Articles are a collaborative effort to provide a single canonical page on all topics relevant to the practice of radiology. As such, articles are written and edited by countless contributing members over a period of time. A global group of dedicated editors oversee accuracy, consulting with expert advisers, and constantly reviewing additions.

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Atypical small acinar proliferation

Atypical small acinar proliferations (ASAP) are premalignant lesions of the prostate, which can be found in as many as 5% of prostate biopsies. They are suspicious glands without adequate histologic atypia to establish a definitive diagnosis of prostate cancer. Some studies showed that there is ...


A cyst is an abnormal fluid-filled structure which is lined by epithelium; with one exception: lung cysts contain gas, not fluid. By contradistinction, a pseudocyst lacks an epithelial lining and instead has a vascular and fibrotic capsule. Cysts are extremely common and found in most organs. E...


Diverticula are outpouchings of a hollow viscus and can be either true or false. Diverticulum is the singular form and diverticula is the correct Latin plural form. 'Diverticuli' and 'diverticulae' are erroneous and should not be used (cf. septum).  True diverticula contains all layers of the...

Prostate specific antigen

Prostate specific antigen (PSA) is currently used as a tumour marker for prostate adenocarcinoma. PSA is a 33 kilodalton glycoprotein produced in prostate epithelial cells. Its normal physiologic role is as a liquefying agent for seminal fluid; only a tiny amount leaks into the blood, therefore...

Prostate-specific membrane antigen

Prostate-specific membrane antigen (PSMA) (also known as glutamate carboxypeptidase II) is a type II transmembrane glycoprotein that has become an increasingly prominent imaging biomarker 1. PSMA has emerged as a useful target in PET imaging of prostate cancer, especially in the evaluation of sm...

Schiller-Duval body (histology)

Schiller-Duval body is a perivascular structure that can be found in 50% of testicular yolk sac tumours also known as endodermal sinus tumours. If present it is considered pathognomonic.  Pathology A central vessel is surrounded by tumour cells, and the cell-vessel complex is contained in a cy...


Urine represents the biofluid end-product of the renal filtration process. Normally it is a transparent, sterile, pale-yellow liquid (although clearly colour varies with the person's hydration status).  Urine is one of the most easily-accessible biofluids in the human body and has been intensiv...

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