Bartholin gland abscess is a complication that may result from an infected Bartholin gland cyst.
Abscesses are usually in a similar location to Bartholin gland cysts. Features of Bartholin gland abscess are otherwise similar to Bartholin gland cyst described in separate ...
Benign metastasising leiomyoma (BML) is a rare metastatic phenomenon that is observed when a pelvic leiomyoma is present.
Women who have undergone hysterectomy for leiomyomas are most commonly affected.
Patients are usually asymptomatic at presentation. A h...
Brenner tumours are an uncommon surface epithelial tumour of the ovary. It was originally known as a transitional cell tumour due to its histological similarity to the urothelium. Brenner tumours account for ~3% of ovarian epithelial neoplasms. They can very rarely occur in other locations, incl...
Serum CA-125 is well recognised as an ovarian cancer-associated marker and is an antigen determinant on a high-molecular-weight glycoprotein. The normal range of CA-125 is 0-35 U/mL.
Serum CA-125 levels can also be used to monitor the response to treatment as well as a prognostic indicator sinc...
Carcinoma of the cervix is a malignancy arising from the cervix and is considered the third most common gynaecologic malignancy (after endometrial and ovarian).
It typically presents in younger women with the average age of onset at around 45 years.
Carcinosarcomas are highly malignant biphasic tumours with both carcinomatous (epithelial) and sarcomatous (bone, cartilage, or skeletal muscle) components.
It can arise in many organs:
lung 5: pulmonary carcinosarcoma
oesophagus 1: oesophageal carcinosarcoma
genitourinary tract ...
Cesarean section scar diverticulums are a defect in the lower uterine cavity at the site of the cesarean section scar.
in a study was found to be the only finding in patients with bleeding disturbances
Choriocarcinoma is an aggressive, highly vascular tumour. When it is associated with gestation, it is often considered part of the spectrum of gestational trophoblastic disease; it is then termed gestational choriocarcinoma. When it occurs in the absence of preceding gestation, it is termed non-...
A collision tumour of the ovary is an uncommon ovarian neoplasm where there is co-existence of two adjacent but histologically distinct tumours with no histologic admixture at the interface.
The exact pathogenesis is not well known. They are most commonly composed of ovarian teratoma...
Colovaginal fistula is one form of genitourinary fistula. It is also sometimes classed under a type of gastro-intestinal fistula.
It refers to a communication between the colon (practically the rectum or sigmoid colon) with the vagina.
At times, specific terms are used dependent on ...
Corpus luteal (CL) cysts are a type of functional ovarian cyst that results when a corpus luteum fails to regress following the release of an ovum. When associated with pregnancy, it is the most common pelvic mass encountered within the 1st trimester. There is also some overlap with the term "ha...
Cystic endometrial hyperplasia is the most common as well as the most benign form of endometrial hyperplasia.
Typically shows endometrial thickening with associated cysts.
For imaging appearences consider:
prolonged proliferative phas...
Diffuse/disseminated peritoneal leiomyomatosis (DPL), also known as leiomyomatosis peritonealis disseminata, is an exceedingly rare benign disorder characterised by multiple vascular leiomyomas growing along the submesothelial tissues of the abdominopelvic peritoneum.
DPL is usual...
Ectopic pregnancy refers to the implantation of a fertilised ovum outside of the uterine cavity.
The overall incidence has increased over the last few decades and is currently thought to affect 1-2% of pregnancies. The risk is as high as 18% for first trimester pregnancies with bl...
Endometrial atrophy is a response to a hypo-oestrogenic state. If it occurs after menopause it can be more specifically termed postmenopausal endometrial atrophy.
While most patients are asymptomatic, endometrial atrophy is one of the commonest cause of postmenopausal bl...
Endometrial carcinoma is generally considered the most common gynaecological malignancy 1,5. It frequently presents with vaginal bleeding and both ultrasound and pelvic MRI are useful modalities for evaluation.
Incidence peaks at around the 6th decade, though 12% of cases present ...
Endometrial hyperplasia refers to an increased proliferation of the endometrial glands relative to the stroma. One of the main concerns is the potential malignant transformation of the endometrial hyperplasia to the endometrial carcinoma.
Endometrial hyperplasia affects women of a...
Endometrial stromal tumours (EST) are an uncommon group of tumours arising from endometrial stromal cells. It accounts for <2% of all uterine malignancies and 10% of all uterine sarcomas.
Half occur in premenopausal women, with most patients presenting in the 5th decade.
Endometrial thickness is a commonly measured parameter on routine gynaecological ultrasound and MR imaging. The appearance, as well as the thickness of the endometrium, will depend on whether the patient is of reproductive age or post-menopausal and, if of reproductive age, at what point in the ...
Endometrioid carcinoma of the endometrium is the most common histological subtype of endometrial carcinoma accounts for 85-90% of cases. It is considered a type I carcinoma of the uterus with slow progression and relatively good prognosis. Patients are usually 55 to 65 years old.
Endometrioid carcinomas of the ovary are a sub-type of epithelial ovarian tumours. The vast majority are malignant and invasive. On imaging, they are usually characterised as complex nonspecific solid-cystic masses and found associated with endometriosis.
Endometrioid carcinomas ...
Endometriomas, also known as chocolate cysts or endometriotic cysts, are a localised form of endometriosis and are usually within the ovary. They are readily diagnosed on ultrasound, with most demonstrating classical radiographic features.
These occur women of reproductive age.
Endometriosis affecting the canal of Nuck is an extremely rare site for endometriosis. It is proposed that retrograde implantation of endometrial tissue into patent canal of Nuck could give rise to the condition.
The condition is presented as a painful inguinal swelling. ...
Endometritis refers to inflammation or infection involving the endometrium. Endometritis can be acute or chronic and may arise in an obstetric setting, such as following delivery or miscarriage, or in a nonobstetric setting due to pelvic inflammatory disease (PID) or endometrial instrumentation....
Fanconi anaemia (FA) is a rare disorder characterised by progressive bone marrow failure, various congenital abnormalities, and predisposition to malignancies (often acute myeloid leukaemia). It is considered the commonest type of inherited marrow failure syndrome 7.
Gartner duct cysts develop from embryologic remnants of the Wolffian (mesonephric) duct. They are often noticed incidentally on ultrasound or MRI.
They may cause mass effect on adjacent structures.
Gartner duct cysts are located in the anterolateral ...
The term germinoma usually refers to a tumour of the brain (WHO Classification of CNS tumours), but can also refer to similar tumours of the ovary and testis.
dysgerminoma of the ovary
seminoma of the testis
All three tumours share similar histology.
Gestational choriocarcinoma (GC) is a type of choriocarcinoma that follows a gestational event. Similar to choriocarcinomas in general, it lies at the malignant end of the spectrum of gestational trophoblastic disease.
Approximately 50% of gestational choriocarcinomas arise from a pr...
Haemorrhagic ovarian cysts (HOCs) usually result from haemorrhage into a corpus luteum or other functional cyst. Radiographic features are variable depending on the age of the haemorrhage. They typically resolve within eight weeks.
Patients may present with sudden-onset ...
Hemimegalencephaly is a rare congenital disorder of cortical formation with hamartomatous overgrowth all or a part of a cerebral hemisphere. This results from either increased proliferation or decreased apoptosis (or both) of developing neurons 2.
Hemimegalencephaly is a cryptogen...
Hereditary breast and ovarian cancer (HBOC) syndrome is caused by mutation to either BRCA1 or BRCA2 genes. These patients have an increased risk of breast cancer, ovarian cancer, pancreatic cancer and prostate cancer. However, these gene mutations are not the only cause of hereditary breast canc...
Human epididymis protein 4 (HE4) is an emerging serum biomarker in the assessment of epithelial ovarian tumours. HE4 is a member of the whey associated protein (WAP) gene cluster and has uncertain biological function 1.
Early results indicate that HE4 has higher sensitivity and sensitivity than...
Hydatidiform moles are one of the most common but benign forms of gestational trophoblastic disease.
It is a common complication of gestation, estimated to occur in one of every 1,000-2,000 pregnancies 3. These moles can occur in a pregnant woman of any age, but the rate of occur...
Immature ovarian teratomas are uncommon ovarian germ cell tumours. They differ from mature ovarian teratomas (dermoid cysts) both histologically by the presence of immature tissue, and clinically by their more malignant behaviour.
They are considerably less common than mature ovar...
An incarcerated uterus or trapped uterus describes an extremely rare situation where a retroverted or retroflexed gravid uterus fails to ascend into the abdominal cavity.
This is an uncommon presentation and is said to occur in 1 in 3000 pregnancies. Uncomplicated retroversion may...
Interstitial ectopic pregnancy (also known as an intramural) is an important type of ectopic pregnancy with higher risks of rupture and haemorrhage compared to usual tubal ectopic pregnancies.
The term interstitial pregnancy is sometimes interchangeably used with cornual pregnancy...
Krukenberg tumour, also known as carcinoma mucocellulare, refers to the "signet ring" subtype of metastatic tumour to the ovary. The colon and stomach are the most common primary tumours to result in ovarian metastases, followed by the breast, lung, and contralateral ovary.
Leiomyomas of the uterine cervix are an unusual variation in terms of location for a uterine leiomyoma.
They are rare and account for ~5% (range 0.6-10%) of uterine leiomyomas 1,4.
Clinical symptoms of cervical leiomyomas, including hypermenorrhea, dysmenor...
A longitudinal vaginal septum is a congenital abnormality of the vagina where a septum divides it into two parallel cavities.
Usually asymptomatic unless obstructed and if obstructed it may cause cyclic pelvic pain. Amenorrhoea may occur if both cavities are obstructed 1....
Low-lying placenta occurs when the placenta extends into the lower uterine segment and its edge lies too close to the internal os of the cervix, without covering it. The term is usually applied when the placental edge is within 0.5-5.0 cm of the internal cervical os 1. Some alternatively give th...
Lymphoma of the uterine cervix is generally uncommon and when it does occur tends to present as cervical involvement with added background multi-organ disease rather than isolated primary cervical lymphoma 1. It is often considered part of the spectrum of uterine lymphoma.
In the ...
A malignant mixed germ cell tumour of the ovary is a subtype of ovarian germ cell tumour. These are not to be confused with malignant mixed Müllerian tumours of the ovary.
These tumours are rare. They most commonly affect adolescent women of reproductive age 1.
Menouria (Youssef syndrome) is an uncommon condition in which a vesico-uterine fistula results in cyclic haematuria. Vesicouterine fistulas are the rarest of all urinary fistulas, accounting for just 4% of all such fistulas 3. It occurs most commonly after cesarean section.
Metastases to the vagina are more common than primary vaginal malignancies, and account for >80% of vaginal tumors.
Metastases usually spread from contiguous sites most commonly, with lymphatic and hematogenous metastases also recognised.
Tumors that metastasise to the vagina includ...
Mixed gonadal dysgenesis (MGD) is a type of gonadal dysgenesis characterised by gonadal asymmetry, and/or sex chromosomal mosaicism, as well as retained Müllerian ducts.
Depending on the chromosomal composition, patients may have testes and/or streak gonads.
Mullerianosis is a rare type of choristoma, in which normal Mullerian-derived structures (endometrium, endosalpinx, and endocervix) are ectopically located in another organ (e.g. the bladder) through a developmental anomaly. Mullerianosis differs from endometriosis in that at least two types of ...
An omphalomesenteric duct cyst is a type of true umbilical cord cyst.
The omphalomesenteric duct serves as a communication between the midgut and yolk sac In early embryonic life and usually obliterates between the 9-18th week of gestation. The omphalomesenteric duct cyst is an embry...
Ovarian ectopic pregnancies are rare (1-3%) when compared to other types of ectopic pregnancy such as tubal ectopic.
Risk factors include pelvic inflammatory disease, IUCD use and endometriosis. Pathogenesis is debated and lies between:
fertilisation of the ovum in th...
Ovarian fibromas are a benign ovarian tumour of sex cord / stromal origin. Although fibromas account for ~4% of all ovarian neoplasms, they are the most common sex cord ovarian tumour.
Fibromas occur at all ages but are most frequently seen in middle-aged women.
Ovarian fibrosarcoma is a malignant mesenchymal fibroblastic tumour of the ovary that have multiple mitotic figures which is most important factor in histopathological diagnosis (4 or more mitotic figure per 10 high power fields).
Ovarian fibrosarcoma are very rare malignant ovar...
Ovarian hyperthecosis (OHT) is a condition where there is a presence of luteinized thecal cells within a hyperplastic ovarian stroma.
Clinical manifestations include hyperandrogenism, obesity, hypertension, and impaired glucose tolerance. Virilization has been reported to...
Ovarian lymphoma can refer to
primary involvement of the ovaries with lymphoma (i.e. primary ovarian lymphoma): very rare
secondary ovarian involvement of the ovaries with generalised lymphoma (i.e. secondary ovarian lymphoma): more common scenario
Ovarian serous cystadenocarcinoma is an ovarian epithelial tumour at the malignant end of the spectrum of ovarian serous tumours.
They account for the largest proportion of malignant ovarian tumours 1, representing over 50-80% of all malignant epithelial ovarian tumours 4. The pre...
Ovarian serous neoplasms are the commonest subtypes of the epithelial ovarian tumours, being more prevalent than the mucinous ovarian tumours. They are subdivided according to their malignant potential and clinical behaviour into:
benign serous cystadenoma / serous cystadenofibroma
Ovarian thecomas are benign ovarian tumours of sex cord / stromal (mesenchymal) origin. They are thought to account for approximately 0.5-1% of all ovarian tumours. As ovarian thecomas secrete oestrogen, they are described as functional ovarian tumours.
They typically present in o...
Ovarian torsion, also sometimes termed adnexal torsion or tubo-ovarian torsion, refers to rotation of the ovary and portion of the fallopian tube on the supplying vascular pedicle.
It can be intermittent or sustained and results in venous, arterial and lymphatic stasis. It is a gynaecological ...
Ovarian tumours are relatively common and account for ~6% of female malignancies. This article focuses on the general classification of ovarian tumours. For specific features, refer to the sub-articles.
Primary ovarian tumours
Surface epithelial stromal ovarian tumours (60...
Ovarian yolk sac tumours, also known as endodermal sinus tumours, are a type of ovarian germ cell tumours.
Ovarian yolk sac tumour is a rare malignant ovarian germ cell tumour that usually occurs around the second decade of life. It is considered the most common malignant germ cel...
P16 is a widely used immunohistochemical marker. It can be expressed in other neoplasms and in several normal human tissues. It can play an important role gynecological malignancy and is a surrogate marker for HSIL's (high-grade squamous intraepithelial lesions). It has been applied to facilitat...
Partial hydatidiform mole (PHD) is a sub type of a hydatidiform mole which in turn falls under the spectrum of gestational trophoblastic disease.
Clinical signs and symptoms such as abdominal pain, cramps of the lower abdomen and vaginal bleeding during pregnancy are non...
Parturition-induced pelvic instability is a rare condition seen in women following vaginal delivery.
The incidence of symphyseal rupture after vaginal delivery ranges from one in 600 to one in 30,000 deliveries 1.
Predisposing factors include multiparity, complicated delivery, ...
Pelvic inflammatory disease (PID) is a broad term that encompasses a spectrum of infection and inflammation of the upper female genital tract, resulting in a range of abnormalities.
The highest incidence is seen among sexually active women in their teens, with 75% cases being und...
Peritoneal inclusion cyst (PIC) (also known as a peritoneal pseudocyst) is a type of cyst-like structure that appears in relation to the peritoneum and results from a non neoplastic reactive mesothelial proliferation.
Peritoneal inclusion cysts occur almost exclusively in premenop...
A persistent right umbilical vein (PRUV) is an uncommon vascular anomaly which is often detected in utero.
The estimated prevalence is at ~2 per 1000 births 1-2.
In the normal situation, the right umbilical vein begins to obliterate in the ~4th week of gestation and di...
A placental septal cyst is a placental cyst typically located in a mid placenta. It forms between the cotyledons of the placenta. The cysts contain gelatinous material and are usually 5-10 mm in diameter. They may be present in 10-20% of placentas from full term uncomplicated pregnancies.
Placental site trophoblastic tumour (PSTT) is a rare and one of the least common (~ 0.2% 7) forms of gestational trophoblastic disease (GTD).
PSTT typically occurs in women of reproductive age with the average age around 30. It may occur after a normal pregnancy, molar pregnancy o...
Polycystic ovaries (PCO) is an imaging descriptor of a particular type of change in ovarian morphology. A proportion of women with polycystic ovaries will have the polycystic ovarian syndrome (PCOS), which in turn requires additional clinical as well as biochemical criteria. Otherwise PCO can be...
Posterior urethral valves (PUVs), also referred as congenital obstructing posterior urethral membranes (COPUM), are the most common congenital obstructive lesion of the urethra and a common cause of obstructive uropathy in infancy.
Posterior urethral valves are congenital and only...
The Potter sequence is a constellation of findings demonstrated postnatally as a consequence of severe, prolonged oligohydramnios in utero.
It consists of
pulmonary hypoplasia: often severe and incompatible with life
growth restriction (IUGR)
abnormal facies (Potter fa...
Preterm premature rupture of membranes (PPROM) refers to rupture of membranes prior to 37 weeks of gestation.
It is thought to occur in 0.4-2% of all pregnancies. It however may account for up to one-third of all preterm births (particularly in the United States 5).
Primary ovarian lymphoma (POL) refers to involvement of the ovary with lymphoma but without involvement of any other site. It is an extremely rare yet well recognised condition.
POL accounts for ~1.5% of ovarian tumours 5.
The rarity of this condition is probably contr...
Pulmonary hypoplasia (PH) refers to deficient or incomplete development of parts of the lung. It can develop as a result of a number of other in-utero anomalies.
The true prevalence is not well known (1.4% of all births according to Knox et.al 13), but in cases of premature ruptur...
Pyosalpinx refers to a Fallopian tube that is filled, and often distended, with pus.
A pyosalpinx often tends to be a complication of background pelvic inflammatory disease (PID). Inflammation results in tubal and peritubal adhesions with superimposed obstruction of the fimbrial end....
Retained products of conception (RPOC) refer to the persistence of placental and/or fetal tissue in the uterus following delivery, termination of pregnancy or a miscarriage.
Retained products of conception complicate ~1-5% of all pregnancies (routine vaginal deliveries 12).
Ruptured ovarian cysts are one of the most common causes of acute pelvic pain in premenopausal women. The sonographic appearance depends on whether a simple or hemorrhagic ovarian cyst ruptures, and whether the cyst has completely collapsed. The most important differential consideration is a rup...
Salpingitis isthmica nodosa (SIN), sometimes also referred to as perisalpingitis isthmica nodosa - PIN, refers to nodular scarring of the fallopian tubes. In very early stages, the tubes may appear almost normal. As scarring and nodularity progress, the changes become more radiographically appar...
Sclerosing stromal tumour (SST) of the ovary is a rare ovarian neoplasm. It is considered a subtype of ovarian sex cord / stromal tumour and is included in the fibroma-thecoma group of ovarian tumors 9.
It occurs predominantly in young women, peaks around 2nd to 3rd decades of lif...
Secondary involvement of the ovary with lymphoma is more common than primary ovarian lymphoma. It usually occurs a late manifestation of an advanced systemic disease, and are almost always of the non-Hodgkin type.
Squamous cell carcinoma (SCC) of the cervix is the most common histological subtype of cervical cancer and accounts for 80-90% of cases.
Most cervical squamous cell carcinomas grow at the squamocolumnar junction (SCJ). In younger women, the SCJ is located outside the external uterine...
Struma ovarii tumour is a subtype of an ovarian teratoma and is composed entirely or predominantly of thyroid tissue and containing variable-sized follicles with colloid material.
It accounts for 0.3-1% of all ovarian tumours and ~3% of all mature cystic teratomas 1.
Teratomas are germ cell tumours that arise from ectopic pluripotent stem cells that fail to migrate from yolk sac endoderm to the urogenital ridge during embryogenesis. By definition, they contain elements from all three embryological layers: endoderm, mesoderm and ectoderm although frequently, ...
Theca lutein cysts (TLC), also known as hyperreactio luteinalis (HL), are a type of functional ovarian cysts. They are typically multiple and seen bilaterally.
They are thought to originate due to excessive amounts of circulating gonadotrophins such as beta-hCG. Hyperplasia of the th...
Thoracic endometriosis is an uncommon location for endometriosis and the main cause of catamenial pneumothorax.
Most often occurs in the third and fourth decades of life 3.
Symptoms may include:
catamenial pleuritic chest pain
catamenial haemoptysis: whe...
Triploidy is a rare lethal chromosomal (aneupliodic) abnormality caused by the presence of an entire extra chromosomal set.
It is considered the 3rd commonest fatal chromosomal anomaly 7. While it is thought to affect as much as 1-2% of conceptions, the vast majority are thought ...
Tuberculosis of the fallopian tube is one of the most common sites of tuberculous pelvic inflammatory disease.
Many patients may be asymptomatic, with the disease being discovered during the workup for infertility. Signs and symptoms are often vague and can include acut...
Tuberculous pelvic inflammatory disease refers to pelvic inflammatory disease due to Mycobacterium tuberculosis.
Genital tract involvement may be present in ~1.5% of cases of those affected with tuberculosis 4.
Infection almost always results from spread from an extrag...
Tubo-ovarian abscesses (TOA) are one of the late complications of pelvic inflammatory disease (PID).
Patients typically present with fever, elevated white blood cell count, lower abdominal-pelvic pain, and/or vaginal discharge. Fever and leukocytosis may sometimes be abse...
Tunnel cluster (TC) is a type of Nabothian cyst characterised by complex multicystic dilatation of the endocervical glands.
Tunnel cluster is found in ~8% of adult women, 40% of whom are pregnant, almost exclusively multigravid women, and older than 30 years.
Uterine artery pseudoaneurysm (UAP) is a rare cause of secondary postpartum haemorrhage.
UAP usually presents as delayed (secondary) postpartum haemorrhage, that is per vaginal bleeding which occurs more than 24 hours and up to 6 weeks postpartum. However, some reported ...
Uterine leiomyomas, also referred as uterine fibroids, are benign tumours of myometrial origin and are the most common solid benign uterine neoplasms. Commonly an incidental finding on imaging, they rarely cause a diagnostic dilemma. There are various medical, surgical and interventional treatme...
Uterine leiomyosarcomas are malignant uterine tumours that arises from the myometrium. The uterus is the commonest location for a leiomyosarcoma.
Typically present in women in the 6th decade. They account for up to one-third of uterine sarcomas but only ~8% of all uterine cancers ...
Uterine lymphoma refers to involvement of the uterus with lymphoma. Some authors also place lymphoma of the uterine cervix under this group.
It is rare condition with initial uterine involvement occurring in only 1% of patients with lymphoma 3. However, uterine involvement is more...
Uterine rupture is a rare but nevertheless potentially catastrophic complication that can occur in pregnancy.
The incidence rate in pregnancy is at 0.05% 6.
Uterine rupture is usually an acute presentation with haemodynamic instability and abdominal disc...