Histiocytosis X is most often seen in children ages 1 to 15 with the peak incidence at 1-4
years of age.
The rate peaks among children ages 5 to10 years. It most commonly affects skull among the flat bones and femur among the long bones. The diagnostic tests that can be carried out in children are:
- Skin biopsy for the presence of Langerhans cells
- Bone marrow biopsy for the presence of Langerhans cells
- Complete blood count
- X-rays skeletal survey to find out number of affected bones.