The diagnosis of Creutzfeldt-Jakob disease (CJD) has been established, with further corroborating clinical features and CSF. Initially, the cognitive decline started with depressive features, sleep disturbance then myoclonic jerks and ataxia. CSF was positive for 14-3-3 protein. Imaging features are also characteristic. 

A differential to always consider is autoimmune encephalitis, particularly anti-D2 dopamine antibodies, which can have a similar distribution of imaging changes and similar initial presentation. Helpful in distinguishing between the two is that T2 signal change is dominant in autoimmune encephalitis, whereas diffusion change is most striking in CJD.