Histology
MICROSCOPIC DESCRIPTION: The core biopsies show features of a poorly differentiated non-small cell carcinoma with areas of necrosis. The tumour forms sheets and cords, surrounded by inflamed stroma. The tumour cells have enlarged pleomorphic nuclei, prominent nucleoli and small amounts of ill-defined pale eosinophilic cytoplasm. There is no evidence of keratinisation. No glandular structures are seen. No evidence of lymphovascular invasion is identified. The tumour cells are p63, CK5/6 and CK7 positive, indicating squamous differentiation. They are TTF-1, synaptophysin and melan-A negative.
DIAGNOSIS: Left superior sulcus: Poorly differentiated squamous cell carcinoma.