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11 results found

2005 WHO histological classification of odontogenic tumours

The 2005 WHO histological classification of odontogenic tumours lays out a classification system for neoplasms and other tumours related to the odontogenic apparatus. At the time of writing (2016), it is still the most widely used classification system although a new revision is due to come up i...


Serum CA-125 is well recognised as an ovarian cancer-associated marker and is an antigen determinant on a high-molecular-weight glycoprotein. The normal range of CA-125 is 0-35 U/mL. Serum CA-125 levels can also be used to monitor the response to treatment as well as a prognostic indicator sinc...

CA 19-9 elevation

CA 19-9 (carbohydrate antigen 19-9 or cancer antigen) is a serum antigen (monosialoganglioside) that has increased diagnostic use in the management of several malignancies, mainly of hepatopancreaticobiliary origin. It is non-specific, however, and can rise in both malignant and non-malignant co...

Carcinoembryonic antigen

Serum carcinoembryonic antigen (CEA) is a cell-adhesive glycoprotein that was discovered in colorectal cancer in 1965, and is hence one of the oldest and most used tumour markers. Its name derives from its normal expression in fetoembryonic liver, gut and pancreas tissue. Normal range of CEA is...

Circumferential resection margin

The circumferential resection margin (CRM) is a term used in rectal carcinoma excision surgery (such as total mesorectal excision (TME)). Pathologic evaluation of the resection margin on the excised rectum has been considered important for determining the risk of local recurrence. A margin of ≤...


Eosinophils (or less commonly acidophiles) are myeloid granulocytes and form one of the main types of white blood cells. Their counts are routinely measured as part of a full blood count. They have important roles in fighting parasitic infections, but it is increasingly recognised that they have...

Myoinositol peak

Myoinositol is one of the compounds images with MR spectroscopy (MRS) at both 1.5 T and 3 T and is seen to resonate at 3.5 ppm chemical shift (right of the choline peak).  Myoinositol is a precursor of both phosphatidylinositol (the major inositol-containing phospholipid) and of phosphatidylino...

Prostate specific antigen

Prostate specific antigen (PSA) is currently used as a tumour marker for prostate adenocarcinoma. PSA is a 33 kilodalton glycoprotein produced in prostate epithelial cells. Its normal physiologic role is as a liquefying agent for seminal fluid; only a tiny amount leaks into the blood, therefore...

Prostate-specific membrane antigen

Prostate-specific membrane antigen (PSMA) (also known as glutamate carboxypeptidase II) is a type II transmembrane glycoprotein that has become an increasingly prominent imaging biomarker 1. PSMA has emerged as a useful target in PET imaging of prostate cancer, especially in the evaluation of sm...

Tumour markers

Tumour markers are a group of molecules in serum that are elevated in various malignancies and are often used to monitor treatment response as well as alert for potential progressive disease when in remission. Commonly used markers include: AFP beta-hCG CA 19-9 CA-125 CEA chromogranin A P...

WHO histological classification of tumours of the uterine cervix

The WHO histological classification is a detailed classification of tumours of the uterine cervix. epithelial tumours squamous tumours and precursors squamous cell carcinoma, not otherwise specified - 8070/3 keratinizing - 8071/3 non-keratinizing - 8072/3 basaloid - 8083/3 verrucous - 805...

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