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Atypical small acinar proliferation

Atypical small acinar proliferations (ASAP) are premalignant lesions of the prostate, which can be found in as many as 5% of prostate biopsies. They are suspicious glands without adequate histologic atypia to establish a definitive diagnosis of prostate cancer. Some studies showed that there is ...

Prostate specific antigen

Prostate specific antigen (PSA) is currently used as a tumour marker for prostate adenocarcinoma. PSA is a 33 kilodalton glycoprotein produced in prostate epithelial cells. Its normal physiologic role is as a liquefying agent for seminal fluid; only a tiny amount leaks into the blood, therefore...

Prostate-specific membrane antigen

Prostate-specific membrane antigen (PSMA) (also known as glutamate carboxypeptidase II) is a type II transmembrane glycoprotein that has become an increasingly prominent imaging biomarker 1. PSMA has emerged as a useful target in PET imaging of prostate cancer, especially in the evaluation of sm...

Schiller-Duval body (histology)

Schiller-Duval body is a perivascular structure that can be found in 50% of testicular yolk sac tumours also known as endodermal sinus tumours. If present it is considered pathognomonic.  Pathology A central vessel is surrounded by tumour cells, and the cell-vessel complex is contained in a cy...


Urine represents the biofluid end-product of the renal filtration process. Normally it is a transparent, sterile, pale-yellow liquid (although clearly colour varies with the person's hydration status).  Urine is one of the most easily-accessible biofluids in the human body and has been intensiv...

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