White matter volu...
Axial T2 and T1
White matter volume is severely decreased. There is minimal myelination of the posterior or anterior limbs of the internal capsule, periventricular white matter, or optic radiations (which is normally expected to be myelinated by this age)
Modality: MRI (T2 and T1)

- “ Pelizaeus-Merzbacher disease is an X-linked leukodystrophy (PLP1 gene at chromosome Xq22), which presents with severe white matter volume loss and...”

Used in the following article:

  • Pelizaeus-Merzbacher disease - “ Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy which is characterized by an arrest in myelin development.  Clinical presentatio...”

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