear and antrum) have a relatively broad differential including 1:
lesions affecting petrous pyramid
neuroma of trigeminal and facial nerve
glomus jugulare tumour
Temporomandibular joint (TMJ) effusions are unusual in asymptomatic patients, and thus should trigger a careful search for underlying pathology. It usually precedes osteoarthritis of the TMJ. Effusions are seen in:
rheumatoid arthritis (RA)
Tension pneumothoraces occur when intrapleural air accumulates progressively in such a way as to exert positive pressure on mediastinal and intrathoracic structures. It is a life-threatening occurrence requiring both rapid recognition and prompt treatment to avoid a cardiorespiratory arrest.
The differential diagnosis for a terminal ileitis is quite extensive, and includes:
inflammatory bowel disease
Crohn disease (most common)
backwash ileitis due to ulcerative colitis
There is only a short list of terminal tuft masses, which can arise from the adjacent soft tissues and erode the terminal tuft as well as arising from the terminal tuft itself:
epidermal inclusion cyst: history of penetrating trauma
tenosynovial giant cell tumour: occur laterally
The terminal zones of myelination are located at the posterior aspect of the lateral ventricles (the peritrigonal regions) and are the only part of the cerebral white matter that may exhibit high T2 signal in a normal brain at 2 years of age, when myelination of cerebral white matter normally be...
Testicular cancers are the most common neoplasm in men between the ages of 20 and 34 years.
Testicular cancer is uncommon, accounting for less than 1% of all internal organ malignancies 2.
The demographics of affected individuals depends on the age of the histology of the tumour....
Testicular microlithiasis (TM) is a relatively common condition that represents the deposition of multiple tiny calcifications throughout both testes.
The most common criterion for diagnosis is that of five microcalcifications in one testicle, although definitions have varied in the past. In t...
Testicular trauma is the third most-common cause of acute scrotal pain and may result in various degree of damage to the testes.
Testicular rupture and testicular ischaemia/infarct are two severe complications which need to be ruled out. Other injuries that can occur include 1:
The four "Ds" of radiology reporting are the basic sequential tasks that a radiologist performs when reporting/reading a case, whether it be in training, the exam environment or in day-to-day clinical practice.
The 4 "Ds"
Diagnosis or differential diagnoses
There are a number of causes and mimics of thoracic aortic dilatation.
post-stenotic dilatation, e.g. bicuspid aortic valve
thoracic aortic aneurysm
atherosclerosis (usually descending thoracic aorta)
The differential for thoracic aortic stenosis includes:
aortitis (especially Takayasu arteritis)
Williams syndrome: supravalvular aortic stenosis
congenital rubella syndrome: supravalvular aortic stenosis
Thoracoliths are rare, calcified pleural-based nodules that are almost always incidental findings. They are usually considered mobile, and more common on the left.
The exact aetiology is unknown and theories include 1,2:
calcified fibrin body
degenerated pleural lipoma
Threatened miscarriage (or threatened abortion) is mainly a clinical term, used when a pregnant woman in first 20 weeks of gestation presents with spotting, mild abdominal pain and contractions, with a closed cervical os.
It occurs in 20-25% of pregnancies and is associated with ...
A number of inflammatory conditions can affect the thyroid gland, which are commonly described as thyroiditides:
acute suppurative thyroiditis (AST)
subacute lymphocytic thyroiditis: silent thyroiditis or painless subacute thyroiditis
Thyroid malignancies are most commonly primary thyroid cancers but can rarely be metastatic deposits.
Thyroid malignancies can be categorised into the following key subtypes:
primary thyroid cancers
papillary thyroid carcinoma: 60-80% of carcinomas
Tibiotalar slant is the superolateral inclination of the tibial plafond, and results in an ankle valgus deformity. There are a number of causes 1:
trauma, i.e. distal tibial fractures
osteomyelitis and/or septic arthritis
juvenile idiopathic arthritis
sickle cell dis...
Tonsillar herniation is a type of cerebral herniation characterised by the inferior descent of the cerebellar tonsils below the foramen magnum.
The terminology of caudally displaced tonsils is discussed in the article on cerebellar tonsillar ectopia.
It is a secondary sign of signif...
Tonsillitis refers to inflammation of any of the tonsils and is one of the most common head and neck infections in adolescents and young adults.
Patients may present with a variety of symptoms including painful throat (may be unilateral), dysphagia, fevers, tender cervica...
Torticollis (wryneck) is a clinical finding of head tilt with or without rotational spinal malalignment. It is not a diagnosis in itself and there are a wide range of underlying conditions. It is most common in the paediatric age group.
Torticollis can be acute (<1 week) or chronic ...
Total hip arthroplasty (THA) or total hip replacement (THR) is an orthopaedic procedure which involves the surgical excision of the femoral head and cartilage of the acetabulum and replacement of the joint with articulating femoral and acetabular components. It is a commonly performed procedure ...
Toxoplasmosis and lymphoma are frequently differential diagnoses in patients with HIV/AIDS and as treatment is substantially different distinguishing the two is important.
In many instances, the imaging appearance is classic and differentiation is not problematic; however, in 50-80% of cases, ...
Primary tracheal and endobronchial lesions are generally rare and can be either malignant or benign. The majority of these lesions are malignant.
primary malignant endobronchial lesions
squamous cell carcinoma: commonest malignant lesion in tr...
Tracheal buckling is a normal finding in young infants when it is more flexible. There is typically deviation of the trachea anteriorly and to the right (up to 90°) and any other configuration (i.e. to the left or posteriorly) should raise the possibility of underlying pathology.
The differential for tracheal masses can be rather wide.
For a single mass consider:
direct invasion from adjacent organ (lung, thyroid, oesophagus and larynx)
distant metastasis (e.g. melanoma, breast, renal and colon cancer)
squamous cell carcinoma: common...
Tracheal wall thickening may have several causes. For diagnostic purposes, tracheal thickening may be categorized by length of airway involvement in order to narrow the differential diagnoses. Note that some etiologies may be associated with either focal or diffuse pattern of involvement.
Tracheomalacia, or sometimes described as tracheobronchomalacia, is a common incidental finding on imaging of the chest of older patients and manifests as an increase in tracheal diameter as well as a tendency to collapse on expiration. Generally, more than 70% collapse of the trachea during exp...
Traction bronchiectasis refers to an aetiological sub type of bronchiectasis where there is irreversible dilatation of bronchi and bronchioles within areas of pulmonary fibrosis or distorted lung parenchymal architecture.
It can arise from a number of underlying causes which result i...
Transalar (transsphenoidal) herniation describes herniation of brain matter in and around the middle cranial fossa across the greater sphenoid wing and can be ascending or descending. Compression of structures against the sphenoid bone results in symptoms.
Transalar herniation is not...
Transependymal oedema, also known as interstitial cerebral oedema, is a type of cerebral oedema that occurs with increased pressure within the cerebral ventricles. FLAIR is the most sensitive MRI sequence for detection.
The ventricular ependymal lining is eventually disrupted, allowi...
Transient hepatic attenuation differences (THAD) lesions refer to areas of parenchymal enhancement visible during the hepatic artery phase on helical CT. They are thought to be a physiological phenomenon caused by the dual hepatic blood supply. Occasionally they may be associated with hepatic tu...
Transtentorial herniation is a type of cerebral herniation. There are two types:
descending transtentorial herniation, more frequently known as uncal herniation
ascending transtentorial herniation, which is less common than uncal herniation
Trapped lung, also known as unexpandable/unexpanded lung, is a term used where there is non-expandable lung after fluid removal, often thoracentesis. It is similar to but not entirely synonymous with the term lung entrapment, which is a similar condition but caused by active pleural disease rath...
Trauma is a leading cause of mortality in pregnancy. Pregnancy increases the incidence and severity of abdominal trauma in females.
Trauma affects up to 7% of pregnancies, and the incidence of pregnancy in level 1 trauma patients is estimated to be ~2% 1.
Traumatic spinal cord injury can manifest as a wide variety of clinical syndromes resulting from damage to the spinal cord or its surrounding structures. It can result from minor injury if the spine is weakened from disease such as ankylosing spondylitis or if there is pre-existing spinal stenos...
Triphalangeal thumb is considered a form of pre-axial polydactyly.
Triphalangeal thumbs have an incidence of 1 in 25,000 7.
A triphalangeal thumb, as the name implies, has three phalanges instead of the usual two. There is an autosomal dominant genetic transmission 8....
Troponin is a protein of key importance in the functioning of skeletal and cardiac muscle. It forms part of the contractile mechanism, and comprises three main subunits: troponin C, troponin I, and troponin T.
Elevation of serum troponin can occur from a number of causes an...
Tuberculosis of the central nervous system can result from either haematogenous spread from distant systemic infection (e.g. pulmonary tuberculosis) or direct extension from local infection (e.g. tuberculous otomastoiditis).
Intracranial manifestations of tuberculosis are protean and can affect...
Tuberculous adrenalitis is the result of adrenal mycobacterium tuberculosis (TB) infection. Its incidence has decreased in the western world with the declining incidence of tuberculosis.
As the tuberculous infection causes destruction of the adrenal cortex, primary adrenal insufficie...
Tubulinopathy refers to a wide spectrum of cortical malformations that result from defects in genes encoding the tubulin protein that regulates neuronal migration during brain development.
Some series report a high prevalence of seizures during infancy which may the initi...
Tumours of the chest wall are varied, some of which are found most often in this region. They can be divided into benign and malignant tumours and into those which arise in the ribcage and those of soft tissue density.
Benign tumours include 1,3,4:
Tumours of the male urethra are uncommon. They can be categorised both on the grounds of histology and location.
squamous cell carcinoma of the urethra: 80%
urothelial/transitional cell carcinoma of the urethra: 15% (predominantly posterior urethra)
adenocarcinoma of the urethra: 5...
The small intestine is rarely the site of malignant tumours, although it accounts for ~75% of the entire length of the GI tract and more than 90% of the mucosal surface. Approximately 40 different histologic tumour types have been described.
In this article, an overview will be given of the mo...
Tumours that metastasise to bone may be remembered using the mnemonic "lead kettle" spelled PBKTL (lead is Pb on the Periodic Table).
For females, breast and lung are the most common primary sites; nearly 80% of cancers t...
Twin pregnancies are the most common multifetal pregnancies.
Multifetal pregnancies account for ~ 1% of all pregnancies but are seen in much higher numbers in populations where in vitro fertilisation (IVF) is a common practice, most of which are twin pregnancies.
Ulnar variance (also known as Hulten variance) refers to the relative lengths of the distal articular surfaces of the radius and ulna.
Ulnar variance may be:
neutral (both the ulnar and radial articular surfaces at the same level)
positive (ulna projects more distally)
negative (ulna projec...
Ultrasound appearance of liver metastases can have bewildering variation, and the presence of hepatic steatosis can affect the sonographic appearance of liver lesions.
Patterns do exist between ultrasound appearance of the liver metastases and the likely prima...
Umbilical cord cysts can refer to any cystic lesion associated with the umbilical cord. They can be single (commoner) or multiple.
They may be seen in ~3% of pregnancies in the first trimester 8.
Umbilical cord cysts can represent either true or false cysts:
Unilateral axillary lymphadenopathy while being more concerning than bilateral axillary lymphadenopathy can still arise from a various benign as well as malignant causes.
other regional infective causes
ipsilateral arm infection, e.g. cellulitis
Unilateral facet dislocation is a relatively stable type of facet dislocation.
Flexion/distraction associated with rotation. The inferior articular facet of vertebral above moves over the superior facet of the vertebral below and becomes locked. It usually affects C4-C5 or...
Unilateral pulmonary oedema represents only 2% of cardiogenic pulmonary oedema with predilection for the right upper lobe and is strongly associated with severe mitral regurgitation 1, 2. It is hypothesised that the regurgitation jet is directed towards the right superior pulmonary vein thus pre...
The differential diagnosis for unilateral testicular lesions is wide-ranging.
seminoma (40-50% of testicular malignancies)
non-seminomatous germ cell tumours:
testicular epidermoid (teratoma with ectodermal elements only)
An upper gastrointestinal bleed usually refers to bleeding proximal to the ligament of Treitz.
Distribution of bronchiectasis can help in narrowing the differential diagnosis. Upper lobe bronchiectasis is typically seen in:
Rarely it may be seen with non tuberculous mycobacterial infection (e.g. MAC infection 2)
When in mid-upper lobes also consid...
There are numerous causes of urinary bladder diverticula:
Primary (congenital or idiopathic)
Hutch diverticulum (in paraureteral region)
bladder outlet obstruction
bladder neck stenosis
posterior urethral valve
prostatic enlargement (hypertrophy; carcinoma)
Bladder diverticulum are outpouchings from the bladder wall, whereby mucosa herniates through the bladder wall. They may be solitary or multiple in nature and can vary considerably in size.
There are two peaks - one at 10 years and the other at 60-70 years 2.
Causes of urinary bladder wall or lumen calcification include:
schistosomiasis of the urinary tract
calculus in a urachal cyst or in a bladder divertic...
Urinary diversion is created after the removal of the urinary bladder (radical cystectomy or cystoprostatectomy, usually done to treat invasive bladder cancer).
There are three main varieties:
neobladder formed from a segment of ileum (i.e. ileal conduit, also known as a "Bricker conduit")
Uterine enlargement can occur in a number of situations from both diffuse and focal processes. These include:
gestation related events
normal intrauterine pregnancy
molar pregnancy - gestational trophoblastic disease
postpartum uterus - still larger than usual
The terms valgus and varus refer to angulation (or bowing) within the shaft of a bone or at a joint.
It is determined by the distal part being more medial or lateral than it should be. Whenever the distal part is more lateral, it is called valgus. Whenever the distal part is more medial, it is ...
The Valsalva manoeuvre is the forced expiration of air against a closed airway, resulting in increased intra-abdominal, intrathoracic and pharyngeal pressure. It can be performed against a closed glottis or by one closing the mouth and pinching the nose while forcibly exhaling.
It is commonly u...
Valvular heart diseases, or cardiac valvulopathies, describe any acquired or congenital disease affecting one or more of the four cardiac valves.
This is a general index article that classifies cardiac valvulopathies depending on which valve(s) is affected 1. See individual articles for in-dept...
Vascular pedicle is bordered on the right by venous structures (right brachiocephalic vein above and superior vena cava) and on the left by an arterial structure (the left subclavian artery origin). The azygos vein (black oval) is seen en face above the right main bronchus.
The vascular pedicle...
Vascular rings and slings refer to the congenital vascular encirclement of the oesophagus and/or trachea by anomalous/aberrant vessels.
Vascular rings are rare, occurring in <1% of patients 1. No gender or ethnic predispositions have been identified 3.
Venous thromboembolism covers a wide spectrum of diseases. Individual conditions and complicating condition include:
deep vein thrombosis (DVT)
pulmonary embolism (PE)
dural venous sinus thrombosis
Ventriculomegaly is defined as enlargement of the ventricles. Simply, there are two causes:
Refer to the article on hydrocephalus vs atrophy for more details on how to differentiate both entities.
Ventriculoperitoneal (VP) shunts are a device used to shunt cerebrospinal fluid in the treatment of hydrocephalus.
As the name suggests, a catheter is placed with its tip in the ventricle. The external portion of the catheter is connected to a valve that regulates the flow of CSF based on a pre...
The differential diagnosis for a vertebral body mass is broad and may range from a completely benign, sclerotic enostosis (bone island) to a malignant primary bone tumour.
Broadly, these lesions can be separated into:
primary bone tumours
Vertebral scalloping is a concavity to the posterior (or less commonly anterior) aspect of the vertebral body when viewed in a lateral projection. A small amount of concavity is normal, as is concavity of the anterior vertebral body (see vertebral body squaring).
Vertebra plana (a.k.a. pancake / silver dollar / coin-on-edge vertebra) is the term given when a vertebral body has lost almost its entire height anteriorly and posteriorly, representing a very advanced compression fracture. Plural is vertebrae planae. It can occur in a variety of settings, incl...
Vertical-banded gastroplasty (VBG) is an older, purely restrictive procedure used to treat morbid obesity.
It involves creating a small gastric pouch, based on the lesser curvature of the stomach (which is thicker and less resistant to stretching than the greater curvature), by using...
Very bizarre generalised lesions of bone tend to make you exclaim "Oh my! What is going here?" Although there are numerous potential causes, in this situation it is worth thinking of a number of entities:
skeletal dysplasias and metabolic diseases
The vestibular line of Lapayowker refers to a vertical line passing down the most lateral aspect of vestibular apparatus. The petrous part of internal carotid artery lies medial to this line but lies lateral to it in the case of an aberrant internal carotid artery which is the characteristic ang...
Viral encephalitides are the result of brain parenchymal infection by a number of different viruses, many of which have similar presentations and imaging features. Specific diagnosis often requires PCR.
For viral infection of the meninges, please refer to the general article on viral meningiti...
Visceral artery aneurysms are abnormal focal dilatations of arteries supplying abdominal organs. Visceral artery aneurysms include both true aneurysms and pseudoaneurysms.
Owing to different clinical manifestations and a unique, specific, pathology, renal artery aneurysms are discussed separate...
Vulval neoplasms are rare and mostly seen in an elderly female patients. Squamous cell carcinoma is most common malignancy of the vulva which only 30% of them are associated with oncogenic HPV viruses.
Squamous neoplastic lesions
classic vulvar intraepithelial neopla...
Wackenheims line (also known as the clivus canal line or basilar line) is formed by drawing a line along the clivus and extending it inferiorly to the upper cervical canal.
Normally the tip of the dens is ventral and tangential to this line. In basilar invagination odontoid process transects th...
Wartenberg syndrome also known as cheiralgia paresthetica is due to compression of superficial branch of the radial nerve in the distal forearm. It can be secondary to tight watch band or handcuffs, compression from distal radius fracture or idiopathic.
Patients present ...
Certain well-defined breast cancers tend lack the characteristic spiculation and can give false reassurance of more benign entities on both ultrasound and mammography. These include:
certain high grade invasive ductal carcinomas: not enough time for a desmoplastic reaction to form spiculation
White coat hypertension (abbreviated alternatively as WCH or WCHT), not to be confused with the white coat effect (WCE), is commonly defined as typical in-clinic blood pressure (BP) measurements of 140/90 mm Hg or more in the presence of multiple daytime out-of-clinic home or ambulatory BP readi...
White matter changes in HIV have overlapping appearances and varied in aetiology. These can be divided into:
primary effects of HIV
metabolic and nutritional disorders
Primary effects of HIV
The interpedicular (IP) distance, which is the distance measured between the pedicles on frontal/coronal imaging, can be widened in a number of situations.
conditions that can cause dural ectasia (can potentially cause widening)
Widening of the presacral space is one of the diagnostic indicators of the diseases involving pelvic pathology and rectal involvement. It is ideally measured on barium studies at the level of S3/4 disc level on lateral radiographs and the normal value of the presacral space is <15 mm in adults....
The (absent) pedicle sign, also called the winking owl sign, occurs on plain film when a pedicle is absent.
The term, winking owl sign, where the missing pedicle corresponds to the closed eye, the contralateral pedicle to the other open eye, and the spinous process to the beak of the animal on ...
Artifacts can present in a variety of ways including abnormal shadow noted on a radiograph or degraded image quality and have been produced by artificial means from hardware failure, operator error and software (post-processing) artifacts.
There are common and distinct artifacts for film, comp...