Articles

Articles are a collaborative effort to provide a single canonical page on all topics relevant to the practice of radiology. As such, articles are written and edited by countless contributing members over a period of time. A global group of dedicated editors oversee accuracy, consulting with expert advisers, and constantly reviewing additions.

43 results found
Article

CA-125

Serum CA-125 is well recognised as an ovarian cancer-associated marker and is an antigen determinant on a high-molecular-weight glycoprotein. The normal range of CA-125 is 0-35 U/mL. Serum CA-125 levels can also be used to monitor the response to treatment as well as a prognostic indicator sinc...
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CA 19-9 elevation

CA 19-9 (carbohydrate antigen 19-9 or cancer antigen) is a serum antigen (monosialoganglioside) that has increased diagnostic use in the management of several malignancies, mainly of hepatopancreaticobiliary origin. It is non-specific, however, and can rise in both malignant and non-malignant co...
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Carcinoembryonic antigen

Serum carcinoembryonic antigen (CEA) is a cell-adhesive glycoprotein that was discovered in colorectal cancer in 1965, and is hence one of the oldest and most used tumour markers. Its name derives from its normal expression in fetoembryonic liver, gut and pancreas tissue. Normal range of CEA is...
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Hepatoblastoma histological classification

Although hepatoblastomas can be histologically classified into a variety of sub types, it is important to remember that with the possible exception of small cell undifferentiated sub type, prognosis is independent of histology when adjusted for stage gender and age 1. major categories epitheli...
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Infantile hepatic haemangioma

Infantile hepatic haemangiomas (IHH) are a liver lesion composed of large endothelial-lined vascular channels seen in fetuses and neonates. It should not be confused with a hepatic epithelioid haemangioendothelioma, which occurs in older patients. Terminology Those benign tumours were previous...
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Inferior vena cava web

Inferior vena cava (IVC) webs are an uncommon condition characterised by obstruction of the hepatic segment of the inferior vena cava by a membrane or fibrous band. This is often associated with occlusion of one or more of the hepatic veins. Clinical presentation If there is hepatic vein invol...
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Inflammatory hepatic adenoma

Inflammatory hepatic adenomas are a genetic and pathological subtype of hepatic adenoma. Their appearance and prognosis is different than other subtypes and has highest incidence of haemorrhage amongst hepatic adenoma subtypes. Epidemiology Most common subtype of hepatic adenoma (40-50%). Occu...
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Inflammatory myofibroblastic tumour

Inflammatory myofibroblastic tumours (IMT), also known as plasma cell granulomas, are rare neoplasms that have a diverse spectrum of biological behaviour.  Epidemiology It can occur at any age and there is currently no recognised gender predilection. Pathology Composed of spindle cells (key ...
Article

Insulinoma

Insulinomas are the most common sporadic endocrine tumour of the pancreas. Epidemiology Account for 40% of syndromic pancreatic endocrine tumours. Overall incidence of ~0.0003%. Clinical presentation Typically insulinomas present with Whipple's triad consisting of: fasting hypoglycemia (<50...
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Interstitial oedematous pancreatitis

Interstitial oedematous pancreatitis is one of the two subtypes of acute pancreatitis. It is normally referred to as "acute pancreatitis" or "uncomplicated pancreatitis" in day-to-day use. Please refer to the article on acute pancreatitis for further details. 
Article

Intraductal papillary mucinous neoplasm

Intraductal papillary mucinous neoplasms or tumours (IPMNs or IMPTs) are cystic tumours of the pancreas. Epidemiology These tumours are most frequently identified in older patients (50-60 years of age) 6, and thus is sometimes colloquially referred to as the "grandfather lesion". Main duct typ...
Article

Jaundice

Jaundice refers to a clinical sign of hyperbilirubinemia (>2.5 mg/dl) which has many causes. It is often a clue to a diagnosis. It can be largely divided into two types: non-obstructive, i.e. pre-hepatic and hepatic causes obstructive, i.e. post-hepatic causes Imaging has a major role in dete...
Article

Limy bile

Limy bile stands for the presence of a viscous substance in the dependent parts of the gallbladder and/or bile ducts, almost entirely composed of calcium carbonate, and therefore highly radiopaque. Terminology The terms limy bile and calcium milk gallbladder can be used interchangeably for inc...
Article

Liquefactive necrosis

Liquefactive necrosis is a form of necrosis where there is transformation of the tissue into a liquid viscous mass. Pathology In liquefactive necrosis, the affected cell is completely digested by hydrolytic enzymes leading to a soft, circumscribed lesion which can consist of fluid with remains...
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Mastocytosis

Mastocytosis is a disorder of excessive mast cell proliferation, which is now classified as a myeloproliferative neoplasm. Two clinical entities fall under the mastocytosis umbrella: cutaneous (urticaria pigmentosa) and systemic mastocytosis (with or without cutaneous manifestations). The articl...
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Myelofibrosis

Myelofibrosis is a haematological disorder where there is the replacement of bone marrow with collagenous connective tissue and progressive fibrosis. It is also classified as a myeloproliferative disorder. It is characterised by: extramedullary hematopoiesis (EMH) progressive splenomegaly ana...
Article

Nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) occurs when fat is deposited into hepatocytes without a known cause (such as with alcoholic fatty liver disease). The deposition of fat may lead to hepatic inflammation (hepatitis) and may eventually lead to cirrhosis. Terminology "Nonalcoholic fatty li...
Article

Pancreatic intraepithelial neoplasia

Pancreatic intraepithelial neoplasia (PanIN) is a precursor lesion to pancreatic ductal adenocarcinoma, but the frequency at which this transition occurs is unknown.  Epidemiology Increasing incidence with age 1. Risk factors: obesity pancreatic lipomatosis 3 Pathology More commonly locat...
Article

Pancreatic lipomatosis

Pancreatic lipomatosis refers to fatty replacement of pancreatic parenchyma. This finding is most often associated with obesity and aging.  It tends to be commonest pathological condition involving the pancreas. The condition may occassionally simulate a mass like lesion particularly when fatty...
Article

Pancreatic lymphoma

Pancreatic lymphoma is most commonly a B-cell sub-type of non-Hodgkin lymphoma and is classified as either primary or secondary: primary pancreatic lymphoma is a rare extranodal manifestation of any histopathologic subtype of B-cell non-Hodgkin's lymphoma, representing < 2% of extranodal lympho...
Article

Pancreatic pseudocyst

Pancreatic pseudocysts are common sequelae of acute pancreatitis or chronic pancreatitis, and the most common cystic lesion of the pancreas. They are important both in terms of management and differentiation from other cystic processes or masses in this region. Terminology The following are th...
Article

Pancreatic trauma

The pancreas is uncommonly injured in blunt trauma. However, pancreatic trauma has a high morbidity and mortality. Imaging features range between subtle to obvious. Epidemiology The pancreas is injured in ~7.5% (range 2-13%) of blunt trauma cases 1,3. Motor vehicle accidents account for the va...
Article

Pancreatoblastoma

Pancreatoblastomas are rare paediatric tumours of the pancreas. However, they are the most common pancreatic neoplasm of childhood and are often associated with a raised alpha-fetoprotein. Epidemiology There is slight male predilection. Usually occurs in the first decade of life with a mean ag...
Article

Paraduodenal pancreatitis

Paraduodenal pancreatitis is an uncommon type of focal chronic pancreatitis affecting the groove between the head of the pancreas, the duodenum and the common bile duct. Terminology The following entities with which it shares clinicopathological features are unified by this term and should no ...
Article

Passive hepatic congestion

Passive hepatic congestion or congested liver in cardiac disease is the stasis of blood in the hepatic parenchyma, due to impaired hepatic venous drainage which leads to widening and splaying of the central hepatic veins and hepatomegaly.  Passive hepatic congestion is a well-studied result of ...
Article

Portopulmonary hypertension

Portopulmonary hypertension (POPH/PPHTN) refers to pulmonary artery hypertension that develops in the setting of portal hypertension (with or without underlying liver disease). It falls under group 1.4 under the Dana point 2008 pulmonary hypertension classification system. Epidemiology The pre...
Article

Posttransplant lymphoproliferative disorder (PTLD)

Post-transplant lymphoproliferative disorder (PTLD), also referred as post-transplant lymphoproliferation disorder, represents a variety of conditions ranging from lymphoid hyperplasia to malignancy, included in the 2008 WHO classification of tumours of haematopoietic and lymphoid tissues. It ca...
Article

Primary biliary cholangitis

Primary biliary cholangitis (PBC) is a chronic progressive cholestatic liver disease that is the cause of 1-2% of deaths from cirrhosis and constitutes the third most common indication for liver transplantation in adults. Terminology The name of this disease was changed from primary biliary ci...
Article

Primary hepatic lymphoma

Primary hepatic lymphoma (PHL) is rare accounting for roughly 100 described cases. If it is being considered as a diagnosis, distal lymphadenopathy, splenomegaly, bone marrow disease, and leukaemia should not be present for at least 6 months after the liver tumour is detected (see: secondary hep...
Article

Primary hyperoxaluria

Primary hyperoxaluria, also referred as primary oxalosis, is a congenital autosomal recessive disease related to a liver enzyme deficiency leading to massive cortical nephrocalcinosis and renal failure.  Please, refer on secondary oxalosis for a discussion on the acquired form of hyperoxaluria....
Article

Rhabdomyosarcomas (biliary tract)

Rhabdomyosarcomas of the biliary tract are rare tumours, usually identified in children, with a very poor prognosis. They are usually grouped under botryoid rhabdomyosarcomas. For a general discussion of this type of tumour, please refer to the article on rhabdomyosarcomas. Epidemiology Rhabd...
Article

Sarcoidosis (abdominal manifestations)

Sarcoidosis is a systemic inflammatory disease of unknown origin characterized by the formation of non-caseating granulomas. Virtually any organ system may be involved.  Although the involvement of abdominal viscera is less frequent than pulmonary and mediastinal disease when it occurs, it may m...
Article

Schistosomiasis

Schistosomiasis (also referred to as bilharzia or snail fever) is the result of infection by blood fluke (trematode worm) of the Schistosoma species. Epidemiology Schistosomiasis is very common, affecting over 200 million people, with the vast majority (85%) in Africa. It is prevalent in tropi...
Article

Schistosomiasis (hepatic manifestations)

Schistosomiasis hepatic manifestations are a chronic result of the deposition of eggs into small portal venules leading to periportal fibrosis and liver cirrhosis.   For a general view over this trematode infection, please refer to the main article on schistosomiasis.  Clinical presentation U...
Article

Scleroderma

Scleroderma, also known as systemic sclerosis, is an autoimmune connective tissue disorder characterised by multisystem fibrosis and soft tissue calcification. As such, it affects many separate organ systems, which are discussed separately: musculoskeletal manifestations of scleroderma pulmona...
Article

Secondary hepatic involvement with lymphoma

Secondary hepatic involvement with lymphoma (secondary hepatic lymphoma) is common, much more so than primary hepatic lymphoma.  Clinical presentation Hepatomegaly with deranged liver function tests is the most common presentation. Jaundice is common. Rarely, patients may present with acute li...
Article

Serous cystadenoma of pancreas

Serous cystadenoma of the pancreas (or microcystic adenoma) is an uncommon type of benign cystic pancreatic neoplasm.  Epidemiology There is a recognised strong female predilection (M:F ~ 1:4) and usually presents in middle age to elderly patients (>60 years of age).  Clinical presentation M...
Article

Sickle cell disease

Sickle cell disease (SCD) is a hereditary (autosomal recessive) condition resulting in the formation of abnormal haemoglobin (a haemoglobinopathy), which manifests as multisystem ischaemia and infarction, as well as haemolytic anaemia.  Epidemiology There is no recognised gender predilection. ...
Article

Simple hepatic cyst

Simple hepatic cysts are common benign liver lesions and have no malignant potential. They can be diagnosed on ultrasound, CT, or MRI. Epidemiology Simple hepatic cysts are one of the commonest liver lesions, occurring in ~2-7% of the population 1-2. There may be a slight female predilection. ...
Article

Spindle cell hepatocellular carcinoma

Spindle cell hepatocellular carcinoma, also called sarcomatoid hepatocellular carcinoma, is a rare variant of hepatocellular carcinoma (HCC). These patients are reported to have low or normal AFP levels, otherwise risk factors and clinical presentation are similar to typical hepatocellular carci...
Article

Splenic hamartoma

Splenic hamartomas are very rare and usually solitary although may be present as multiple nodules present in tuberous sclerosis or Wiskott-Aldrich syndrome. The only recently described entity sclerosing angiomatoid nodular transformation (SANT) of the spleen, a non-neoplastic vascular entity de...
Article

Splenic hydatid infection

Splenic hydatid infection is a rare form of Hydatid disease, and isolated splenic involvement is even less common. Epidemiology Splenic hydatid disease has been reported to constitute up to 4% of cases of abdominal hydatid disease 4. Pathology Splenic hydatid cysts are usually solitary. As t...
Article

Splenic infarction

Splenic infarction is a result of ischaemia to the spleen, and in many cases requires no treatment. However, identification of the cause of infarction is essential.   Epidemiology Splenic infarcts can occur due to a number processes, involving either arterial supply, the spleen itself and the ...

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