What is the likely diagnosis? What is the differential diagnosis of acro-osteolysis
The most likely diagnosis is Scleroderma. Causes of acro-osteolysis: Mneumonic: PINCH FO Psoriasis Pyknodysostosis Injury (thermal burn, frostbite) Neuropathy - Diabetes - Leprosy Collagen vascular disease - Scleroderma - Raynaud's disease Hyperparathyroidism Familial (Hadju-Cheney syndrome) Other - Polyvinyl chloride exposure - Progeria
This series shows severe contractures, dislocations, acro-osteolysis. Loss of muscle bulk and loss of skin folds. No soft tissue calcification