Asbestosis refers to later development of diffuse interstitial fibrosis secondary to asbestos fibre inhalation and should not be confused with other asbestos related diseases.
Asbestosis typically occurs 10-15 years following the commencement of exposure to asbestos and is dose re...
Ascending aortic aneurysms are the most common subtype of thoracic aortic aneurysms, and may be true or false injuries.
Ascending aortic aneurysms represent 60% of thoracic aortic aneurysms.
Typically ascending aortic aneurysms are an incidental finding a...
Aspergillus clavatus is one of the species of Aspergillus that can cause pathology in humans. It is allergenic and causes a hypersensitivity pneumonitis called malt-workers lung.
Asthma is a relatively common condition that is characterised by at least partially reversible inflammation of the airways and reversible airway obstruction due to airway hyper-reactivity. It can be acute, subacute or chronic.
Asthma is one of the most common chronic diseases in t...
Atrial-oesophageal fistulas are rare pathological connections between the left atrium and the oesophagus.
The presentation is non-specific. Patients may complain of fever, malaise, dysphagia or present with neurological symptoms 3.
The chief cause of atrial-...
Atypical pneumonia refers to the radiological pattern associated with patchy inflammatory changes, often confined to the pulmonary interstitium, most commonly associated with atypical bacterial aetiologies such as Mycoplasma pneumoniae, Chlamydophila pneumoniae and Legionella pneumophilia. Viral...
BALT lymphoma is an abbreviated term for bronchus-associated lymphoid tissue lymphoma. These neoplasms fall under the broader umbrella of mucosa associated lymphoid tissue (MALT) lymphomas. It is sometimes considered a type of primary pulmonary lymphoma.
Up to half of pat...
Behçet disease is a multi-systemic and chronic inflammatory vasculitis of unknown aetiology.
The mean age at which Behçet disease occurs is 20-30 years. The disease is most prevalent in the Mediterranean region, Middle East and East Asia. The highest incidence has been reported in...
Benign metastasising leiomyoma (BML) is a rare metastatic phenomenon that is observed when a pelvic leiomyoma is present.
Women who have undergone hysterectomy for leiomyomas are most commonly affected.
Patients are usually asymptomatic at presentation. A h...
Bilateral hilar lymph node enlargement can arise from many causes, which include:
lymphoma: more common in hodgkin lymphoma than non-hodgkin lymphoma.
inorganic dust disease
Bronchial anthracofibrosis has been defined as luminal bronchial narrowing associated with anthracotic pigmentation on bronchoscopy without a relevant history of pneumoconiosis or smoking.
However, there is a potential relationship between bronchial anthracofibrosis and tuberculosis (TB) 1. Co-...
Bronchial arterial aneurysm refers to any form of aneurysmal dilatation involving any segment of the bronchial artery. The term is sometimes used synonymously with a bronchial arterial pseudoaneurysm 2.
They are a rare entity and are reported in <1% of those who undergo selective ...
Bronchial carcinoid tumours are carcinoid tumours primarily occurring in relation to a bronchus. They were previously incorrectly termed as bronchial adenomas. They usually occur in association with a segmental or larger bronchus.
Typically affects patients from 3rd to 7th decades...
Bronchogenic cysts are congenital malformations of the bronchial tree (a type of bronchopulmonary foregut malformation). They can present as a mediastinal mass that may enlarge and cause local compression. It is also considered the commonest of foregut duplication cysts.
Broncholithiasis is a term given for the presence of calcified or ossified material within the lumen of the bronchus.
A broncholith is usually formed by erosion by and extrusion of a calcified adjacent lymph node into the bronchial lumen and is usually associated with long-standing f...
Bronchopneumonia, also sometimes known as lobular pneumonia, is a radiological pattern associated with suppurative peribronchiolar inflammation and subsequent patchy consolidation of one or more secondary lobules of a lung in response to bacterial pneumonia.
Pneumonia is the most...
Bronchopulmonary dysplasia (BPD) refers to late pathological lung changes that develop several weeks later in infants on prolonged ventilation.
BPD and chronic lung disease of prematurity (CLDP) have often been used interchangeably to describe the condition post-treatment of premat...
Calcifying fibrous pseudotumours (CFPT) of the lung are very rare, benign lesions of the lung.
They are composed of hyalinised collagen with psammomatous-dystrophic calcification and a typical pattern of lymphocytic inflammation.
CFPTs usually occur within soft tissues but have be...
Caplan syndrome, also known as rheumatoid pneumoconiosis, is the combination of seropositive rheumatoid arthritis and a characteristic pattern of fibrosis.
Although first described in coal miners (coal workers' pneumoconiosis), it has subsequently been found in patients with a variety of pneumo...
A capnothorax, sometimes referred to as a carbon dioxide (CO2) pneumothorax, has been reported as a potential complication with laparoscopic surgeries.
It has been reported with almost all laparoscopic surgeries and is more likely to occur with high CO2 pressures and prolonged sur...
Carcinosarcomas are highly malignant biphasic tumours with both carcinomatous (epithelial) and sarcomatous (bone, cartilage, or skeletal muscle) components.
It can arise in many organs:
lung 5: pulmonary carcinosarcoma
oesophagus 1: oesophageal carcinosarcoma
genitourinary tract ...
Castleman disease, also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia, is an uncommon benign B-cell lymphoproliferative condition. It can affect several regions of the body although commonly described as a solitary mediastinal mass.
There are two distinct subty...
Cellular non-specific interstitial pneumonia is one of the two histological subtypes of non-specific interstitial pneumonia (NSIP). It is less common compared with fibrotic NSIP but carries a much better prognosis.
Symptoms are non-specific and include insidious onset of...
Centrilobular pulmonary emphysema is the most common morphological subtype of pulmonary emphysema.
It may be found in up to one-half of adult smokers at autopsy 1.
The pathological process of centrilobular emphysema typically begins near the centre of the secondary pul...
Cervical aortic arch is a rare aortic arch anomaly characterised by an elongated, high-lying aortic arch extending at or above the level of the medial ends of the clavicles.
Patients with cervical aortic arch are usually asymptomatic. Symptomatic patients may present with...
Charcot-Leyden crystals consist of collections of bipyramidal crystalloid made up of eosinophilic membrane proteins, which occur in:
other eosinophilic lung disease 2
certain cases of sinusitis (e.g. allergic fungal sinusitis)
They may be detected in the sputum or sinus secretions wi...
Chronic bronchitis (CB) is often defined as the presence of productive cough for three months in two successive years in a patient in whom other causes of chronic cough, such as tuberculosis, lung cancer and heart failure, have been excluded. It can be an important pathological component of chro...
Chronic eosinophilic pneumonia (CEP) is a type of eosinophilic lung disease. It is an idiopathic condition and is characterised by chronic and progressive clinical features.
Most patients are middle aged, and approximately 50% have background asthma. There is a greater female pred...
Chronic pulmonary emboli are mainly a consequence of incomplete resolution of pulmonary thromboembolism.
vascular CT signs include
direct pulmonary artery signs
calcified thrombus - calcific pulmonary ...
Clear cell tumour of the lung is a rare benign pulmonary neoplasm that contains an abundant amount of glycogen. It is often classified under the spectrum of perivascular epithelioid cell tumours (PEComas).
Usually seen as a rounded, smooth-walled, and peripheral parenchym...
Coal workers' pneumoconiosis (CWP) is an occupational disease (type of pneumoconiosis) caused by exposure to coal dust free of silica (washed coal). Histologically, CWP is classified according to disease severity into simple (presence of coal macules) and complicated (with progressive massive fi...
Coccidioidomycosis refers to an infection caused by the dimorphic fungus Coccidioides spp, usually localised to the lungs. This disease is not to be confused with the similarly named paracoccidioidomycosis.
The most common forms of Coccidioides spp are Coccidioides immitis and Coc...
Combined pulmonary fibrosis and emphysema (CPFE) are a possible new addition to a growing list of smoking-related lung disease characterised by the coexistence of usual interstitial pneumonia (UIP) or nonspecific interstitial pneumonia (NSIP) with emphysema in smokers.
Common variable immunodeficiency (CVID) is a condition that is associated with an impaired immune system. It is considered the most common symptomatic primary immunodeficiency, and is characterised by recurrent respiratory tract infections.
The commonest presentation is t...
Pulmonary manifestations of common variable immunodeficiency can be variable. The respiratory system is one of the most commenly affected systems in common variable immunodeficiency.
Radiographic disease spectrum
bronchiectasis with interstitial lung disease
could either be due to ...
Complete tracheal rings are a rare, isolated tracheal or tracheobronchial anomaly resulting from abnormal cartilage growth, forming a complete ring and often causing airway stenosis.
Clinically, it manifests as respiratory distress in infants or mild symptomatic airway co...
Congenital lobar overinflation (CLO), previously called congenital lobar emphysema, is a congenital lung abnormality that results in progressive overinflation of one or more lobes of a neonate's lung.
On imaging, it classically presents on chest radiographs as a hyperlucent lung segment with o...
Congenital tracheo-oesophageal fistula is a congenital pathological communication between the trachea and oesophagus.
Tracheo-oesophageal fistula and oesophageal atresia have a combined incidence of approximately 1 in 3500 live births 1-3,5. There is only a minimal hereditary/ge...
Constrictive pericarditis (or perhaps better termed pericardial constriction) is a type of pericarditis which leads to diastolic dysfunction and potentially symptoms of right heart failure.
No single demographic is affected as there are numerous causes of constrictive pericarditi...
Crack lung is a term used to describe one of the respiratory complications of smoked crack cocaine.
Patients present with sympathetic hyperactivity such as tachycardia, hypertension, dilated pupils, and chest pain, productive cough, dyspnoea, and hypoxaemia along with fev...
Cryptococcosis is a fungal infection caused by Cryptococcus neoformans, a globally distributed fungus that is commonly found in soil, especially that containing pigeon and avian droppings. Infection is acquired by inhaling spores of fungus.
Occurs worldwide without any defined en...
Cystic hygroma, also known as cystic or nuchal lymphangioma, refers to the cystic variety of congenital lymphangioma which, most commonly, occur in the cervicofacial regions, particularly at the posterior cervical triangle.
They usually occur in the fetal/infantile and paediatri...
Cytomegalovirus (CMV) pneumonia is a type of viral pneumonitis and occurs due infection with cytomegalovirus (CMV), which is a member of the Herpetoviridae family.
CMV infection is particularly important in those who are immunocompromised (e.g. those with AIDS / allogenic bone mar...
Desquamative interstitial pneumonia (DIP) is an interstitial pneumonia closely related to, and thought to represent the end stage of respiratory bronchiolitis interstitial lung disease (RB-ILD) 1. It is associated with heavy smoking.
It is considered one of the rarest of idiopathi...
Diaphragmatic eventration refers to an abnormal contour of the diaphragmatic dome. It typically affects only a segment of the hemidiaphragm, compared to paralysis/weakness where the entire hemidiaphragm is typically affected.
Diaphragmatic eventration is congenital in nature and due...
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is an extremely rare pulmonary disorder where there is a proliferation of neuroendocrine cells within the lung. It is however recognised with increasing frequency.
There may be an increased female predilection ...
Diffuse panbronchiolitis (DPB) or Asian panbronchiolitis is an idiopathic progressive inflammatory small airway obstructive lung disease.
There is striking predilection in east Asia (e.g. Japan, Korea, China). It tends to present in middle aged (~ 30-60-year-old) adults, often non...
Dysphagia lusoria is an impairment of swallowing due to compression from an aberrant right subclavian artery (arteria lusoria).
Most patients with aberrant right subclavian arteries do not have symptoms. Some present with mild dysphagia, while a small minority have a seve...
Elastofibroma dorsi is a benign soft-tissue tumour with a characteristic location and imaging appearance.
It is more frequently seen in older women, with a reported female predilection of 5-13:1. The estimated mean age at diagnosis around 65-70 years.
Empyema necessitans (also sometimes spelt as empyema necessitasis) refers to extension of a pleural infection out of the thorax and into the neighbouring chest wall and surrounding soft tissues, e.g. extension of an empyema outwith the pleural cavity.
It may either occur due the viru...
Endogenous lipoid pneumonia, also known as idiopathic lipoid pneumonia, is of the of the two types of lipoid pneumonias. It is also sometimes known as “cholesterol pneumonia” or “golden pneumonia”
Please refer to the main article for a broad discussion, including clinical presentation, radiogra...
Epipericardial fat necrosis is a rare self-limiting cause of an acute chest pain in an otherwise healthy individuals. It occurs within the mediastinum outside the pericardium.
The patient presents with an acute chest pain that may mimic other cardiopulmonary causes. It is...
Epithelial-myoepithelial carcinoma of lung is a very rare type of lung carcinomas of the salivary gland type.
Diagnosis is based on the identification of myoepithelial cells, with spindle cells, clear cells, or plasmacytoid differentiation or a mixture of phenotypes, along with a var...
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell, non-familial multisystemic granulomatosis, with widespread manifestations and of highly variable severity. The most common presenting symptom is bone pain.
Erdheim-Chester disease is a rare, non-inherited disease of midd...
Pulmonary manifestations of Erdheim-Chester disease are uncommon.
The lungs are affected in ~25% (range 20-35%) of cases 5.
Described findings include 1
symmetric reticular interstitial opacities
smooth interlobular septal thickening and fiss...
Ewing sarcoma family of tumours (ESFT), also referred as Ewing sarcomas of the chest wall, are malignant tumours affecting children and young adults, originating either from the osseous structures or the soft tissues of the chest wall.
On imaging, they are usually characterised as a large extr...
Extrapleural haematoma (EPH) is a rare situation, which usually occurs due to rib fracture or blunt chest injury.
EPH results from accumulation of blood in the extrapleural space where the overlying extrapleural fat is displaced centrally.
common: injury to intercostal ar...
Fat embolism syndrome (FES) is a rare clinical condition caused by circulating fat emboli leading to a multisystemic dysfunction. The classical clinical triad consists of:
It occurs in ~2.5% (range 0.5-4%) of th...
Fibrothorax is defined as fibrosis within the pleural space, and occurs secondary to the inflammatory response to one of the following events:
tuberculosis / tuberculous pleuritis - particularly as a late sequelae 3
asbestos related pleural disease
Fibrotic non-specific interstitial pneumonitis is a histological subtype of non-specific interstitial pneumonitis (NSIP). It is considered the more common form 1. This pattern manifests as chronic interstitial inflammation obscured by interstitial fibrosis (with dense collagen), a temporal homog...
Flail chest or flail thoracic segment occurs when three or more contiguous ribs are fractured in two or more places. Clinically, a segment of only one or two ribs can act as a flail segment, hence there is some controversy between the clinical and radiological definitions.
Focal lymphoid hyperplasia of the lung refers to an abnormal accumulation of non-malignant lymphocytic aggregates within the lung.
It iwas previously known as pulmonary pseudolymphoma.
Clinical features can vary from being asymptomatic to various symptoms s...
Ganglioneuromas are fully differentiated neuronal tumours that do not contain immature elements and potentially occur anywhere along the peripheral autonomic ganglion sites.
On imaging, usually, they present as well-defined solid masses and can be quite large at presentation. Generally, they a...
Pulmonary graft versus host disease (GvHD) is one of the thoracic manifestations that can complicate haematopoetic stem cell transplantation. Pulmonary GvHD can be broadly divided into acute and chronic disease 1-4:
acute pulmonary GvHD
pulmonary involvement is rare
the median time of onset o...
Granulomatosis with polyangiitis (GPA), previously known as Wegener granulomatosis, is a multisystem systemic necrotising non-caseating granulomatous vasculitis affecting small to medium sized arteries, capillaries and veins, with a predilection for the respiratory system and kidneys 3.
This article discusses the pulmonary manifestations of granulomatosis with polyangiitis (previously known as Wegener's granulomatosis). It is classified as a type of pulmonary angiitis and granulomatosis.
For a general discussion of the condition, please refer to the main article on granulomato...
Granulomatous lung disease refers a broad group of infectious and well as non infections conditions characterised by formation of granulomas.
The spectrum includes
pulmonary non tuberculous mycobacterial infection
H1N1 influenza is a strain of influenza that notably resulted in a pandemic in 2009.
It is type of influenza A virus of swine origin.
There can be a wide spectrum of clinical syndromes with patient's ranging from being asymptomatic to having fulminating viral p...
Hereditary haemorrhagic telangiectasia (HHT) is also known as Osler-Weber-Rendu syndrome.
Worldwide prevalence ~1.5 per 100,000. Wide geographic variability with much higher incidence in certain regions, e.g. 1 in 200 in Dutch Antilles, 1 in 3500 in France.
Heroin induced pulmonary oedema is an aetiological subtype of non cardiogenic pulmonary oedema. It may be prevalent in up to 40% of patients admitted with a heroin overdose 2.
It is defined by some authors as a syndrome in which a patient develops significant hypoxia (room air saturation< 90% w...
Acquired immunodeficiency syndrome (AIDS) is an immunosuppressed state, caused by infection with the human immunodeficiency virus (HIV). It is characterised by opportunistic infections, neoplasms and neurological manifestations.
According to the United Nations programme on HIV/AID...
Pulmonary manifestations of Hodgkin lymphoma are relatively rare, present in 5-12% of patients at the time of diagnosis. It is relatively more common with the nodular sclerosing subtype. Pulmonary involvement usually indicates stage IV disease.
Bilateral involvement is ...
Horseshoe lung is one of the rare congenital anomalies of the lung. A band of pulmonary parenchyma is formed extending between the right and left lungs. The pulmonary tissue can be seen either anterior to the aorta or posterior to the pericardium at the caudal end.
Hyperimmunoglobulin E (hyper IgE) syndrome (HIES), also known as Job syndrome, consists of heterogeneous group of complex hereditary combined B- and T-cell immune deficiency diseases characterised by recurrent Staph aureus chest infections, characteristic coarse facial appearance and dental prob...
Idiopathic dilatation of the pulmonary trunk is a rare congenital anomaly comprising of pulmonary trunk enlargement with or without dilatation of the right and left pulmonary arteries.
For this diagnosis, exclusion of pulmonary and cardiac diseases (mainly pulmonary valve stenosis) and confirma...
Idiopathic giant bullous emphysema, also known as vanishing lung syndrome (VLS), is characterised by giant emphysematous bullae, which commonly develop in the upper lobes and occupy at least one-third of a hemithorax. It is a progressive condition that is also associated with several forms of em...
Idiopathic pulmonary fibrosis (IPF) is a clinical syndrome and considered the most common and the most lethal form of pulmonary fibrosis corresponding to the histologic and imaging pattern of UIP. It is more common in middle age or elderly men and diagnosed by:
histological or imaging pattern ...
Idiopathic pulmonary haemosiderosis (IPH) is an uncommon form of pulmonary haemosiderosis. It is characterised by the triad of
iron deficiency anemia
diffuse pulmonary infiltrates, usually represented by diffuse pulmonary haemorrhage
The diagnosis is usually made by exclusion 1.
IgG4-related lung disease is a recently described condition. It may occur with or without systemic involvement. It is considered part of the spectrum of IgG-4 related disease.
On HRCT of the chest, it may be categorised into four major subtypes 5:
solid nodular type
Incomplete double aortic arch is a rare vascular ring anomaly wherein a segment of the minor aortic arch, usually the left, is atretic.
As in the case of other vascular rings, this anomaly can cause 1:
Some patients may reach adulthood with...
Infectious bronchiolitis refers to subtype of bronchiolitis where there is an definite infective precipitant. It falls under the sub group in inflammatory bronchiolitides and by some authors is considered a type of cellular bronchiolitis 3. It tends to be more clinically severe in children than ...
Inflammatory myofibroblastic tumours (IMT), also known as plasma cell granulomas, are rare neoplasms that have a diverse spectrum of biological behaviour.
It can occur at any age and there is currently no recognised gender predilection.
Composed of spindle cells (key ...
Inflammatory myofibroblastic tumours of the lungs are a location specific type of inflammatory myofibroblastic tumours.
They are very rare with their incidence reported at approximately 0.04-1% of all the pulmonary neoplasms 1. While it can affect any age group, around 25% of case...
Intercostal lung hernia is defined as protrusion of the lung beyond the confines of the thoracic cage. It is an uncommon entity.
Hernias which are symptomatic may cause dyspnoea, chest wall pain or a visible or palpable chest bulge (most common in intercostal lung hernias...
Intercostal nerve neurilemmomas, also known as intercostal nerve schwannoma or neurinoma, are nerve sheaths encapsulated tumours affecting intercostal nerves.
Please refer to the article on schwannomas for a broad discussion about these tumours.
They account for less than 10% ...
Interstitial thickening is pathological thickening of the pulmonary interstitium and can be divided into:
interlobular septal thickening
intralobular septal thickening
secondary pulmonary lobules
Intrapulmonary lipomas are rare fat containing benign lung lesions.
They mostly occur in the adult population, with occurence in the paediatric population is extremely rare.
As with all lipomas they are composed of adipose tissue. The origin of the peripheral intrapulm...
Invasive mucinous adenocarcinoma of lung is a subtype of invasive adenocarcinoma of the lung. It was formerly known as mucinous bronchoalveolar carcinoma.
Mucinous carcinomas originate from columnar mucus-containing cells (c.f. non-mucinous tumours which arise from Clara cells or typ...
Kaposi sarcoma (KS) is a low-to-intermediate grade mesenchymal tumour that involves the lymphovascular system. The tumour can involve the pulmonary, gastrointestinal, cutaneous and musculoskeletal systems.
There are four recognised variants 1:
classic (chronic): multiple distal lowe...
Kartagener syndrome is a subset of primary ciliary dyskinesia, an autosomal recessive condition characterised by an abnormal ciliary structure or function, leading to impaired mucociliary clearance.
The prevalence of primary ciliary dyskinesia is approximately 1 in 12,000-60,000 ...
This originally French article needs further translation and merging with the existing English article on hydatid disease.
Le kyste hydatique est une affection parasitaire due au taenia granulosis, considérée comme une zoonose atteignant aussi bien l'homme que les animaux, notamment les carnivo...
Langerhans cells are dendritic cells of monocyte-macrophage lineage, containing large granules called Birbeck granules. They are normally found in epithelial surfaces, lymph nodes and other organs, and can also be found elsewhere, particularly in association with Langerhans cell histiocytosis.
Large cell carcinoma of the lung is one of the histological types of non-small cell carcinomas of the lung.
It is thought to account for approximately 10% of bronchogenic carcinoma 1.
Patient presents with dyspnea, chronic cough and haemoptysis.